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Autolog hematopoietisk stamcelletransplantasjon ved multippel sklerose
(Master thesis; Mastergradsoppgave, 2017-09-18)Autolog hematopoietisk stamcelletransplantasjon (HSCT) er eit nytt behandlingsalternativ for pasientar med attakkprega multippel sklerose (MS) i Norge som har betydeleg sjukdomsaktivitet til tross for tilgjengeleg immunmodulerande behandling etter gjeldande retningslinjer. Det er i dag få pasientar som oppfyller dei norske kriteria og per desember 2016 har kun 22 pasientar fått behandling i Norge, ... -
Autologous chondrocyte implantation for hip osteochondritis functioning 15 years after operation
(Journal article; Tidsskriftartikkel, 2016-11-30)<b>Background:</b> The autologous implantation technique (ACI) was first introduced in studies on cartilage defects in knees. It has later been used for the treatment of osteochondral knee lesions. The patient presented here had a hip osteochondral defect measuring 4 cm in diameter. He was a candidate for hip prosthesis because of serious pain and reduced function. Being young and highly motivated ... -
Automated analysis of color tissue Doppler velocity recordings of the fetal myocardium using a new algorithm
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-27)Background: Tissue Doppler imaging (TDI) can be used to assess fetal cardiac function and it has been shown to detect changes associated with hypoxia in animal models. However, the analysis is cumbersome and time consuming. The main objective of this study was to evaluate the feasibility of a new algorithm developed for the automated analysis of color TDI velocity recordings of the fetal myocardium. ... -
Automated analysis of fetal cardiac function using color tissue Doppler imaging in second half of normal pregnancy
(Journal article; Tidsskriftartikkel, 2018-02-26)<i>Objectives</i> - Color tissue Doppler imaging (cTDI) is a promising tool for the assessment of fetal cardiac function. However, the analysis of myocardial velocity traces is cumbersome and time‐consuming, limiting its application in clinical practice. The aim of this study was to evaluate fetal cardiac function during the second half of pregnancy and to develop reference ranges using an ... -
Automated calibration for stability selection in penalised regression and graphical models
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-13)Stability selection represents an attractive approach to identify sparse sets of features jointly associated with an outcome in high-dimensional contexts. We introduce an automated calibration procedure via maximisation of an in-house stability score and accommodating a priori-known block structure (e.g. multi-OMIC) data. It applies to [Least Absolute Shrinkage Selection Operator (LASSO)] penalised ... -
Automated quantitative evaluation of fetal atrioventricular annular plane systolic excursion
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-07)Objectives The primary aim of this study was to evaluate the feasibility of automated measurement of fetal atrioventricular (AV) plane displacement (AVPD) over several cardiac cycles using myocardial velocity traces obtained by color tissue Doppler imaging (cTDI). The secondary objectives were to establish reference ranges for AVPD during the second half of normal pregnancy, to assess fetal ... -
Automated segmentation of magnetic resonance bone marrow signal: a feasibility study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-02)Background - Manual assessment of bone marrow signal is time-consuming and requires meticulous standardisation to secure adequate precision of findings.<p> <p>Objective - We examined the feasibility of using deep learning for automated segmentation of bone marrow signal in children and adolescents.<p> <p>Materials and methods - We selected knee images from 95 whole-body MRI examinations of ... -
Automatic measurements of left ventricular volumes and ejection fraction by artificial intelligence reduces time-consumption and inter-observer variability
(Conference object; Konferansebidrag, 2023-06-19) -
Automatic measurements of left ventricular volumes and ejection fraction by artificial intelligence: clinical validation in real time and large databases
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-26)Aims - Echocardiography is a cornerstone in cardiac imaging, and left ventricular (LV) ejection fraction (EF) is a key parameter for patient management. Recent advances in artificial intelligence (AI) have enabled fully automatic measurements of LV volumes and EF both during scanning and in stored recordings. The aim of this study was to evaluate the impact of implementing AI measurements on acquisition ... -
Autonomi blant sykehjemsbeboere
(Master thesis; Mastergradsoppgave, 2014-05-07)Forskning om livskvalitet på sykehjem viser at det er viktig for beboere å bestemme i hverdagen i saker som angår dem selv. På sykehjem virker det mer naturlig å snakke om medbestemmelse isteden for selvbestemmelse. Studiens hensikt har vært å belyse fem sykepleieres opplevelser og erfaringer knyttet til beboeres autonomi på sykehjem.For å finne svar på problemstillingen ble fem sykepleiere som ... -
Autonomi og meningsdannelse i klinisk resonnering - En kvalitativ intervjustudie om fysioterapeuters erfaringer med å anvende fysioterapitilnærmingen ICoreDIST når det kommer til klinisk resonnering og valg i fysioterapi
(Mastergradsoppgave; Master thesis, 2022-05-04)Sammendrag Hensikt og bakgrunn: Denne studien har til hensikt å tilføre fagfeltet ny kunnskap gjennom ny innsikt i fysioterapeuters opplevelse av å bruke fysioterapitilnærmingen ICoreDIST for personer med hjerneslag i subakutt fase når det kommer til klinisk resonnering og valg i fysioterapi. Bakgrunnen for valgt tema og problemstilling er pasientgruppens store utbredelse og manglende forskning ... -
Autonomous or controlled self-regulation, that is the question: A self-determination perspective on the impact of commuting on employees’ domain-specific functioning
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-01)The few studies that have considered psychological processes during the commute have drawn an ambiguous picture, with some emphasizing the negative and others the positive consequences of commuting. Drawing on self-determination theory, we develop a framework that expands on the costs and benefits of commuting for employees’ subsequent domain-related functioning at work and home. Specifically, we ... -
Autophagy : investigating the possible interaction between cochaperone BAG3 and the Ubiquitin-binding protein p62
(Master thesis; Mastergradsoppgave, 2010-09-15)Introduction: Autophagy is an evolutionary conserved intracellular catabolic process which involves the degradation of a cell’s own components. The degradation happens in two (2)main pathways: the ubiquitin-proteasome system that degrades short-lived proteins, and the autophagy system that degrades long-lived proteins and damaged organelles. There are three known different pathways of autophagy ... -
Autophagy and endocytosis – interconnections and interdependencies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-22)Autophagy and endocytosis are membrane-vesicle-based cellular pathways for degradation and recycling of intracellular and extracellular components, respectively. These pathways have a common endpoint at the lysosome, where their cargo is degraded. In addition, the two pathways intersect at different stages during vesicle formation, fusion and trafficking, and share parts of the molecular machinery. ... -
Autophagy in major human diseases
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-30)Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction ... -
Autoregulation of Cerebral Blood Flow During 3-h Continuous Cardiopulmonary Resuscitation at 27°C
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-09)Introduction: Victims of accidental hypothermia in hypothermic cardiac arrest (HCA) may survive with favorable neurologic outcome if early and continuous prehospital cardiopulmonary resuscitation (CPR) is started and continued during evacuation and transport. The efficacy of cerebral autoregulation during hypothermic CPR is largely unknown and is aim of the present experiment.<p> <p>Methods: ... -
Autotransplantasjon av visdomstenner. Litteraturgjennomgang og retrospektiv undersøkelse.
(Master thesis; Mastergradsoppgave, 2014)Bakgrunn: Denne masteroppgaven fokuserer på autotransplantasjon av visdomstenner med lukket apex hos voksne pasienter, og hvorvidt dette er et godt behandlingsalternativ for erstatning av hovedsakelig tapt første eller andre molar. Mål: Presentere autotransplantasjon som behandling i en allmenntannleges praksis, med fokus på den voksne pasient og bruk av modne visdomstenner som ... -
Availability and Affordability of Medicines for the Treatment of Cardiovascular Diseases in Pharmacies in Six Regions of the Russian Federation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018)<i>Aim</i>: To evaluate the availability and affordability of medicines used to treat of cardiovascular diseases (CVD) in several regions of the Russian Federation with different climatic, geographic, economic and demographic characteristics.<p> <p><i>Material and methods</i>: The study was conducted in 6 regional capitals, chosen to differ in geographically, economically, and demographically. ... -
AvaLife—A New Multi-Disciplinary Approach Supported by Accident and Field Test Data to Optimize Survival Chances in Rescue and First Aid of Avalanche Patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-26)Snow sports in the backcountry have seen a steep increase in popularity, and therefore preparedness for efficient companion and organized rescue is important. While technical rescue skills are widely taught, there is a lack of knowledge regarding first aid for avalanche patients. The stressful and time-critical situation for first responders requires a rule-based decision support tool. AvaLife ... -
Avatars using computer/smartphone mediated communication and social networking in prevention of sexually transmitted diseases
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Sexually transmitted diseases (STDs), especially the Chlamydia trachomatis bacterial infection, a common cause of infertility, are highly prevalent in developed countries, and a worrying problem in North Norway, where the incidence of chlamydia twice the Norwegian average. Seventy percent of reported chlamydia cases are found in people below 25 years of age, and although its spread could be controlled ...
