Objective. To study the relative importance of different tools a GP can use during the diagnostic process towards cancer detection. <p>Design. Retrospective cohort study with prospective registration of cancer in general practice. Setting and subjects. One hundred and fi fty-seven Norwegian general practitioners (GPs) reported 261 cancer patients.<p> Method. During 10 consecutive days, GPs ...

Bakgrunn: Synkope er definert som et forbigående tap av bevissthet, som følge av global cerebral hypoperfusjon, og karakterisert av rask start, kort varighet og spontan full tilfriskning. Synkope er et symptom som pasienten presenterer, men er ikke i seg selv en diagnose. Formålet med denne oppgaven er å kartlegge de vanligste årsakene til synkope som utskrivelsesdiagnose, hvilken utredning, behandling ...

The adenosine A_2A receptor (A_2AR) has emerged as a potential non-dopaminergic target for the treatment of Parkinson’s disease and, thus, the non-invasive imaging with positron emission tomography (PET) is of utmost importance to monitor the receptor expression and occupancy during an A_2AR-tailored therapy. Aiming at the development of a PET radiotracer, we herein ...

Effective antimicrobial drugs are the very core of modern medicine enabling successful prevention and treatment of infectious diseases. However, systemic misuse and overuse of antibiotics in human medicine, as well as in animal husbandry have led to widespread antibiotic-resistance, rendering many of these drugs ineffective. Therefore, there is an urgent need for new treatment options to conventional ...

Nanoparticles are usually defined as particles in a size range of 1-100 nm, and these particles often have different properties than the non-nanoscale material of the same chemical composition. In recent years, as the interest and use of nanoparticles has increased and so has the interest in understanding their behaviour, impact and fate in the environment. In the last decades, there has been special ...

The synthesis, cytotoxicity, inhibition of tubulin polymerization and anti-angiogenic effects of 10 analogs of 2-methoxyestradiol are reported. These efforts revealed that the analog with a 4-pyridine ring in the 17-position, in combination with 2-ethyl- and 3-sulfamate substituents on the steroid A-ring, is the most interesting anti-cancer agent. This compound showed potent inhibitory effects against ...

Enzymes of the M4 family of zinc-metalloproteinases are virulence factors secreted from gram-positive or gram-negative bacteria, and putative drug targets in the treatment of bacterial infections. In order to have a therapeutic value such inhibitors should not interfere with endogenous zinc-metalloproteinases. In the present study we have synthesised a series of hydroxamate derivatives and validated ...

The global spread of antimicrobial resistance and the increasing number of immune‐compromised patients are major challenges in modern medicine. Targeting bacterial virulence or the human host immune system to increase host defence are important strategies in the search for novel antimicrobial drugs. We investigated the inflammatory response of the synthetic short antimicrobial peptide LTX21 in two ...

The primary aim of this study is to summarise research findings about the use of assessment frameworks, that is, structured models that guide information collection and decision making in child protection services, by reviewing the literature. The research review method consisted of identification, selection, coding, categorisation and summary of publications on child protection investigative work. ...

We investigated whether a novel visitation model for school-aged youth with mental health problems based on a stage-based stepped-care approach facilitated a systematic identification and stratification process without problems with equity in access. The visitation model was developed within the context of evaluating a new transdiagnostic early treatment for youth with anxiety, depressive symptoms, ...