-aminobutyric acid (GABA) is the chief inhibitory neurotransmitter of the central nervous system (CNS). GABA exhibits its function by binding to either the ionotropic GABAA receptor or the metabotropic GABAB receptor, causing a decrease in activity in the nervous system. Disruption in the GABAergic system has been associated with various neurological conditions, including Alzheimer’s disease, anxiety, ...

Body composition after kidney transplantation is linked to glucose metabolism, and impaired glucose metabolism is associated with increased risk of cardiovascular events and death. One year after transplantation we examined 150 patients for new-onset diabetes performing OGTTs and body composition measurements including visceral adipose tissue (VAT) content from dual-energy X-ray absorptiometry ...

<i>Aim</i> - The aim was to compare adult patients’ experiences of public and private dental care in Sweden over time from the ages of 50 and 70 years, between 1992 and 2012.<p><p> <i>Materials and methods</i> - Data on visiting patterns, oral health, fees and satisfaction were obtained from a questionnaire study every 5 years in 1992–2012 and analysed by using the Chi-square test and logistic ...

School nursing involves relationships and understandings based on young people’s needs. Visual technologies have become a central part of young people’s life and context: they use their phones to communicate and shape their relationships and they turn to social media when inquiring about health issues. Visual methods in health communication thus draw on existing practices, and are well documented ...

This experimental study compared the direct technique indocyanine green fluorescence angiography (ICG-FA) and the indirect technique dynamic infrared thermography (DIRT) for visualising skin perfusion. Eight isolated human transverse abdominal skin flaps, obtained from female patients undergoing abdominoplasty, were used. A total of 19 selected vessels were individually perfused. Warm and cold ...

Background and aim: Vitamin A have been shown to influence immunity, and animal studies have shown that maternal vitamin A intake could have immunomodulatory effects that may influence offspring type 1 diabetes (T1D) development. There are few human studies that have investigated the association between vitamin A consumption and T1D. This study aimed to examine the association between maternal vitamin ...

The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. DHCR7(rs12785878), CYP2R1 rs12794714) and their combined synthesis score were chosen to proxy 25(OH)D. ...

Background:<br>Vitamin D deficiency may be a risk factor for mortality but previous meta-analyses lacked standardization of laboratory methods for 25-hydroxyvitamin D (25[OH]D) concentrations and used aggregate data instead of individual participant data (IPD). We therefore performed an IPD meta-analysis on the association between standardized serum 25(OH)D and mortality.<br>Methods:<br>In a European ...

Background:<br>Vitamin D deficiency has been described as being pandemic, but serum 25-hydroxyvitamin D [25(OH)D] distribution data for the European Union are of very variable quality. The NIH-led international Vitamin D Standardization Program (VDSP) has developed protocols for standardizing existing 25(OH)D values from national health/nutrition surveys.<br>Objective:<br>This study applied VDSP ...