Classifying breast cancer molecular subtypes is crucial for tailoring treatment strategies. While immunohistochemistry (IHC) and gene expression profiling are standard methods for molecular subtyping, IHC can be subjective, and gene profiling is costly and not widely accessible in many regions. Previous approaches have highlighted the potential application of deep learning models on hematoxylin ...

Bakgrunn - Trombolysebehandling tidligst mulig etter symptomstart påvirker behandlingsresultatet ved akutt hjerneinfarkt. Målet med studien var å kartlegge om avstanden fra sykehus påvirker trombolysetilbudet ved akutt hjerneinfarkt ved Universitetssykehuset Nord-Norge Tromsø.<p> <p>Materiale og metode - I denne prospektive kvalitetsstudien inkluderte vi 231 pasienter innlagt med akutt hjerneinfarkt ...

School teachers are a professional group that are responsible for a large proportion of reports concerning suspected child abuse and neglect. This study looks at which concerns are more often reported by schools and if these reports are more likely substantiated when the school is the reporter. The study was designed as a retrospective case-file study (N = 883). Results show that concerns about the ...

The SAMINOR Study represents a unique data collection on health and diseases among the multiethnic population – including the Sámi population in Norway – making it a case study for discussing Sámi research data governance in a health context. This article describes how Sámi interests and needs in the SAMINOR Study are governed by two steps of a research application review process consisting of the ...

Pro-inflammatory cytokines, like interleukin-1 beta and interferon gamma, are known to activate signalling pathways causing pancreatic beta cell death and dysfunction, contributing to the onset of diabetes. Targeting cytokine signalling pathways offers a potential strategy to slow or even halt disease progression, reducing reliance on exogenous insulin and improving glucose regulation. This ...

Beskrivelse: Kinder Lebensqualität Fragebogen (KINDL®) er et spørreskjema som måler livskvalitet hos barn og unge (3–17 år). Spørreskjemaet ble utviklet i Tyskland, sist revidert i 1998 av Ravens-Sieberer og Bullinger, og oversatt til norsk i 2004 av Thomas Jozefiak og Sølvi Helseth. KINDL® inneholder selv-rapporteringsskjema for barn og foresatte med ulike alderstilpassede versjoner. Det er ingen ...

Objectives There is limited evidence regarding the impact of lipid-lowering drugs (LLDs) on the socioeconomic gradient in a longitudinal perspective. The study investigates the longitudinal socioeconomic gradient in total cholesterol levels and whether this is affected by the use of LLDs.<p> <p>Design Population-based cohort study. <p>Setting Sample from adult inhabitants of Tromsø municipality, ...

Background With improvements in cancer treatment and early detection, the number of people living with cancer is increasing.<p> <p>Objective This study aimed to investigate the association between combined prediagnostic lifestyle factors, assessed by a Healthy Lifestyle Index (HLI) score, and mortality among women diagnosed with breast cancer (BC), colorectal cancer (CRC) and lung cancer ...

Bakgrunn og formål: Eksponering for vibrasjoner fra håndholdte vibrerende verktøy kan gi negative helseeffekter i form av hånd-/armvibrasjonssyndrom (HAVS). HAVS kan være en arbeidsrelatert tilstand med stort forebyggingspotensial. Bedriftshelsetjenesten har et særskilt fortrinn når det gjelder å bidra til å forebygge arbeidsrelaterte tilstander. Oppgavens formål var å utforske hvordan helsepersonell ...

Background Identifying spontaneous circulation during cardiopulmonary resuscitation (CPR) is challenging. Current methods, which involve intermittent and time-consuming pulse checks, necessitate pauses in chest compressions. This issue is problematic in both in-hospital cardiac arrest and out-of-hospital cardiac arrest situations, where resources for identifying circulation during CPR may be limited. ...