Viser treff 241-260 av 11024

    • Massive entry of BK Polyomavirus induces transient cytoplasmic vacuolization of human renal proximal tubule epithelial cells 

      Lorentzen, Elias Myrvoll; Henriksen, Stian; Rinaldo, Christine Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-21)
      BK polyomavirus (BKPyV) is a ubiquitous human virus that establishes a persistent infection in renal tubular epithelial cells and mainly causes disease in kidney transplant recipients. The closely related simian polyomavirus SV40 is known to cause cytoplasmic vacuolization in simian kidney cells, possibly increasing progeny release and cell death. This study aimed to determine whether BKPyV causes ...
    • Care Convoys and Solitary Vessels: Navigating Family Care for Older Adults Living With Dementia in Arctic Norway 

      Blix, Bodil Hansen; Ågotnes, Gudmund (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-09)
      Drawing on the metaphor of “care convoys,” this study explores the experiences and strategies of family caregivers of older adults with dementia in rural areas of Northern Norway. The study is part of a broader project that investigates how these older adults and their caregivers use or do not use municipal health and care services. We conducted qualitative in-depth interviews with 11 family caregivers ...
    • Impact of B7-H3 expression on metastasis, immune exhaustion and JAK/STAT and PI3K/AKT pathways in clear cell renal cell carcinoma 

      Emaldi, Maite; Rey-Iborra, Esther; Marín, Ángela; Mosteiro, Lorena; Lecumberri, David; Øyjord, Tove Ragnhild; Roncier, Noémie; Mælandsmo, Gunhild Mari; Angulo, Javier C.; Errarte, Peio; Larrinaga, Gorka; Pulido, Rafael; López, José I.; Nunes-Xavier, Caroline Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-01)
      Immune checkpoint inhibitors in combination with tyrosine kinase inhibitors (TKIs) are improving the response rates of advanced renal cancer patients. However, many treated patients do not respond, making novel immune checkpoint-based immunotherapies potentially clinically beneficial only for specific groups of patients. We detected high expression of the immune checkpoint protein B7-H3 in clear ...
    • Challenges and Strategies in Nursing Leadership: A Qualitative Study on Leaders in Mental Health Care 

      Lysfjord, Else Marie; Gjevjon, Edith Lillian Roth; Skarstein, Siv (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-10)
      Aim: To explore the challenges and strategies among new and experienced nursing leaders in mental healthcare; furthermore, to identify factors that support or hinder their leadership roles. Background: Strong nursing leadership is crucial for the quality of patient care and is associated with higher job security and better patient outcomes. Understanding what factors contribute to effective leadership ...
    • Work-leave rotation among general practitioners in Norwegian municipalities 

      Prestgaard, Erik Edvard; Fosse, Anette; Abelsen, Birgit; Harbitz, Martin Bruusgaard (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-19)
      Bakgrunn - Flere kommuner har innført rotasjonsordning (nordsjøturnus) for allmennleger, der legene gjennom året veksler mellom arbeidsperioder og friperioder. Vi har undersøkt utbredelsen av, årsaker til, innhold i og erfaringer med denne arbeidsformen.<p> <p>Materiale og metode - Vi har gjennomført en flerkasusstudie med data fra Statistisk sentralbyrå, fastlegeregisteret, kommunale dokumenter, ...
    • Comparison between the EKFC-equation and machine learning models to predict Glomerular Filtration Rate 

      Nakano, Felipe Kenji; Åkesson, Anna; de Boer, Jasper; Dedja, Klest; D’hondt, Robbe; Haredasht, Fateme Nateghi; Björk, Jonas; Courbebaisse, Marie; Couzi, Lionel; Ebert, Natalie; Eriksen, Bjørn Odvar; Dalton, R. Neil; Derain-Dubourg, Laurence; Gaillard, Francois; Garrouste, Cyril; Grubb, Anders; Jacquemont, Lola; Hansson, Magnus; Kamar, Nassim; Legendre, Christophe; Littmann, Karin; Mariat, Christophe; Melsom, Toralf; Rostaing, Lionel; Rule, Andrew D.; Schaeffner, Elke; Sundin, Per-Ola; Bökenkamp, Arend; Berg, Ulla; Åsling-Monemi, Kajsa; Selistre, Luciano; Larsson, Anders; Nyman, Ulf; Lanot, Antoine; Pottel, Hans; Delanaye, Pierre; Vens, Celine (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-02)
      In clinical practice, the glomerular filtration rate (GFR), a measurement of kidney functioning, is normally calculated using equations, such as the European Kidney Function Consortium (EKFC) equation. Despite being the most general equation, EKFC, just like previously proposed approaches, can still struggle to achieve satisfactory performance, limiting its clinical applicability. As a possible ...
    • Validity of self-reported number of pregnancies and maternal age at first birth among females attending organized mammographic screening 

      Tsuruda, Kaitlyn; Langseth, Hilde; Ursin, Giske; Hofvind, Solveig Sand-Hanssen; Turzanski Fortner, Shannon Renee (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-22)
      Aims: Reproductive history conveys information about potential health risks later in adulthood. This study aimed to examine the validity of self-reported number of pregnancies and maternal age at first birth (AFB) among females attending BreastScreen Norway.<p> <p>Methods: Participants were identified through the Janus Serum Bank cohort in Norway and were eligible for this cross-sectional validation ...
    • Breathing signatures of semantic and phonemic verbal fluency and their impact on test performance in a sample of young Norwegian adults 

      Gullsvåg, Malin; Itaguchi, Yoshihiro; Rodriguez Aranda, Claudia Ericka (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-05)
      Verbal fluency (VF) represents an important aspect of intelligence, in which oral word generation is demanded following semantic or phonemic cues. Two reliable phenomena of VF execution have been reported: A decay in performance across 1-minute trial and a discrepancy score between the semantic and phonemic VF tests (VFTs). Although, these characteristics have been explained from various cognitive ...
    • Assessing primary information sources and knowledge of menstruration among adolescent girls in Nepal: A cross-sectional study 

      Shrestha, Sudip (Master thesis; Mastergradsoppgave, 2023-12-01)
      <p>Background: Adolescent girls, aged 10-19, undergo a critical physiological transition during which menarche and monthly menstrual cycles signify normal physiological functioning. In Nepal, cultural myths and taboos stigmatize menstruation, contributing to misconceptions that lead to self-isolation, social exclusion, and negative impacts on physical and mental health. The study aims to assess ...
    • Impact of competition on profit and revenue of pharmacies in Norway 

      Karn, Rupesh (Master thesis; Mastergradsoppgave, 2023-12-01)
      <p>Introduction: Since 2001, due to the change in the Pharmacy Act, the accessibility of pharmacies to the public has considerably increased due to the increase in the number of pharmacies owned by chain wholesalers. In terms of pharmaceutical brands, competition serves as a driving force that compels brands to make new, effective, and enhanced medicines while encouraging generic companies to provide ...
    • Review article: A scoping review of human factors in avalanche decision-making 

      Hetland, Audun; Hetland, Rebecca Anne; Skille, Tarjei Tveito; Mannberg, Hanna Andrea (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-26)
      The interest in understanding the human aspects of avalanche risk mitigation has steadily grown over the past few decades. Between 2001–2011, 11 research papers on decision-making in avalanche terrain were published in peer-reviewed journals. Between 2012–2022, this number rose to 55. These papers have been authored by researchers from various disciplines and publications in journals across different ...
    • Prevalence of obesity and its associations with other cardiovascular risk factors in Russia. Insights from the Know Your Heart Study 

      Kholmatova, Kamila (Doctoral thesis; Doktorgradsavhandling, 2024-12-16)
      <p><i>Background.</i> The prevalence of obesity has reached epidemic proportions worldwide. Obesity is a risk factor for the development of cardiovascular disease (CVD) and predisposes to hypertension, type 2 diabetes mellitus (T2D) and dyslipidemia. The simultaneous presence of visceral adiposity and these cardiometabolic disorders, also known as the metabolic syndrome, accelerates atherosclerotic ...
    • Plasma phosphorylated-tau217 is increased in Niemann–Pick disease type C 

      Gonzalez-Ortiz, Fernando; Karikari, Thomas K.; Vruchte, Danielle Taylor-Te; Shepherd, Dawn; Kirsebom, Bjørn-Eivind Seljelid; Fladby, Tormod; Platt, Frances; Blennow, Kaj (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-25)
      Niemann–Pick disease type C and Alzheimer’s disease are distinct neurodegenerative disorders that share the presence of neurofibrillary tangle pathology. In this multicentre study, we measured plasma phosphorylated-tau217 in controls (n = 60), Niemann–Pick disease type C (n = 71) and Alzheimer’s disease (n = 30 positive for amyloid and negative for tau in CSF [A+ T−] and n = 30 positive for both ...
    • Menopausal hormone therapy and incidence, mortality, and survival of breast cancer subtypes: a prospective cohort study 

      Busund, Marit Katinka; Ursin, Giske; Lund, Tore Eiliv; Chen, Sairah Lai Fa; Rylander, Karin Charlotta Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-04)
      Background Menopausal hormone therapy (MHT) is associated with an increased risk of postmenopausal breast cancer, predominantly the luminal A-like subtype. The impact of MHT on deaths from breast cancer subtypes is less understood. This study aimed to explore associations between MHT use and the incidence, mortality, and survival of intrinsic-like breast cancer subtypes.<p> <p>Methods Data from ...
    • Timely empirical antibiotic therapy against sepsis in a rural Norwegian ambulance service: a prospective cohort study 

      Andersson, Lars-Jøran; Simonsen, Gunnar Skov; Solligård, Erik; Fredriksen, Knut Endre (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-31)
      Background Early diagnosis and antibiotic therapy in patients with sepsis reduce morbidity and mortality, thus pre-hospital management is likely to affect patient outcomes. Pre-hospital administration may increase the risk of unnecessary use of broad-spectrum antibiotics, but identification of an infectious focus enables more targeted antibiotic therapy. The aim of this study was to investigate ...
    • The patient’s voice: a cross-sectional study of physical health and disability in juvenile idiopathic arthritis 

      Arneng, Sofie Mikalsen; Jenssen, Isabelle Pignatel; Lundestad, Anette; Cetrelli, Lena Elisabet; Angenete, Oskar W; Nordal, Ellen Berit; Tylleskär, Karin Birgitta; Romundstad, Pål Richard; Rygg, Marite (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-18)
      Background With increasing focus on patient-reported outcome measures (PROMs) in chronic rheumatic diseases, we aimed to evaluate the self-reported physical and psychosocial health in children with juvenile idiopathic arthritis (JIA) compared to matched population-based controls. Furthermore, we aimed to study the association of patient and physician-reported outcome measures in JIA with ...
    • PFAS exposure is associated with an unfavourable metabolic profile in infants six months of age 

      Monsen, Anne-Lise Bjørke; Holstad, Kristin; Huber, Sandra; Averina, Maria; Bolann, Bjørn; Brox, Jan (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-01)
      Exposure to perfluoroalkyl substances (PFAS) are reported to have numerous negative health effects and children are especially vulnerable. The aim of this study was to investigate whether maternal and infant PFAS burden have any impact on prenatal and postnatal growth, liver and lipid parameters in infants at age six months. Data on diet and growth parameters, as well as blood samples were collected ...
    • Exploring the unconventional: health professionals’ experiences into medication-free treatment for patients with severe mental illness 

      Reitan, Elisabeth Cecilie Klæbo; Riley, Henriette; Høifødt, Tordis Sørensen; Iversen, Valentina Maria Do Rosario Cab; Høye, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-14)
      Background In January 2017, the Norwegian government mandated the establishment of an inpatient unit for“medication-free treatment” for patients with severe mental illness at the University Hospital of North Norway in Tromsø. This study aims to explore the employees’ experiences with this unit.<p> <p>Method Focus group interviews were conducted October 2021 – February 2022. For analysis, the ...
    • COVID-19 morbidity, severity, and mortality in a population-based sample of adults in Arkhangelsk, Northwest Russia 

      Krieger, Ekaterina (Doctoral thesis; Doktorgradsavhandling, 2024-12-12)
      <p><i>Objective</i> To investigate seroprevalence, spectrum of COVID-19 cases and factors associated with COVID-19 morbidity, severity, and mortality in a population-based sample of adults in Arkhangelsk, Northwest Russia. <p><i>Methods</i> Participants in the Know Your Heart study (2015-2017) were enrolled in a COVID-19 seroprevalence study (n=1348) in 2021 and followed up for COVID-19 diagnosis, ...
    • Initial interpretation scores of screening mammograms and cancer detection in BreastScreen Norway 

      Hovda, Tone; Sagstad, Silje; Moshina, Nataliia; Vigeland, Einar; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-12)
      Purpose - To explore the association between radiologists’ interpretation scores, early performance measures and cumulative reading volume in mammographic screening.<p> <p>Method - We analyzed 1,689,731 screening examinations (3,379,462 breasts) from BreastScreen Norway 2012–2020, all breasts scored 1–5 by two independent radiologists. Score 1 was considered negative/benign and score ≥2 positive ...