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dc.contributor.authorAhlen, Maria Therese
dc.contributor.authorHusebekk, Anne
dc.contributor.authorKillie, Mette Kjær
dc.contributor.authorKjeldsen-Kragh, Jens
dc.contributor.authorOlsson, Martin L.
dc.contributor.authorSkogen, Bjørn Ragnar
dc.date.accessioned2012-09-10T12:25:10Z
dc.date.available2012-09-10T12:25:10Z
dc.date.issued2012
dc.description.abstractBackground. Maternal alloantibodies against HPA-1a can cross placenta, opsonize foetal platelets, and induce neonatal alloimmune thrombocytopenia (NAIT). In a study of 100, 448 pregnant women in Norway during 1995–2004, 10.6% of HPA-1a negative women had detectable anti-HPA-1a antibodies. Design and Methods. A possible correlation between the maternal ABO blood group phenotype, or underlying genotype, and severe thrombocytopenia in the newborn was investigated. Results. We observed that immunized women with blood group O had a lower risk of having a child with severe NAIT than women with group A; 20% with blood group O gave birth to children with severe NAIT, compared to 47% among the blood group A mothers (relative risk 0.43; 95% CI 0.25–0.75). Conclusion. The risk of severe neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies is correlated to maternal ABO types, and this study indicates that the observation is due to genetic properties on the maternal side.en
dc.identifier.citationClinical and Developmental Immunology (2012), Article ID 156867en
dc.identifier.issn1740-2522
dc.identifier.otherFRIDAID 918006
dc.identifier.otherdoi: 10.1155/2012/156867
dc.identifier.urihttp://hdl.handle.net/10037/4428
dc.identifier.urnURN:NBN:no-uit_munin_4142
dc.language.isoengen
dc.publisherHindawi Publishing Corporationen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gynecology and obstetrics: 756en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756en
dc.titleThe development of severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-1a Antibodies is correlated to maternal ABO genotypesen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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