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dc.contributor.authorKostenko, Sergiy Viktorovich
dc.contributor.authorDumitriu, Giania Aurica
dc.contributor.authorMoens, Ugo
dc.date.accessioned2012-09-10T12:55:50Z
dc.date.available2012-09-10T12:55:50Z
dc.date.issued2012
dc.description.abstractPerturbed action of signal transduction pathways, including the mitogen-activated protein (MAP) kinase pathways, is one of the hallmarks of many cancers. While the implication of the typical MAP kinase pathways ERK1/2-MEK1/2, p38MAPK and JNK is well established, recent findings illustrate that the atypical MAP kinase ERK3/4-MK5 may also be involved in tumorigenic processes. Remarkably, the ERK3/4-MK5 pathway seems to possess anti-oncogenic as well as pro-oncogenic properties in cell culture and aninal models. This review summarizes the mutations in the genes encoding ERK3, ERK4 and MK5 that have been detected in different cancers, reports aberrant expression levels of these proteins in human tumours, and discusses the mechanisms by which this pathway can induce senescence, stimulate angiogenesis and invasiveness.en
dc.identifier.citationJournal of Molecular Signaling (2012), vol. 7:9en
dc.identifier.cristinIDFRIDAID 935120
dc.identifier.doidoi: 10.1186/1750-2187-7-9
dc.identifier.issn1750-2187
dc.identifier.urihttps://hdl.handle.net/10037/4433
dc.identifier.urnURN:NBN:no-uit_munin_4144
dc.language.isoengen
dc.publisherBioMed Centralen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en
dc.titleTumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5.en
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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