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dc.contributor.authorSørbye, Sveinung Wergeland
dc.contributor.authorKilvær, Thomas Karsten
dc.contributor.authorValkov, Andrey Yurjevich
dc.contributor.authorDønnem, Tom
dc.contributor.authorSmeland, Eivind
dc.contributor.authorAl-Shibli, Khalid Ibrahim
dc.contributor.authorBremnes, Roy M.
dc.contributor.authorBusund, Lill-Tove
dc.date.accessioned2012-10-18T12:49:46Z
dc.date.available2012-10-18T12:49:46Z
dc.date.issued2012
dc.description.abstractBACKGROUND: Prognostic markers in curable STS may have the potential to guide therapy after surgical resection. The purpose of this study was to clarify the prognostic impact of the presence of cells and growth factors belonging to the innate immune system in soft tissue sarcomas (STS). The significance of macrophages (CD68), their growth factor macrophage colony-stimulating factor (M-CSF), its receptor colony-stimulating factor-1 receptor (CSF-1R), natural killer cells (CD57) and the general immunomodulating molecule (TGF-beta) are all controversial in STS. Herein, these markers are evaluated and compared to the cell proliferation marker Ki67. METHODS: Tissue microarrays from 249 patients with non-gastrointestinal (non-GIST) STS were constructed from duplicate cores of viable and representative neoplastic tumor areas and duplicate cores of peritumoral capsule. Immunohistochemistry was used to evaluate the expression of CD68, M-CSF, CSF-1R, CD57, TGF-beta and Ki67 in tumor and peritumoral capsule. RESULTS: In univariate analyses increased expression of M-CSF (P = 0.034), Ki67 (P < 0.001) and TGF-beta (P = 0.003) in tumor correlated with shorter disease-specific survival (DSS). Increased expression of CD68 in tumor correlated significantly with malignancy grade (P = 0.016), but not DSS (P = 0.270). Increased expression of Ki67 in peritumoral capsule tended to correlate with a shorter DSS (P = 0.057). In multivariate analyses, co-expression of M-CSF and TGF-beta (P = 0.022) in tumor and high expression of Ki67 (P = 0.019) in peritumoral capsule were independent negative prognostic factors for DSS. CONCLUSIONS: Increased co-expression of M-CSF and TGF-beta in tumor in patients with STS, and increased expression of Ki67 in peritumoral capsule were independent negative prognostic factors for DSS.en
dc.descriptionThis paper is part of Sveinung Sørbye's doctoral thesis, available in Munin at <a href=http://hdl.handle.net/10037/5478>http://hdl.handle.net/10037/5478</a>
dc.identifier.citationBMC Clinical Pathology 12(2012)en
dc.identifier.cristinIDFRIDAID 931867
dc.identifier.doidoi: 10.1186/1472-6890-12-7
dc.identifier.issn1472-6890
dc.identifier.urihttps://hdl.handle.net/10037/4562
dc.identifier.urnURN:NBN:no-uit_munin_4257
dc.language.isoengen
dc.publisherBioMed Centralen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::General surgery: 780en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Generell kirurgi: 780en
dc.titlePrognostic impact of CD57, CD68, M-CSF, CSF-1R, Ki67 and TGF-beta in soft tissue sarcomasen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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