• Amyloid plaques and symptoms of depression links to medical help-seeking due to subjective cognitive decline 

      Espenes, Ragna; Kirsebom, Bjørn-Eivind; Eriksson, Cecilia Magdalena; Waterloo, Knut K; Hessen, Erik; Johnsen, Stein Harald; Selnes, Per; Fladby, Tormod (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-02)
      <i>Background:</i> Subjective cognitive decline (SCD) is associated with an increased risk of Alzheimer’s disease (AD). However, patients reporting SCD to their general practitioner are not always referred to a memory clinic.<p> <p><i>Objective:</i> To investigate whether prior history of medical help-seeking is associated with AD biomarker abnormality, worse cognitive performance, and/or depressive ...
    • Cerebrospinal fluid markers for synaptic function and Alzheimer type changes in late life depression 

      Siafarikas, Nikias Ioannis; Kirsebom, Bjørn-Eivind; Srivastava, Deepak P; Eriksson, Cecilia Magdalena; Auning, Eirik; Hessen, Erik; Selbæk, Geir; Blennow, Kaj; Aarsland, Dag; Fladby, Tormod (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-13)
      To explore markers for synaptic function and Alzheimer disease (AD) pathology in late life depression (LLD), predementia AD and normal controls (NC). A cross-sectional study to compare cerebrospinal fluid (CSF) levels of neurogranin (Ng), Beta-site amyloid-precursor-protein cleaving enzyme1 (BACE1), Ng/BACE1 ratio and Amyloid-β 42/40 ratio, phosphorylated-tau and total-tau in LLD with (LLD AD) or ...
    • In Brief Neuropsychological Assessment, Amnestic Mild Cognitive Impairment (MCI) Is associated with Cerebrospinal Fluid Biomarkers for Cognitive Decline in Contrast to the Prevailing NIA-AA MCI Criterion 

      Hessen, Erik; Kirsebom, Bjørn-Eivind; Eriksson, Cecilia Magdalena; Eliassen, Carl Fredrik Andestad; Nakling, Arne; Bråthen, Geir; Waterloo, Knut; Aarsland, Dag; Fladby, Tormod (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-22)
      <i>Background:</i> In the care of persons with cognitive problems, it is important to use a valid mild cognitive impairment (MCI) criterion that discriminates well between normal and pathological aging.<p> <p><i>Objective:</i> To find the brief neuropsychological screening criterion that best correlates with cerebrospinal fluid (CSF) biomarkers for cognitive decline and dementia in persons ...