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dc.contributor.authorLenkin, A
dc.contributor.authorKirov, Mikhail
dc.contributor.authorKuzkov, Vsevolod
dc.contributor.authorParomov, KV
dc.contributor.authorSmetkin, Alexey Anatolievich
dc.contributor.authorLie, Mons
dc.contributor.authorBjertnæs, Lars J.
dc.date.accessioned2013-03-11T09:46:40Z
dc.date.available2013-03-11T09:46:40Z
dc.date.issued2012
dc.description.abstractOur aim was to compare the effects of goal-directed therapy guided either by pulmonary artery catheter (PAC) or by transpulmonary thermodilution (TTD) combined with monitoring of oxygen transport on perioperative hemodynamics and outcome after complex elective valve surgery. Measurements and Main Results. Forty patients were randomized into two equal groups: a PAC group and a TTD group. In the PAC group, therapy was guided by mean arterial pressure (MAP), cardiac index (CI) and pulmonary artery occlusion pressure (PAOP), whereas in the TTD group we additionally used global end-diastolic volume index (GEDVI), extravascular lung water index (EVLWI), and oxygen delivery index (DO2I). We observed a gradual increase in GEDVI, whereas EVLWI and PAOP decreased by 20–30% postoperatively (P < 0.05). The TTD group received 20% more fluid accompanied by increased stroke volume index and DO2I by 15–20% compared to the PAC group (P < 0.05). Duration of mechanical ventilation was increased by 5.2 hrs in the PAC group (P = 0.04). Conclusions. As compared to the PAC-guided algorithm, goal-directed therapy based on transpulmonary thermodilution and oxygen transport increases the volume of fluid therapy, improves hemodynamics and DO2I, and reduces the duration of respiratory support after complex valve surgery.en
dc.identifier.citationCritical Care Research and Practice (2012), Article ID 821218, 10 ppen
dc.identifier.cristinIDFRIDAID 972595
dc.identifier.doihttp://dx.doi.org/10.1155/2012/821218
dc.identifier.issn2090-1305
dc.identifier.urihttps://hdl.handle.net/10037/4939
dc.identifier.urnURN:NBN:no-uit_munin_4656
dc.language.isoengen
dc.publisherHindawi Publishing Corporationen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Vascular and thoracic surgery: 782en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kar- og thoraxkirurgi: 782en
dc.titleComparison of Goal-Directed Hemodynamic Optimization using Pulmonary Artery Catheter and Transpulmonary Thermodilution in Combined Valve Repair: A Randomized Clinical Trialen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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