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dc.contributor.authorBukowski, Radek
dc.contributor.authorChlebowski, Rowan
dc.contributor.authorThune, Inger
dc.contributor.authorFurberg, Anne-Sofie
dc.contributor.authorHankins, Gary
dc.contributor.authorMalone, Fergal
dc.contributor.authorD'Alton, Mary
dc.date.accessioned2013-03-13T15:06:59Z
dc.date.available2013-03-13T15:06:59Z
dc.date.issued2012
dc.description.abstractPrevious studies have shown that woman’s risk of breast cancer in later life is associated with her infants birth weights. The objective of this study was to determine if this association is independent of breast cancer risk factors, mother’s own birth weight and to evaluate association between infants birth weight and hormonal environment during pregnancy. Independent association would have implications for understanding the mechanism, but also for prediction and prevention of breast cancer. Risk of breast cancer in relation to a first infant’s birth weight, mother’s own birth weight and breast cancer risk factors were evaluated in a prospective cohort of 410 women in the Framingham Study. Serum concentrations of estriol (E3), anti-estrogen alpha-fetoprotein (AFP), and pregnancy-associated plasma protein-A (PAPP-A) were measured in 23,824 pregnant women from a separate prospective cohort, the FASTER trial. During follow-up (median, 14 years) 31 women (7.6 %) were diagnosed with breast cancer. Women with large birth weight infants (in the top quintile) had a higher breast cancer risk compared to other women (hazard ratio (HR), 2.5; 95% confidence interval (CI), 1.2–5.2; P = 0.012). The finding was not affected by adjustment for birth weight of the mother and traditional breast cancer risk factors (adjusted HR, 2.5; 95% CI, 1.2–5.6; P = 0.021). An infant’s birth weight had a strong positive relationship with the mother’s serum E3/AFP ratio and PAPP-A concentration during pregnancy. Adjustment for breast cancer risk factors did not have a material effect on these relationships. Giving birth to an infant with high birth weight was associated with increased breast cancer risk in later life, independently of mother’s own birth weight and breast cancer risk factors and was also associated with a hormonal environment during pregnancy favoring future breast cancer development and progression.en
dc.identifier.citationPLoS ONE (2012), vol. 7(7): e40199en
dc.identifier.issn1932-6203
dc.identifier.otherFRIDAID 961503
dc.identifier.otherhttp://dx.doi.org/10.1371/journal.pone.0040199
dc.identifier.urihttps://hdl.handle.net/10037/5015
dc.identifier.urnURN:NBN:no-uit_munin_4715
dc.language.isoengen
dc.publisherPublic Library of Science (PLoS)en
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en
dc.titleBirth Weight, Breast Cancer and the Potential Mediating Hormonal Environmenten
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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