Recent additions

  • Novel insights into the fenestrated scavenger endothelium of the liver sinusoid 

    Holte, Christopher Florian (Doctoral thesis; Doktorgradsavhandling, 2024-03-22)
    <p>The sinusoids (specialized small blood vessels) of the liver are covered by endothelium (blood vessel wall cells) with open transcellular pores (holes that go from one side to the other) called fenestrations. This allows for efficient bidirectional transfer of solutes between the blood and the hepatocytes (main metabolic liver cell). These fenestrations can disappear or reduce in number and size ...
  • Cytomegalovirus infection and dexamethasone effects in liver sinusoidal endothelial cells 

    Kyrrestad, Ingelin (Doctoral thesis; Doktorgradsavhandling, 2024-03-15)
    The liver is a major organ in the body's defense against blood-borne pathogens. It acts as a filter for the blood and is a central site for immune responses, and a central hub for various metabolic processes. Within the liver, an extensive network of small blood vessels, the hepatic sinusoids, are key sites for the exchange of nutrients and waste products between the blood circulation and the liver ...
  • Aspects of brain health and pain tolerance in a general population 

    Melum, Tonje Anita (Doctoral thesis; Doktorgradsavhandling, 2024-02-15)
    Pain is a major burden both for affected individuals and for society. While it has been established that processing in the brain is key to the experience of pain, most of the research is done in healthy volunteers or patients with specific pain conditions. Less is known about how the status of the brain may relate to pain sensitivity in the general population. While clinical pain can differ because ...
  • Microbial Adaptation - Responses to External Cues 

    Storflor, Merete (Doctoral thesis; Doktorgradsavhandling, 2024-02-09)
    Bacteria can adapt to various environments because they efficiently sense and respond to external cues. This is exemplified by antibiotic resistance, a leading cause for death on a global scale. Antibiotics exert a selection pressure on bacteria, where improper use can inadvertently select for antibiotic resistance. Dissemination of antibiotic resistance throughout bacterial populations can occur ...
  • Panoramic radiograph analyses for early detection of osteoporosis in the population of Northern Norway 

    Teterina, Anna (Doctoral thesis; Doktorgradsavhandling, 2024-01-26)
    Osteoporosis is a chronic disease affecting bone tissue that may lead to fractures from minor accidents. Roughly 20% of females and 6 % of males have osteoporosis after age 50, but the disease might be present at a younger age. Early diagnosis is challenging because the disease has no symptoms. Dental radiography is a frequent examination that might be useful for early osteoporosis screening at ...
  • Energetics, energy availability and Relative Energy Deficiency in Sport (REDs) in female football players - Methodological perspectives and research implications 

    Tutu Dasa, Marcus Småvik (Doctoral thesis; Doktorgradsavhandling, 2024-01-18)
    <p><i>Background:</i> For athletes, it is imperative that energy intake adequately addresses the total energy requirements inherent to their specific sport. Low energy availability, which is the failure to provide the body with adequate energy to sustain physiological homeostasis, may potentially result in Relative Energy Deficiency in Sport (REDs). This is a syndrome that can have detrimental health ...
  • Exploring mitochondrial quality control mechanisms and mitochondria-lipid droplet interactions in cardiac cell models 

    Godtliebsen, Gustav (Doctoral thesis; Doktorgradsavhandling, 2024-01-11)
    Mitochondria are the main energy producing units (organelles) in cardiac cells (cardiomyocytes). Cardiomyocytes have especially high mitochondrial content due to the heart’s continuous energy-intensive pumping. Studies of heart disease (such as heart failure) indicate that mitochondrial dysfunction is central to disease progression. There are many cellular mechanisms that protect mitochondria from ...
  • Decision-making in Norwegian child welfare services- The impact of case characteristics on decision-making from referral to concluded investigation 

    Rustad, Kirsten Buck (Doctoral thesis; Doktorgradsavhandling, 2024-01-18)
    The thesis explores how case characteristics impact decision-making in the Norwegian child welfare service. The following decisions were studied: i) the initial screening decision, ii) the extent of an investigation, and iii) the dismissal of cases when the family refuse interventions. Previous research has identified differences in case trajectory between agencies. The impact of case characteristics ...
  • Prolonged Cardiopulmonary Resuscitation in Accidental Hypothermia: Physiological and pathophysiological effects of cardiopulmonary resuscitation (CPR) in hypothermia regarding hemodynamics, oxygen transport and regional blood flow 

    Valkov, Sergei (Doctoral thesis; Doktorgradsavhandling, 2023-12-21)
    This thesis was aimed to examine the physiological and pathophysiological effects of 3 hours continuous cardiopulmonary resuscitation (CPR) at 27°C concerning hemodynamics, oxygen transport, and regional blood flow. We aimed to explore mechanisms responsible for the successful resuscitation of accidental hypothermia victims in hypothermic cardiac arrest (HCA) and evaluate their value during prolonged ...
  • Dementia Disease Initiation: Demographically adjusted norms based on Scandinavian samples and comparison with published norms from North America 

    Espenes, Johan Jacob (Doctoral thesis; Doktorgradsavhandling, 2023-12-14)
    <p><i>Background:</i> Norms are necessary for interpreting neuropsychological test scores. In Norway and Sweden, there is a lack of local norms on neuropsychological tests. Consequently, Scandinavians are frequently norm-referenced to participants from North America tested decades prior. However, factors such as time of assessment, language, population differences in average performance on cognitive ...
  • Measuring socioeconomic position in studies of health inequalities 

    Lindberg, Marie Hella (Doctoral thesis; Doktorgradsavhandling, 2024-02-08)
    <p>There is a consistent finding that the higher the socioeconomic position (SEP), the better the health. The choice of SEP indicator is crucial in explaining these socioeconomic inequalities. However, a poorly motivated use of SEP indicators prevails in the literature on social health inequalities, hampering the transparency and comparability across studies. Its primary aim is to explore different ...
  • Human Exposure to PFAS and Other Anthropogenic Organofluorine Chemicals in Tromsø between 1986 and 2015 

    Cioni, Lara (Doctoral thesis; Doktorgradsavhandling, 2023-12-06)
    Summary In the last century, there has been a dramatic increase in chemical production and number and diversity of chemicals produced. Especially, organofluorine chemistry has increased its importance due to applications in pharmaceuticals, agrochemicals, refrigerant gases and in consumer products and industry with fluoropolymers and per- and polyfluoroalkyl substances (PFAS). PFAS are receiving ...
  • Family focus in mental health and social services for adults: Supporting minor children of parents in challenging life situations 

    Kristensen, Kjersti Bergum (Doctoral thesis; Doktorgradsavhandling, 2023-11-30)
    Parental mental illness, parents’ loss of ability to work and family poverty affect children and put them at risk for adverse life outcomes. Support for and attendance to minor children and parenting in adult mental health and social services should therefore be an incorporated practice. The main aim of this thesis was to investigate the extent and quality of a family focus in these adult services. ...
  • Blood biomarkers and Type 2 Diabetes Mellitus - Repeated measurements of blood biomarkers in Type 2 Diabetes Mellitus cases and controls; longitudinal assessments and associations 

    Allaoui, Giovanni (Doctoral thesis; Doktorgradsavhandling, 2023-11-24)
    Type 2 diabetes (T2DM) is a chronic metabolic disease and is characterised by insulin resistance and insufficient insulin secretion, resulting in hyperglycaemia. The prevalence of diabetes was estimated to be 10.5% in 2021, globally. T2DM is associated with several complications, including cardiovascular complications, degradation of nerve fibres and eyesight, and impaired kidney function, especially ...
  • Men's Underrepresentation in Communal Occupations: A Social-Developmental Approach 

    Olsen, Marte (Doctoral thesis; Doktorgradsavhandling, 2023-11-23)
    This dissertation addresses psychological factors that contribute to the underrepresentation of men in communal occupations (i.e., occupations associated with communal traits, e.g., nurse), based on the theoretical perspectives from the developmental theory of occupational aspirations (Gottfredson, 1981) and the model of achievement-related choices (Eccles et al., 1983). The underrepresentation of ...
  • Secondary Fracture Prevention and Forearm Fracture Epidemiology. NoFRACT – The Norwegian Capture the Fracture Initiative 

    Andreasen, Camilla (Doctoral thesis; Doktorgradsavhandling, 2023-11-17)
    <p><i>Background:</i> Osteoporosis and fragility fractures are common, and a burden to patients and society. Forearm fracture are a common fragility fracture. Anti-osteoporotic drugs (AODs) that reduce the risk of future fracture are available, but under 20% of fragility fracture patients receive AODs. To close this treatment gap Fracture Liaison Services (FLS) with systematic identification, ...
  • Early Markers of Metabolic Dysregulation in Obese Individuals - Identification at Baseline and Effect of Modest Weight Loss 

    Isaksen, Victoria Therese (Doctoral thesis; Doktorgradsavhandling, 2023-11-15)
    <p><i>Background:</i> Evidence suggests that the link between obesity and chronic lifestyle disease is chronic, low-grade inflammation. Leptin and adiponectin play principal roles in inducing inflammation and promoting insulin resistance, resulting in metabolic syndrome. Our study aimed to find clinically feasible biologic markers to identify metabolically dysregulated obese individuals and to study ...
  • Deciphering human cell type enriched transcriptomes across tissue types and the functional study of the endothelial enriched protein KANK3 

    Öling, Sofia Maria (Doctoral thesis; Doktorgradsavhandling, 2023-11-13)
    The identification of cell type-specific genes and their modification under certain conditions is essential for our understanding of the human body. Such knowledge also allows us to study the function of uncharacterised genes in the correct cell type. Single-cell RNA sequencing (scRNAseq) can be used to profile different cell types, but cell removal and processing can introduce artifacts. In the ...
  • Temperature-dependent effects of phosphodiesterase inhibitors for cardiovascular support in hypothermic patients - Effects on cellular elimination of cAMP and cGMP 

    Kuzmiszyn, Adrina Kalasho (Doctoral thesis; Doktorgradsavhandling, 2023-11-10)
    Hypothermia-induced cardiac dysfunction (HCD), commonly seen during rewarming, is one of the feared complications of accidental hypothermia. Animal studies with phosphodiesterase (PDE) inhibitors and sodium nitroprusside have demonstrated positive effects on reversing HCD. These medications act by indirectly increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine ...
  • HPV mRNA and HPV DNA Tests in Cervical Cancer Screening 

    Rad, Amir (Doctoral thesis; Doktorgradsavhandling, 2023-11-09)
    <p><i>Background:</i> Cervical cancer is the fourth most prevalent cancer in women worldwide. Cervical cancer screening (cytology or human papillomavirus [HPV] testing) and HPV vaccination can decrease cervical cancer incidence and mortality. However, because cytology-based screening has a low sensitivity to detect high-grade cervical lesions, several countries have replaced it with HPV test-based ...

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