Now showing items 1536-1555 of 2767

    • Longitudinal Associations Between Cumulative Physical Activity and Change in Structure and Function of the Left Side of the Heart: The Tromsø Study 2007–2016 

      Heitmann, Kim Arne; Welde, Boye; Løchen, Maja-Lisa; Stylidis, Michael; Schirmer, Henrik; Morseth, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-12)
      Background: Current knowledge about the relationship between physical activity (PA) and cardiac remodeling is mainly derived from cross-sectional studies of athletes, and there is a knowledge gap of this association in the general adult and elderly population. Therefore, we aimed to explore the longitudinal association between cumulative PA and change in cardiac structure and function in a general ...
    • Longitudinal changes in vitamin D concentrations and the association with type 2 diabetes mellitus: the Tromsø Study 

      Allaoui, Giovanni; Rylander, Charlotta; Fuskevåg, Ole Martin; Averina, Maria; Wilsgaard, Tom; Brustad, Magritt; Jorde, Rolf; Berg, Vivian (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-02)
      Aim We aimed to investigate the relationship between pre- and post-diagnostic 25-hydroxyvitamin D (25(OH)D) concentrations and type 2 diabetes (T2DM) over a period of 30 years in individuals who developed T2DM compared to healthy controls.<p> <p>Methods This case–control study included 254 participants with blood samples collected at fve diferent time-points (T1–T5) between 1986 and 2016. Of the ...
    • The Longitudinal Course of Prospectively Recorded Patient-reported Outcomes in Prostate Cancer Patients Treated with Surgery and Salvage Radiotherapy 

      Hjelle, Line Veronika; Sælen, Marie; Aarsæther, Erling Johan; Knutsen, Tore; Andersen, Sigve; Bentzen, Anne Gry; Richardsen, Elin; Wilsgaard, Tom; Fosså, Sophie Dorothea; Haugnes, Hege Sagstuen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-13)
      Background - Patient-reported outcome measures (PROMs) after prostate cancer (PC) treatment, including both radical prostatectomy (RP) and salvage radiation therapy (SRT), are under-reported.<p> <p>Objective - To investigate PROMs longitudinally from before SRT until 18 mo after SRT for men treated with contemporary treatment modalities.<p> <p>Design, setting, and participants - This prospective, ...
    • Longitudinal determinants of insomnia among patients with alcohol use disorder 

      Bolstad, Ingeborg; Toft, Helge; Lien, Lars; Moe, Jenny Skumsnes; Rolland, Benjamin; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-07)
      Insomnia is common among patients with AUD and can impair quality of life and cognitive functioning, as well as cause psycho-social problems and increased risk of relapse. Nonetheless, determinants of insomnia in patients with AUD have scarcely been studied. We aimed to examine prevalence and development of self-perceived insomnia among inpatients in treatment for AUD, and to examine factors in ...
    • Longitudinal relationships between habitual physical activity and pain tolerance in the general population 

      Årnes, Anders; Nielsen, Christopher Sivert; Stubhaug, Audun; Fjeld, Mats Kirkeby; Johansen, Aslak; Morseth, Bente; Strand, Bjørn Heine; Wilsgaard, Tom; Steingrímsdóttir, Ólöf Anna (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-24)
      Physical activity (PA) might influence the risk or progression of chronic pain through pain tolerance. Hence, we aimed to assess whether habitual leisure-time PA level and PA change affects pain tolerance longitudinally in the population. Our sample (n = 10,732; 51% women) was gathered from the sixth (Tromsø6, 2007–08) and seventh (Tromsø7, 2015–16) waves of the prospective population-based Tromsø ...
    • Longitudinal Transcriptomic Analysis of Human Cortical Spheroids Identifies Axonal Dysregulation in the Prenatal Brain as a Mediator of Genetic Risk for Schizophrenia 

      Akkouh, Ibrahim Ahmed; Ueland, Thor; Szabo, Attila; Hughes, Timothy; Smeland, Olav Bjerkehagen; Andreassen, Ole; Requena Osete, Jordi; Djurovic, Srdjan (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-03)
      BACKGROUND: Schizophrenia (SCZ) has a known neurodevelopmental etiology, but limited access to human prenatal brain tissue hampers the investigation of basic disease mechanisms in early brain development. Here, we elucidate the molecular mechanisms contributing to SCZ risk in a disease-relevant model of the prenatal human brain.<p> <p>METHODS: We generated induced pluripotent stem cell–derived ...
    • Looking for Common Ground: Marine Living Resource Development in Alaska and Northern Norway in the Context of the Blue Economy 

      Tsiouvalas, Apostolos; Stoeva, Gergana; Raspotnik, Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-30)
      Although the concept of the blue economy was created by the Small Island Developing States, its relevance extends to any coastal region around the globe, making the engagement of both state and corporate actors imperative. At the core of the blue economy framework stands the incorporation of ocean values and services into economic modeling and governance. Sustainable fisheries and aquaculture are ...
    • Loss of species and genetic diversity during colonization: Insights from acanthocephalan parasites in northern European seals 

      Sromek, Ludmila; Ylinen, Eeva; Kunnasranta, Mervi; Maduna, Simo; Sinisalo, Tuula; Michell, Craig T.; Kovacs, Kit M.; Lydersen, Christian; Ieshko, Evgeny; Andrievskaya, Elena; Alexeev, Vyacheslav; Leidenberger, Sonja; Hagen, Snorre; Nyman, Tommi (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-19)
      Studies on host–parasite systems that have experienced distributional shifts, range fragmentation, and population declines in the past can provide information regarding how parasite community richness and genetic diversity will change as a result of anthropogenic environmental changes in the future. Here, we studied how sequential postglacial colonization, shifts in habitat, and reduced host ...
    • Loss of statin treatment years during pregnancy and breastfeeding periods in women with familial hypercholesterolemia 

      Klevmoen, Marianne; Bogsrud, Martin Prøven; Retterstøl, Kjetil; Svilaas, Tone; Vesterbekkmo, Elisabeth Kleivhaug; Hovland, Anders; Berge, Christ; van Lennep, Jeanine Roeters; Holven, Kirsten Bjørklund (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-03)
      Background and aims Women with heterozygous familial hypercholesterolemia (FH) are recommended to initiate statin treatment at the same age as men (from 8 to 10 years of age). However, statins are contraindicated when pregnancy is planned, during pregnancy and breastfeeding. The aim of the study was to determine the duration of pregnancy-related off-statin periods and breastfeeding in FH ...
    • Lost in translation: from the university's quality assurance system to student evaluation practice 

      Borch, Iris Helene (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-07)
      Student course evaluation is a mandatory part of quality assurance systems in Norwegian higher education, aiming to enhance educational quality. However, several studies report that student course evaluation mainly is used for quality assurance and not for quality enhancement. Drawing upon translation theory, this paper analyses how the quality assurance system (QAS) that regulates evaluation, the ...
    • Lost relation between blood pressure and serum 25-hydroxyvitamin D 

      Jorde, Rolf; Grimnes, Guri (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-26)
      Background: Low serum 25-hydroxyvitamin D (25(OH)D) levels have consistently been associated with hypertension. During the last decades there has been an unexplained reduction in blood pressure (BP) in Western countries. We therefore examined the relation between serum 25(OH)D and BP in the 7th survey of the Tromsø study 2015/2016.<p> <p>Methods: Blood pressure and serum 25(OH)D were measured and ...
    • Love across borders. Construction of gender equality and Norwegianness in Russian-Norwegian families. 

      Lotherington, Ann Therese (Chapter; Bokkapittel, 2020)
      More than 12 percent of the Norwegian population has immigration background, and immigrants play important parts in changing the Norwegian society from a seemingly homogenous to an evidently heterogeneous society. The Norwegian diversity policy was developed to encounter the challenges this represents. The goal of the policy is to create a society taking into account the individual’s right to be ...
    • Lovgivning av betydning for arbeid og arbeidsinkludering 

      Kane, Aina Aune; Köhler-Olsen, Julia (Chapter; Bokkapittel, 2019)
      I dette kapittelet rettes søkelyset mot arbeidsgivernes og arbeidstakernes rettigheter og plikter når det gjelder arbeidsinkludering; å få arbeid, beholde arbeid eller komme tilbake i arbeid. Temaer som vil bli belyst er retten til likebehandling og forbud mot diskriminering i arbeidslivet, samt Navs ansvarsområder innenfor arbeidsinkludering med tanke på de ytelser og bistandsformer som forvaltes ...
    • Low BMI, but not high BMI, influences the timing of puberty in boys 

      Oehme, Ninnie Helen Bakken; Roelants, Mathieu; Bruserud, Ingvild Særvold; Madsen, Andre; Bjerknes, Robert; Rosendahl, Karen; Juliusson, Pétur Benedikt (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-05)
      Background - Previous studies investigating the association between weight status and onset of puberty in boys have been equivocal. It is currently unclear to what extent weight class influences puberty onset and progression.<p> <p>Objectives - To explore the relationship between degree of sexual maturation and anthropometric measures in Norwegian boys.<p> <p>Methods - The following endpoints ...
    • Low Concordance Between T-Cell Densities in Matched Primary Tumors and Liver Metastases in Microsatellite Stable Colorectal Cancer 

      Johansen Dagenborg, Vegard; Marshall, Serena Elizabeth; Grzyb, Krzyzstof; Fretland, Åsmund Avdem; Lund-Iversen, Marius; Mælandsmo, Gunhild Mari; Hansen Ree, Anne; Edwin, Bjørn; Yaqub, Sheraz; Flatmark, Kjersti (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-09)
      Background: The subtype, density and location of tumor infiltrating T-cells are being explored as prognostic and predictive biomarkers in primary colorectal cancer (pCRC) and colorectal liver metastases (CLM). Very limited data exist comparing findings in pCRC and matched CLM.<p> <p>Patients and methods: Fifty-eight patients with available pCRC and matched CLM (57/58 microsatellite stable) were ...
    • Low maternal capital predicts life history trade-offs in daughters: Why adverse outcomes cluster in individuals 

      Wells, Jonathan C.K.; Cole, Tim J.; Cortina-Borja, Mario; Sear, Rebecca; Leon, David Adrew; Marphatia, Akanksha A.; Murray, Joseph; Wehrmeister, Fernando César; Oliveira, Paula D.; Goncalves, Helen; Oliveira, Isabel O.; Menezes, Ana Maria B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-31)
      <i>Background</i>: Some individuals appear prone to multiple adverse outcomes, including poor health, school dropout, risky behavior and early reproduction. This clustering remains poorly understood. Drawing on evolutionary life history theory, we hypothesized that maternal investment in early life would predict the developmental trajectory and adult phenotype of female offspring. Specifically, we ...
    • Low proficiency does not mean ab initio: A methodological footnote for linguistic transfer studies 

      Puig-Mayenco, Eloi; Rothman, Jason (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-17)
      The goal of this brief article is to highlight a specific methodological consideration pertaining to the examination of linguistic transfer in sequential language acquisition: When and how can transfer be meaningfully disentangled from issues pertaining to developmental trajectories of the target language? While this methodological issue is relevant for all transfer studies irrespective of learner ...
    • Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness 

      Andreou, Dimitrios; Steen, Nils Eiel; Jørgensen, Kjetil Nordbø; Smelror, Runar Elle; Wedervang-Resell, Kirsten; Nerland, Stener; Westlye, Lars Tjelta; Nærland, Terje; Myhre, Anne Margrethe; Joa, Inge; Reitan, Solveig Merete Klæbo; Vaaler, Arne; Morken, Gunnar; Bøen, Erlend; Elvsåshagen, Torbjørn; Boye, Birgitte; Malt, Ulrik Fredrik; Aukrust, Pål; Skrede, Silje; Kroken, Rune Andreas; Johnsen, Erik; Djurovic, Srdjan; Andreassen, Ole; Ueland, Thor; Agartz, Ingrid (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-11)
      Background - Both neurodegenerative and neurodevelopmental abnormalities have been suggested to be part of the etiopathology of severe mental illness (SMI). Neuron-specific enolase (NSE), mainly located in the neuronal cytoplasm, may indicate the process as it is upregulated after neuronal injury while a switch from non-neuronal enolase to NSE occurs during neuronal maturation.<p> <p>Methods - ...
    • Lower conversion rate with robotic assisted rectal resections compared with conventional laparoscopy; a national cohort study 

      Myrseth, Elisabeth; Nymo, Linn Såve; Gjessing, Petter Fosse; Kørner, Hartwig; Kvaløy, Jan Terje; Norderval, Stig (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-18)
      <i>Background</i> - Conversion from laparoscopic to open access colorectal surgery is associated with a poorer postoperative outcome. The aim of this study was to assess conversion rates and outcomes after standard laparoscopic rectal resection (LR) and robotic laparoscopic rectal resection (RR).<br><br> <i>Methods</i> - A national 5-year cohort study utilizing prospectively recorded data on ...
    • LS-Net: fast single-shot line-segment detector 

      Nguyen, Van Nhan; Jenssen, Robert; Roverso, Davide (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-29)
      In unmanned aerial vehicle (UAV) flights, power lines are considered as one of the most threatening hazards and one of the most difficult obstacles to avoid. In recent years, many vision-based techniques have been proposed to detect power lines to facilitate self-driving UAVs and automatic obstacle avoidance. However, most of the proposed methods are typically based on a common three-step approach: ...