• The efficacy of botulinum toxin A treatment for tension-Type or cervicogenic headache: A systematic review and meta-Analysis of randomized, placebo-controlled trials 

      Roland, Sissel Breivold; Pripp, Are Hugo; Msomphora, Mbachi Ruth; Kvarstein, Gunnvald (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-07)
      Objectives - The pathogeneses of chronic tension-type headache (CTTH) and cervicogenic headache (CEH) are not well established. Peripheral activation or sensitization of myofascial nociceptors is suggested as a potential mechanism and injections of botulinum toxin (BONTA) have thus been used in the treatment for both headache conditions. BONTA inhibits the release of acetylcholine at the neuromuscular ...
    • Mediators of pain and physical function in female and male patients with chronic pain 

      Danielsson, Lena Elsa; Kvarstein, Gunnvald; Bergvik, Svein (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-19)
      <i>Purpose</i>: Chronic pain is often multifactorial and accompanied by psychological distress, catastrophizing thoughts, reduced physical function, and socio-economic worries. In this explorative study, we investigated potential mediators in the relationships of psychological and demographic variables with chronic pain and physical function in women and men.<p><p> <i>Patients and Methods</i>: ...
    • An observational post-authorization safety study (PASS) of naloxegol drug utilization in four European countries 

      Kvarstein, Gunnvald; Kindlundh-Högberg, Anna MS; Ould Setti, Mounir; Namane, Rafik; Muzwidzwa, Ruvimbo; Richter, Hartmut; Hakkarainen, Katja M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-15)
      Purpose - Naloxegol has been shown to be an efficient alternative to treat opioid-induced constipation (OIC). This study aimed at describing the characteristics of naloxegol users and assessing patterns of naloxegol use and associated factors.<p> <p>Methods - This drug utilization cohort study used observational registry data on patients newly prescribed naloxegol in four European countries. ...
    • Postoperative opioids and risk of respiratory depression - A cross-sectional evaluation of routines for administration and monitoring in a tertiary hospital 

      Andersen, Karoline Kolås; Kvarstein, Gunnvald (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-28)
      Objectives<p> Opioids are the most potent analgesics in the treatment of postoperative pain. Respiratory depression is, however, a serious side effect. The aims of this study were to evaluate current practice and routines for post-operative administration of opioids in a Norwegian university hospital and to evaluate whether the clinical safeguards adequately protected patients’ safety regarding risk ...
    • Rettighetsvurdering og kvalitet på henvisninger - grad av samsvar mellom fire smertesentre 

      Stedenfeldt, Mona; Kvarstein, Gunnvald; Schjødt, Borrik; Johansen, Aslak; Berntsen, Anne Gina Schie; Brautaset, Astrid; Halsteinli, Vidar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-24)
      <p><i>BAKGRUNN - </i>Langvarige smerter er et utbredt helseproblem. De fire regionale tverrfaglige smertesentrene i Norge mottar årlig ca. 5 000 henvisninger fra fastleger og spesialisthelsetjenesten. Et likeverdig tilbud tilsier at henvisninger bør vurderes likt. Formålet med studien var å evaluere grad av samsvar mellom smertesentrenes inntaksteam i vurdering av kvalitet på mottatte henvisninger ...