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norskBlar i tittel Fakultet for naturvitenskap og teknologi
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Synthesis of 5-,6-, and 7-membered heterocycles from barbituric acid derivatives
(Master thesis; Mastergradsoppgave, 2011-06-10)SUMMARY A new procedure has been developed for the synthesis of barbituric acid derivatives. The reactions were performed under solvent free conditions without any catalyst. Employing this synthetic route, a large number of chalconoids and 5-,6-, and 7-membered heterocycles have been successfully synthesized in a very short time. The chalconoids have been synthesized from a barbituric derivative ... -
Synthesis of a novel class of antitubercular peptidomimetics based on β-aminoboronates.
(Doctoral thesis; Doktorgradsavhandling, 2012-11-16)The unique properties of antimicrobial peptides have attracted the attention of chemists since the 1970’s. This class of compounds provides additional tools in the treatment of infections and the work described in this thesis was therefore focused on the synthesis of short peptidomimetics on the basis of modified amino acids and evaluation of their antimicrobial activity. The compounds of choice ... -
Synthesis of Indoles and Pyrroles Utilizing Iridium Carbenes Generated from Sulfoxonium Ylides
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-20)Metal carbenes can undergo a myriad of synthetic transformations. Sulfur ylides are potential safe precursors of metal carbenes. Herein, we report cascade reactions that involve carbenoids derived from sulfoxonium ylides for the efficient and regioselective synthesis of indoles and pyrroles. The tandem action of iridium and Brønsted acid catalysts enables rapid assembly of the heterocycles from ... -
Synthesis of phorbazoles and breitfussins analogues
(Master thesis; Mastergradsoppgave, 2016-05-18)Breitfussins are a group of a closely related heterocyclic compounds. They consist of a tetracyclic structure with an indole, an oxazole and a pyrrole. The breitfussins exhibit interesting biological activity and analogues synthesis and biological evaluation is ongoing. Phorbazoles have a structural similarity with breitfussins in which a phenol replaces the indole. As a part of this, synthesis of ... -
Synthesis of Potential Metallo-beta-Lactamase Inhibitors
(Master thesis; Mastergradsoppgave, 2011-11-15) -
Synthesis of Potential Metallo-β-Lactamase Inhibitors
(Master thesis; Mastergradsoppgave, 2012-06-04)Oppgaven omhandler syntesen av mulige metallo-beta-lactamaser inhibitorer. -
Synthesis of Sterically Hindered Macrocyclic Ligands via Demetalation of Metallocorroles
(Doctoral thesis; Doktorgradsavhandling, 2016-06-07)Despite important developments in synthetic corrole chemistry, the field has long been handicapped by the lack of procedures for demetalation of metallocorroles. This thesis presents general demetalation methods for metallocorroles. A reductive demetalation method was developed using concentrated H2SO4 with 5-200 equivalent of FeCl2 or SnCl2 as a reducing agent. The method proved to be quite general ... -
Synthesis of thiol-appended gold and rhenium corroles as potential nanoconjugants for gold nanoparticles
(Master thesis; Mastergradsoppgave, 2023-06-10)Photodynamic therapy (PDT) today is an established treatment for a variety of cancers as well as various dermatological conditions, macular degeneration and bacterial and other infections. Treatment involves the administration of a photosensitizer, typically a porphyrin, followed by irradiation with light. The photoexcited sensitizer transfers its excess energy to oxygen in the affected tissue, ... -
Synthesis of XTH inhibitors
(Master thesis; Mastergradsoppgave, 2019-05-15)XTH er en gruppe enzymer som ble oppdaget tidlig på 90 tallet og muligens er involvert i Cuscuta infeksjonen av tomater. En nylig studie gjort ved arktisk og marin biologi UIT viser at Brilliant Blue R250 fungerer som en god inhibitor mot disse enzymene. I dette prosjektet ble det fokusert på å syntetisere strukturelt like molekyler for å potensielt øke vannløseligheten og inhibitoraktiviteten. ... -
Synthesis of β-substituted β-aminoboronates
(Master thesis; Mastergradsoppgave, 2013-05)Recent work at the University of Tromsø has uncovered new α-substituted α- and β-aminoboron containing peptidomimetics that shows antimicrobial, antifungal and antitubercular activity in addition to kinase inhibition and promotion. As a continuation of this work a new approach for the synthesis of β-substituted β-aminoboronates has been developed. The approach involves the non-stereospecific ... -
Synthesis, Spectroscopy, Electrochemistry and DFT of Electron-Rich Ferrocenylsubphthalocyanines
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-01)A series of novel ferrocenylsubphthalocyanine dyads Y-BSubPc(H)<sub>12</sub> with ferrocenylcarboxylic acids Y-H = (FcCH<sub>2</sub>CO<sub>2</sub>-H), (Fc(CH<sub>2</sub>)<sub>3</sub>CO<sub>2</sub>-H) or (FcCO(CH<sub>2</sub>)<sub>2</sub>CO<sub>2</sub>-H) in the axial position were synthesized from the parent Cl-BSubPc(H)<sub>12</sub> via an activated triflate-SubPc intermediate. UV/Vis data revealed ... -
Synthetic analogs of stryphnusin isolated from the marine sponge Stryphnus fortis inhibit acetylcholinesterase with no effect on muscle function or neuromuscular transmission
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-09)The marine secondary metabolite stryphnusin (1) was isolated from the boreal sponge Stryphnus fortis, collected off the Norwegian coast. Given its resemblance to other natural acetylcholinesterase antagonists, it was evaluated against electric eel acetylcholinesterase and displayed inhibitory activity. A library of twelve synthetic phenethylamine analogs, 2a–7a and 2b–7b, containing tertiary and ... -
Synthetic aperture radar compact polarimetry for sea ice surveillance
(Master thesis; Mastergradsoppgave, 2015-06-26)The focus of this thesis is to investigate the use of synthetic aperture radar (SAR) compact polarimetry for studies of sea ice. Data obtained from quad-polarimetric SAR systems have already been studied extensively for sea ice monitoring. This thesis focuses on finding parallels to quad-polarimetric features from the compact-polarimetric data. This is achieved through the reconstruction of a pseudo ... -
Synthetic Aperture Radar Remote Sensing of Operational Platform Produced Water Releases
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-03)Oil spill detection services based on satellite synthetic aperture radar (SAR) frequently detect oil slicks close to platforms due to legal releases of produced water. Separating these slicks from larger releases, e.g., due to accidental leakage is challenging. The aim of this work is to investigate the SAR characteristics of produced water, including the typical appearance in HH/VV data, possible ... -
Synthetic aperture ultrasound imaging with application to interior pipe inspection
(Doctoral thesis; Doktorgradsavhandling, 2012-09-07)This thesis is concerned with synthetic aperture focusing of ultrasonic pulse-echo measurements, with application to multilayered media and cylindrical structures. The work is motivated by the need for accurate methods for non-destructive testing of pipelines, particularly water distribution pipelines. By improving the lateral resolution in ultrasonic measurements, the synthetic aperture algorithms ... -
Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
A Synthetic Route to Quaternary Pyridinium Salt-Functionalized Silsesquioxanes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)A synthetic route to potentially biocidal silsesquioxanes functionalized by quaternary pyridinium functionalities has been developed. N-Alkylation reactions of the precursor compounds 4-(2-(trimethoxysilyl)ethyl)-pyridine (5) and 4-(2-trichloro-silylethyl)pyridine (6) with iodomethane, n-hexylbromide, and n-hexadecylbromide cleanly afforded the corresponding N-alkylpyridinium salts (7–10). The ... -
Synthetic wavelength scanning interferometry for 3D surface profilometry with extended range of height measurement using multi-colour LED light sources
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-05)We report three-dimensional surface profilometry with extended range of height measurements using synthetic wavelength scanning interferometry without tunable filters, wavelength-tuning lasers, grating elements. We have used inexpensive multiple colour light emitting diodes (LEDs) and operate them sequentially one by one or combination of two or more colours simultaneously to visualize synthetic ... -
System for measuring, storing, and visualizing pressure of patients dependent on a tracheostomy tube
(Mastergradsoppgave; Master thesis, 2023-07-03)Wrongful removal of tracheostomy tubes is often associated with high drama for all parties involved. With children's repository system being under-documented, there is no consensus on when these tubes should be removed for children at different ages. Measuring the pressure generated by these children can help doctors make better decisions and give the tools for helping medical researchers reach a ... -
System upgrade and data evaluation of the AIRIS riometer
(Master thesis; Mastergradsoppgave, 2016-06-06)The focus of this thesis has been to investigate how to improve the AIRIS data. This has been done by first of all giving the riometer system an overhaul, checking the wiring and receivers as well as upgrading the riometer computer harddisk. As there has been a lot of issues occurring along the way, the focus finally went to pinpointing exactly what is causing the data quality to be poor and coming ...
