Blar i forfatter Artikler, rapporter og annet (medisinsk biologi) "Ausbacher, Dominik"

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    • Amphipathic barbiturates as marine product mimics with cytolytic and immunogenic effects on head and neck squamous cell carcinoma cell lines 

      von Hofsten, Susannah; Langer, Manuel K; Korelin, Katja; Norvoll Magnussen, Synnøve; Ausbacher, Dominik; Anderssen, Trude; Salo, Tuula; Strøm, Morten B.; Bayer, Annette; Al-Samadi, Ahmed; Berge, gerd (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-30)
      The incidence of head and neck squamous cell carcinoma (HNSCC) is increasing and the conventional treatments for this form of cancer can be tough. Despite the success of existing immunotherapies in some HNSCC patients, many do not respond to this type of treatment. Thus, the development of novel anti-cancer therapies should be prioritized. In the current study, the anticancer activity of a panel ...

    • The Marine Natural Product Mimic MHP88 Shows Anticancer Activity and has the Potential to Cause Immunogenic Cell Death 

      von Hofsten, Susannah; Norvoll Magnussen, Synnøve; Ausbacher, Dominik; Paulsen, Marianne Hagensen; Bayer, Annette; Strøm, Morten B.; Berge, Gerd (Conference object; Konferansebidrag, 2020-03)
      The marine natural product mimic MHP 88 is a novel synthetic molecule based on unique structures found in molecules from an arctic marine bryozoan. Initial studies showed that MHP88 kills cancer cells efficiently, but is not hemolytic. In this study, we look closer at the mode of death induced by MHP88 in oral cancer (HSC-3) and lymphoma (Ramos) cell lines. Immunogenic cell death (ICD) is a mode of ...

    • The marine natural product mimic MPM-1 is cytolytic and induces DAMP release from human cancer cell lines 

      von Hofsten, Susannah; Paulsen, Marianne Hagensen; Magnussen, Synnøve; Ausbacher, Dominik; Kranz, Mathias; Bayer, Annette; Strøm, Morten Bøhmer; Berge, Gerd (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-16)
      Bioprospecting contributes to the discovery of new molecules with anticancer properties. Compounds with cytolytic activity and the ability to induce immunogenic cell death can be administered as intratumoral injections with the aim to activate anti-tumor immune responses by causing the release of tumor antigens as well as damage-associated molecular patterns (DAMPs) from dying cancer cells. In ...