Browsing Artikler, rapporter og annet (medisinsk biologi) by Author "Csoboz, Balint"

Now showing items 1-4 of 4

    • Merkel cell polyomavirus and non-Merkel cell carcinomas: Guilty or circumstantial evidence? 

      Csoboz, Balint; Rasheed, Kashif; Sveinbjørnsson, Baldur; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-28)
      Merkel cell polyomavirus (MCPyV) is the major causative factor of the rare but aggressive cancer, Merkel cell carcinoma (MCC). Two characteristics of MCPyV‐positive MCCs are integration of the viral genome and expression of a truncated version of one of its oncogenic proteins, namely large T antigen. The strong association of MCPyV with MCC development has incited researchers to further investigate ...

    • Modulation of Plasma Membrane Composition and Microdomain Organization Impairs Heat Shock Protein Expression in B16-F10 Mouse Melanoma Cells 

      Crul, Tim; Csoboz, Balint; Gombos, Imre; Marton, Annamaria; Peter, Maria; Balogh, Gabor; Vizler, Csaba; Szente, Lajos; Vigh, Laszlo (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-12)
      The heat shock response (HSR) regulates induction of stress/heat shock proteins (HSPs) to preserve proteostasis during cellular stress. Earlier, our group established that the plasma membrane (PM) acts as a sensor and regulator of HSR through changes in its microdomain organization. PM microdomains such as lipid rafts, dynamic nanoscale assemblies enriched in cholesterol and sphingomyelin, and ...

    • Neuroinflammatory processes are augmented in mice overexpressing human heat-shock protein B1 following ethanol-induced brain injury 

      Dukay, Brigitta; Walter, Fruzsina; Vigh, Judit; Barabasi, Beata; Hajdu, Petra; Balassa, Tamas; Migh, Ede; Kincses, Andras; Hoyk, Zsofia; Szogi, Titanilla; Borbely, Emoke; Csoboz, Balint; Horvath, Peter; Fulop, Livia; Penke, Botond; Vigh, Laszlo; Deli, Maria; Santha, Mikos; Toth, Melinda (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-10)
      Background - Heat-shock protein B1 (HSPB1) is among the most well-known and versatile member of the evolutionarily conserved family of small heat-shock proteins. It has been implicated to serve a neuroprotective role against various neurological disorders via its modulatory activity on inflammation, yet its exact role in neuroinflammation is poorly understood. In order to shed light on the exact ...

    • The Small Heat Shock Protein, HSPB1, Interacts with and Modulates the Physical Structure of Membranes 

      Csoboz, Balint; Gombos, Imre; Kóta, Zoltán; Dukic, Barbara; Klement, Éva; Varga-Zsíros, Vanda; Lipinszki, Zoltán; Páli, Tibor; Vígh, László; Török, Zsolt (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-30)
      Small heat shock proteins (sHSPs) have been demonstrated to interact with lipids and modulate the physical state of membranes across species. Through these interactions, sHSPs contribute to the maintenance of membrane integrity. HSPB1 is a major sHSP in mammals, but its lipid interaction profile has so far been unexplored. In this study, we characterized the interaction between HSPB1 and phospholipids. ...