Blar i forfatter Artikler, rapporter og annet (medisinsk biologi) "Falquet, Mar"

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    • Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field 

      Moens, Ugo; Passerini, Sara; Falquet, Mar; Sveinbjørnsson, Baldur; Pietropaolo, Valeria (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-09)
      Protein phosphorylation and dephosphorylation are the most common post-translational modifications mediated by protein kinases and protein phosphatases, respectively. These reversible processes can modulate the function of the target protein, such as its activity, subcellular localization, stability, and interaction with other proteins. Phosphorylation of viral proteins plays an important role in ...

    • Regulation of Transcriptional Activity of Merkel Cell Polyomavirus Large T-Antigen by PKA-Mediated Phosphorylation 

      Falquet, Mar; Prezioso, Carla; Ludvigsen, Maria A.; Bruun, Jack-Ansgar; Passerini, Sara; Sveinbjørnsson, Baldur; Pietropaolo, Valeria; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-03)
      Merkel cell polyomavirus (MCPyV) is the major cause of Merkel cell carcinoma (MCC), an aggressive skin cancer. MCPyV large T-antigen (LTag) and small T-antigen (sTag) are the main oncoproteins involved in MCPyV-induced MCC. A hallmark of MCPyV-positive MCC cells is the expression of a C-terminal truncated LTag. Protein kinase A (PKA) plays a fundamental role in a variety of biological processes, ...