Blar i forfatter Artikler, rapporter og annet (medisinsk biologi) "Hald, Sigurd"

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    • Assessing PDL-1 and PD-1 in NoneSmall Cell Lung Cancer: A Novel Immunoscore Approach 

      Paulsen, Erna-Elise; Kilvær, Thomas Karsten; Rakaee, Mehrdad; Al-Saad, Samer; Hald, Sigurd; Andersen, Sigve; Richardsen, Elin; Ness, Nora; Busund, Lill-Tove; Bremnes, Roy M.; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-05)
      Novel immune biomarkers could complement the TNM classification for nonesmall cell cancer (NSCLC), improving the prognostic accuracy. The present study evaluated the prognostic significance of the immune checkpoint molecules programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1) in 536 patients with stage I to IIIA NSCLC using an Immunoscore approach. Independently, and in combination, ...

    • CD45RO+ Memory T Lymphocytes – a Candidate Marker for TNM-Immunoscore in Squamous Non-Small Cell Lung Cancer 

      Paulsen, Erna-Elise; Kilvær, Thomas Karsten; Rakaeekhanehkenari, Mehrdad; Johansen Maurseth, Ramona; Al-Saad, Samer; Hald, Sigurd; Al-Shibli, Khalid; Andersen, Sigve; Richardsen, Elin; Busund, Lill-Tove; Bremnes, Roy M.; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11)
      Tumor-infiltrating lymphocytes (TILs) are vital in limiting cancer progression and may supplement the TNM classification. CD45RO+ memory TILs show major prognostic impact in various malignancies but have not been extensively explored in non–small cell lung cancer (NSCLC). In this study, we aimed to evaluate their potential in a NSCLC TNM-Immunoscore. Tissue microarrays were constructed from tumor ...