Blar i forfatter Artikler, rapporter og annet (medisinsk biologi) "Jacomin, Anne-Claire"

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    • Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in Drosophila 

      Jacomin, Anne-Claire; Gohel, Raksha; Hussain, Zunoon; Varga, Agnes; Maruzs, Tamas; Eddison, Mark; Sica, Margaux; Jain, Ashish; Moffat, Kevin G.; Johansen, Terje; Jenny, Andreas; Juhasz, Gabor; Nezis, Ioannis (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-14)
      Hunger drives food-seeking behaviour and controls adaptation of organisms to nutrient availability and energy stores. Lipids constitute an essential source of energy in the cell that can be mobilised during fasting by autophagy. Selective degradation of proteins by autophagy is made possible essentially by the presence of LIR and KFERQ-like motifs. Using in silico screening of Drosophila ...

    • Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses 

      Tusco, Radu; Jacomin, Anne-Claire; Jain, Ashish; Penman, Bridget S.; Larsen, Kenneth Bowitz; Johansen, Terje; Nezis, Ioannis P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-02)
      Selective autophagy is a catabolic process with which cellular material is specifically targeted for degradation by lysosomes. The function of selective autophagic degradation of self-components in the regulation of innate immunity is still unclear. Here we show that Drosophila Kenny, the homolog of mammalian IKKγ, is a selective autophagy receptor that mediates the degradation of the IκB kinase ...

    • Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila 

      Jacomin, Anne-Claire; Petridi, Stavroula; Di Monaco, Marisa; Bhujabal, Zambarlal; Jain, Ashish; Mulakkal, Nitha C.; Palara, Anthimi; Powell, Emma L.; Chung, Bonita; Zampronio, Cleidiane; Jones, Alexandra; Cameron, Alexander; Johansen, Terje; Nezis, Ioannis P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-26)
      Autophagy is the degradation of cytoplasmic material through the lysosomal pathway. One of the most studied autophagy-related proteins is LC3. Despite growing evidence that LC3 is enriched in the nucleus, its nuclear role is poorly understood. Here, we show that <i>Drosophila</i> Atg8a protein, homologous to mammalian LC3, interacts with the transcription factor Sequoia in a LIR motif-dependent ...