Blar i forfatter Artikler, rapporter og annet (medisinsk biologi) "Nager, Mireia"

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    • FAK inhibition induces glioblastoma cell senescence-like state through p62 and p27 

      Alza, Lía; Nager, Mireia; Visa, Anna; Cantí, Carles; Herreros, Judit (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-27)
      Focal adhesion kinase (FAK) is a central component of focal adhesions that regulate cancer cell proliferation and migration. Here, we studied the effects of FAK inhibition in glioblastoma (GBM), a fast growing brain tumor that has a poor prognosis. Treating GBM cells with the FAK inhibitor PF-573228 induced a proliferative arrest and increased cell size. PF-573228 also reduced the growth of GBM ...