Hewitt, Graeme; Carroll, Bernadette; Sarallah, Rezazadeh; Correia-Melo, Clara; Ogrodnik, Mikolaj; Nelson, Glyn; Otten, Elsje G; Manni, Diego; Antrobus, Robin; Morgan, Brian A; von Zglinicki, Thomas; Jurk, Diana; Seluanov, Andrei; Gorbunova, Vera; Johansen, Terje; Passos, João F; Korolchuk, Viktor I (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-23)
SQSTM1/p62 (sequestosome 1) selectively targets polyubiquitinated proteins for degradation via
macroautophagy and the proteasome. Additionally, SQSTM1 shuttles between the cytoplasmic and nuclear
compartments, although its role in the nucleus is relatively unknown. Here, we report that SQSTM1
dynamically associates with DNA damage foci (DDF) and regulates DNA repair. Upon induction of DNA
damage ...