Blar i forfatter Artikler, rapporter og annet (medisinsk biologi) "Okoli, Arinze Stanley"

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    • CRISPR/Cas9—Advancing Orthopoxvirus Genome Editing for Vaccine and Vector Development 

      Okoli, Arinze Stanley; Okeke, malachy ifeanyi; Tryland, Morten; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-22)
      : The clustered regularly interspaced short palindromic repeat (CRISPR)/associated protein 9 (Cas9) technology is revolutionizing genome editing approaches. Its high efficiency, specificity, versatility, flexibility, simplicity and low cost have made the CRISPR/Cas9 system preferable to other guided site-specific nuclease-based systems such as TALENs (Transcription Activator-like Effector ...

    • Hazard Characterization of Modified Vaccinia Virus Ankara Vector: What Are the Knowledge Gaps? 

      Okeke, Malachy Ifeanyi; Okoli, Arinze Stanley; Diaz Canova, Diana Karina; Oludotun, Taiwo G.; Tryland, Morten; Bøhn, Thomas; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-29)
      Modified vaccinia virus Ankara (MVA) is the vector of choice for human and veterinary applications due to its strong safety profile and immunogenicity in vivo. The use of MVA and MVA-vectored vaccines against human and animal diseases must comply with regulatory requirements as they pertain to environmental risk assessment, particularly the characterization of potential adverse effects to humans, ...

    • Molecular characterization and phylogenetics of Fennoscandian cowpox virus isolates based on the p4c and atip genes 

      Okeke, Malachy Ifeanyi; Okoli, Arinze Stanley; Nilssen, Øivind; Moens, Ugo; Tryland, Morten; Bøhn, Thomas; Traavik, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      Background: Cowpox virus (CPXV), a rodent-borne Orthopoxvirus (OPV) that is indigenous to Eurasia can infect humans, cattle, felidae and other animals. Molecular characterization of CPXVs isolated from different geographic locations is important for the understanding of their biology, geographic distribution, classification and evolution. Our aim was to characterize CPXVs isolated from Fennoscandia ...