Blar i forfatter Artikler, rapporter og annet (medisinsk biologi) "Rahman, Fatema"

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    • Inhibition of bacterial and human zinc-metalloproteases by bisphosphonate- and catechol-containing compounds 

      Rahman, Fatema; Nguyen, Tra-Mi; Adekoya, Olayiwola; Campestre, Cristina; Tortorella, Paolo; Sylte, Ingebrigt; Winberg, Jan-Olof (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-23)
      Compounds containg catechol or bisphosphonate were tested as inhibitors of the zinc metalloproteases, thermolysin (TLN), pseudolysin (PLN) and aureolysin (ALN) which are bacterial virulence factors, and the human matrix metalloproteases MMP-9 and −14. Inhibition of virulence is a putative strategy in the development of antibacterial drugs, but the inhibitors should not interfere with human enzymes. ...

    • Zinc-Chelating Compounds as Inhibitors of Human and Bacterial Zinc Metalloproteases 

      Rahman, Fatema; Wushur, Imin; Malla, Nabin; Åstrand, Ove Alexander Høgmoen; Rongved, Pål; Winberg, Jan-Olof; Sylte, Ingebrigt (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-22)
      Inhibition of bacterial virulence is believed to be a new treatment option for bacterial infections. In the present study, we tested dipicolylamine (DPA), tripicolylamine (TPA), tris pyridine ethylene diamine (TPED), pyridine and thiophene derivatives as putative inhibitors of the bacterial virulence factors thermolysin (TLN), pseudolysin (PLN) and aureolysin (ALN) and the human zinc metalloproteases, ...