• Fibroblast growth factor 2 conjugated with monomethyl auristatin E inhibits tumor growth in a mouse model 

      Krzyscik, Mateusz Adam; Zakrzewska, Malgorzata; Sørensen, Vigdis; Øy, Geir Frode; Bruheim, Skjalg; Haugsten, Ellen Margrethe; Mælandsmo, Gunhild Mari; Wiedlocha, Antoni; Otlewski, Jacek (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-20)
      Worldwide, cancer is the second leading cause of death. Regardless of the continuous progress in medicine, we still do not have a fully effective anti-cancer therapy. Therefore, the search for new targeted anti-cancer drugs is still an unmet need. Here, we present novel protein–drug conjugates that inhibit tumor growth in a mouse model of human breast cancer. We developed conjugates based on fibroblast ...