Recent additions

  • Functional Domains of the Early Proteins and Experimental and Epidemiological Studies Suggest a Role for the Novel Human Polyomaviruses in Cancer 

    Moens, Ugo; Prezioso, Carla; Pietropaolo, Valeria (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-18)
    As their name indicates, polyomaviruses (PyVs) can induce tumors. Mouse PyV, hamster PyV and raccoon PyV have been shown to cause tumors in their natural host. During the last 30 years, 15 PyVs have been isolated from humans. From these, Merkel cell PyV is classified as a Group 2A carcinogenic pathogen (probably carcinogenic to humans), whereas BKPyV and JCPyV are class 2B (possibly carcinogenic ...
  • Oral health related quality of life in long-term survivors of head and neck cancer compared to a general population from the seventh Tromsø study 

    Andreassen, Renate Harriet; Jönsson, Birgitta; Hadler-Olsen, Elin Synnøve (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-30)
    Background: Both the incidence and survival rate of head and neck cancer (HNC) is increasing, making quality of life of HNC survivors an important issue.<p> <p>Methods: In this cross-sectional study we compared the oral health related quality of life (OHRQoL) of long-term HNC survivors to that of a general population cohort from the seventh survey of the Tromsø study with the Oral Impact on Daily ...
  • The Hematology of Tomorrow Is Here-Preclinical Models Are Not: Cell Therapy for Hematological Malignancies 

    Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-24)
    The purpose of this review is to present the current knowledge on the clinical use of several forms of cell therapy in hematological malignancies and the preclinical models available for their study. In the context of allogeneic hematopoietic stem cell transplants, mesenchymal stromal cells are pursued to help stem cell engraftment and expansion, and control graft versus host disease. We further ...
  • Exercise training combined with calanus oil supplementation improves the central cardiodynamic function in older women 

    Štěpán, Marek; Dad’ová, Klára; Matouš, Miloš; Krauzová, Eva; Sontáková, Lenka; Koc, Michal; Larsen, Terje; Kuda, Ondrej; Štich, Vladimír; Rossmeislová, Lenka; Šiklová, Michaela (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-29)
    The aim of this study was to investigate the possible beneficial effects of exercise training (ET) with omega-3/Calanus oil supplementation on cardiorespiratory and adiposity parameters in elderly women. Fifty-five women (BMI: 19–37 kg/m<sup>2</sup> , 62–80 years old) were recruited and randomly assigned to the 4 month intervention with ET and omega-3 supplementation (Calanus oil, ET-Calanus) ...
  • Novel chemical-physical autopsy investigation in sudden infant death and sudden intrauterine unexplained death syndromes 

    Gatti, Antonietta M; Ristic, Marko; Stanzani, Stefano; Lavezzi, Anna M (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-08)
    Aim: Verify the presence of inorganic nanoparticle entities in brain tissue samples from sudden infant death syndrome (SIDS)/sudden intrauterine unexplained death syndrome (SIUDS) cases. The presence of inorganic debris could be a cofactor that compromises proper brain tissue functionality. Materials & methods: A novel autopsy approach that consists of neuropathological analysis procedures ...
  • Blood Transcriptome Analysis of Septic Patients Reveals a Long Non-Coding Alu-RNA in the Complement C5a Receptor 1 Gene 

    Emblem, Åse; Knutsen, Erik; Jørgensen, Tor Erik; Fure, Hilde; Johansen, Steinar Daae; Brekke, Ole Lars; Mollnes, Tom Eirik; Karlsen, Bård Ove (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-29)
    Many severe inflammation conditions are complement-dependent with the complement component C5a-C5aR1 axis as an important driver. At the RNA level, the blood transcriptome undergoes programmed expression of coding and long non-coding RNAs to combat invading microorganisms. Understanding the expression of long non-coding RNAs containing Alu elements in inflammation is important for reconstructing ...
  • Bisphenol A replacement chemicals, BPF and BPS, induce protumorigenic changes in human mammary gland organoid morphology and proteome 

    Winkler, Juliane; Liu, Pengyuan; Phong, Kiet; Hinrichs, Johanna H.; Ataii, Nassim; Williams, Katherine; Hadler-Olsen, Elin Synnøve; Samson, Susan; Gartner, Zev J.; Fisher, Susan; Werb, Zena (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-09)
    Environmental chemicals such as bisphenol A (BPA) are thought to contribute to carcinogenesis through their endocrine-disrupting properties. Due to accumulating evidence about negative human health effects, BPA is being phased out, but in parallel, exposures to replacement chemicals such as bisphenol S (BPS) and bisphenol F (BPF) are increasing. Little is known about their biologic effects, but ...
  • Protocol for Isolation and Culture of Mouse Hepatocytes (HCs), Kupffer Cells (KCs), and Liver Sinusoidal Endothelial Cells (LSECs) in Analyses of Hepatic Drug Distribution 

    Elvevold, Kjetil; Kyrrestad, Ingelin; Smedsrød, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-25)
    Development of the new generation of drugs (e.g., oligo- and polynucleotides administered intravascularly either as free compounds or as nano-formulations) frequently encounters major challenges such as lack of control of targeting and/or delivery. Uncontrolled or unwanted clearance by the liver is a well-known and particularly important hurdle in this respect. Hence, reliable techniques are needed ...
  • Lulworthinone: In Vitro Mode of Action Investigation of an Antibacterial Dimeric Naphthopyrone Isolated from a Marine Fungus 

    Juskewitz, Eric; Mishchenko, Ekaterina; Dubey, Vishesh Kumar; Jenssen, Marte; Jakubec, Martin; Rainsford, Philip; Isaksson, Johan Mattias; Andersen, Jeanette Hammer; Ericson, Johanna U (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-21)
    Treatment options for infections caused by antimicrobial-resistant bacteria are rendered ineffective, and drug alternatives are needed—either from new chemical classes or drugs with new modes of action. Historically, natural products have been important contributors to drug discovery. In a recent study, the dimeric naphthopyrone lulworthinone produced by an obligate marine fungus in the family ...
  • Modulation of high affinity ATP-dependent cyclic nucleotide transporters by specific and non-specific cyclic nucleotide phosphodiesterase inhibitors 

    Aronsen, Lena; Ørvoll, Elin Peggy Hanne Øien; Lyså, Roy Andre; Ravna, Aina Westrheim; Sager, Georg (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-07)
    Intracellular cyclic nucleotides are eliminated by phosphodiesterases (PDEs) and by ATP Binding cassette transporters such as ABCC4 and ABCC5. PDE5 and ABCC5 have similar affinity for cGMP whereas ABCC5 has much higher affinity for cGMP compared with cAMP. Since the substrate (cGMP) is identical for these two eliminatory processes it is conceivable that various PDE inhibitors also modulate ...
  • Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in Drosophila 

    Jacomin, Anne-Claire; Gohel, Raksha; Hussain, Zunoon; Varga, Agnes; Maruzs, Tamas; Eddison, Mark; Sica, Margaux; Jain, Ashish; Moffat, Kevin G.; Johansen, Terje; Jenny, Andreas; Juhasz, Gabor; Nezis, Ioannis (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-14)
    Hunger drives food-seeking behaviour and controls adaptation of organisms to nutrient availability and energy stores. Lipids constitute an essential source of energy in the cell that can be mobilised during fasting by autophagy. Selective degradation of proteins by autophagy is made possible essentially by the presence of LIR and KFERQ-like motifs. Using in silico screening of Drosophila ...
  • The role of OAT2 (SLC22A7) in the cyclic nucleotide biokinetics of human erythrocytes 

    Sager, Georg; Smaglyukova, Natalia; Fuskevåg, Ole-Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-15)
  • Gene Expression, Function and Ischemia Tolerance in Male and Female Rat Hearts After Sub-Toxic Levels of Angiotensin II 

    Aljabri, Mohammad Belal; Lund, trine; Høper, Anje Christina; Andreasen, thomas vennØ; Al-Saad, Samer; Lindal, Sigurd; Ytrehus, Kirsti (Journal article; Tidsskriftartikkel; Peer reviewed, 2010-12-19)
    To examine the response to chronic high-dose angiotensin II (Ang II) and a proposed milder response in female hearts with respect to gene expression and ischemic injury. Female and male litter–matched rats were treated with 400 ng kg<sup>-1</sup> min<sup>-1</sup> Ang II for 14 days. Hearts were isolated, subjected to 30-min ischemia and 30-min reperfusion in combination with functional monitoring ...
  • Overexpression of NOX2 Exacerbates AngII‐Mediated Cardiac Dysfunction and Metabolic Remodelling 

    Hansen, Synne; Pedersen, Tina Myhre; Marin, Julie; Boardman, Neoma Tove; Shah, Ajay M.; Aasum, Ellen; Hafstad, Anne Dragøy (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-10)
    The present study aimed to examine the effects of low doses of angiotensin II (AngII) on cardiac function, myocardial substrate utilization, energetics, and mitochondrial function in C57Bl/6J mice and in a transgenic mouse model with cardiomyocyte specific upregulation of NOX2 (csNOX2 TG). Mice were treated with saline (sham), 50 or 400 ng/kg/min of AngII (AngII50 and AngII400) for two weeks. In ...
  • Content of endothelial progenitor cells in autologous stem cellgrafts predict survival after transplantation for multiplemyeloma 

    Blix, Egil Støre; Kildal, Anders Benjamin; Bertelsen, Eirin Listau; Waage, Anders; Myklebust, June; Kolstad, Arne; Husebekk, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-14)
    Multiple myeloma (MM) is considered an incurable B cell malignancy, although many patients can benefit from high-dose therapy with autologous stem cell transplantation (ASCT) as a first-line treatment. In nonHodgkin lymphoma (NHL), ASCT is usually performed after relapse with curative intent. Disease progression is often associated with increased angiogenesis, in which endothelial progenitor cells ...
  • Health and diseases of semi-domesticated reindeer in a climate change perspective 

    Tryland, Morten; Åhman, Birgitta; Sanchez Romano, Javier (Chapter; Bokkapittel, 2022-04-21)
    Climate change may affect reindeer herding and the health and disease of reindeer in several ways. One way of mitigating such changes is supplementary feeding, both in corrals and by bringing fodder to the animals on natural pastures. Feeding, when the right feed and feeding regime are used, may compensate for the loss of natural pastures and increase animal welfare. However, feeding may also cause ...
  • Ixodes ricinus and Borrelia prevalence at the Arctic Circle in Norway 

    Hvidsten, Dag; Stuen, Snorre; Jenkins, Andrew; Dienus, Olaf; Olsen, Renate Slind; Kristiansen, Bjørn-Erik; Mehl, Reidar Arne; Matussek, Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-11-18)
    The distribution limit of Ixodes ricinus ticks in northwestern Europe (Brønnøy, Norway, 1◦ south of the Arctic Circle), has been known since the 1930s. To reconfirm this finding and extend studies in the areas adjacent to the Arctic Circle (66◦33 N), ticks were collected from dogs and cats in 8 districts in northern Norway from 64◦56 N to 68◦48 N. We detected 549 I. ricinus, 244 (44%) of them ...
  • The interplay of matrix metalloproteinase-8, transforming growth factor-β1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma 

    Åström, Pirjo; Juurikka, Krista; Hadler-Olsen, Elin Synnøve; Svineng, Gunbjørg; Cervigne, Nilva K.; Coletta, Ricardo D.; Risteli, Juha; Kauppila, Joonas H.; Skarp, Sini; Kuttner, Samuel; Oteiza, Ana; Sutinen, Meeri; Salo, Tuula (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-03)
    Background: Matrix metalloproteinase-8 (MMP-8) has oncosuppressive properties in various cancers. We attempted to assess MMP-8 function in oral tongue squamous cell carcinoma (OTSCC).<p> <p>Methods: MMP-8 overexpressing OTSCC cells were used to study the effect of MMP-8 on proliferation, apoptosis, migration, invasion and gene and protein expression. Moreover, MMP-8 functions were assessed in the ...
  • The immunophilin Zonda controls regulated exocytosis in endocrine and exocrine tissues 

    de la Riva-Carrasco, Rocío; Perez-Pandolfo, Sebastián; Suárez Freire, Sofía; Romero, Nuria M.; Bhujabal, Zambarlal; Johansen, Terje; Wappner, Pablo; Melani, Mariana (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-18)
    Exocytosis is a fundamental process in physiology, that ensures communication between cells, organs and even organisms. Hormones, neuropeptides and antibodies, among other cargoes are packed in exocytic vesicles that need to reach and fuse with the plasma membrane to release their content to the extracellular milieu. Hundreds of proteins participate in this process and several others in its regulation. ...
  • ATG8 Family Proteins Act as Scaffolds for Assembly of the ULK Complex SEQUENCE REQUIREMENTS FOR LC3-INTERACTING REGION (LIR) MOTIFS 

    Alemu, Endalkachew Ashenafi; Lamark, Trond; Torgersen, Knut Martin; Birgisdottir, Åsa birna; Larsen, Kenneth Bowitz; Jain, Ashish; Olsvik, Hallvard Lauritz; Øvervatn, Aud Karin; Kirkin, Vladimir; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-10-05)
    Autophagy is a lysosome-dependent degradation system conserved among eukaryotes. The mammalian Atg1 homologues, Unc-51 like kinase (ULK) 1 and 2, are multifunctional proteins with roles in autophagy, neurite outgrowth, and vesicle transport. The mammalian ULK complex involved in autophagy consists of ULK1, ULK2, ATG13, FIP200, and ATG101. We have used pulldown and peptide array overlay assays to ...

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