Hepatic disposal of advanced glycation end products during maturation and aging
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This is the accepted manuscript version. Published version available at http://dx.doi.org/10.1016/j.exger.2013.03.005 (PDF)
Date
2013Type
Journal articleTidsskriftartikkel
Peer reviewed
Author
Svistounov, Dmitri; Oteiza, Ana; Zykova, Svetlana; Sørensen, Karen Kristine; McCourt, Peter Anthony; McLachlan, Andrew J; Mccuskey, Robert Scott; Smedsrød, BårdAbstract
Aging is characterized by progressive loss of metabolic and biochemical functions and accumulation of metabolic by-products, including advanced glycation end products (AGEs), which are observed in several pathological conditions. A number of waste macromolecules, including AGEs are taken up from the circulation by endocytosis mainly into liver sinusoidal endothelial cells (LSECs) and Kupffer cells (KCs). However, AGEs still accumulate in different tissues with aging, despite the presence of this clearance mechanism. The aim of the present study was to determine whether the efficiency of LSECs and KCs for disposal of AGEs changes through aging.
Publisher
ElsevierCitation
Experimental Gerontology 48(2013) nr. 6 s. 549-556Metadata
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