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dc.contributor.authorHooper, Stuart B.
dc.contributor.authorFouras, Andreas
dc.contributor.authorSiew, Melissa
dc.contributor.authorWallace, Megan
dc.contributor.authorKitchen, Marcus
dc.contributor.authorte Pas, Arjan B
dc.contributor.authorKlingenberg, Claus
dc.contributor.authorLewis, Robert
dc.contributor.authorDavis, Peter
dc.contributor.authorMorley, Colin J.
dc.contributor.authorSchmölzer, Georg M.
dc.date.accessioned2014-03-20T14:52:45Z
dc.date.available2014-03-20T14:52:45Z
dc.date.issued2013
dc.description.abstractAs neonatal resuscitation critically depends upon lung aeration at birth, knowledge of the progression of this process is required to guide ongoing care. We investigated whether expired CO2 (ECO2) levels indicate the degree of lung aeration immediately after birth in two animal models and in preterm infants. Lambs were delivered by caesarean section and ventilated from birth. In lambs, ECO2 levels were significantly (p,0.0001) related to tidal volumes and CO2 clearance/breath increased exponentially when tidal volumes were greater than 6 mL/kg. Preterm (28 days of gestation; term = 32 days) rabbits were also delivered by caesarean section and lung aeration was measured using phase contrast X-ray imaging. In rabbit kittens, ECO2 levels were closely related (p,0.001) to lung volumes at end-inflation and were first detected when ,7% of the distal lung regions were aerated. ECO2 levels in preterm infants at birth also correlated with tidal volumes. In each infant, ECO2 levels increased to .10 mmHg 28 (median) (21–36) seconds before the heart rate increased above 100 beats per minute. These data demonstrate that ECO2 levels can indicate the relative degree of lung aeration after birth and can be used to clinically assess ventilation in the immediate newborn period.en
dc.identifier.citationPLoS ONE 8(2013) nr. 8 s. e70895-en
dc.identifier.cristinIDFRIDAID 1066720
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0070895
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/6007
dc.identifier.urnURN:NBN:no-uit_munin_5698
dc.language.isoengen
dc.publisherPublic Library of Science (PLoS)en
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Pediatrics: 760en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Pediatri: 760en
dc.titleExpired CO2 Levels Indicate Degree of Lung Aeration at Birthen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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