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dc.contributor.authorHurler, Julia
dc.contributor.authorSørensen, Karen Kristine
dc.contributor.authorFallalero, Adyary
dc.contributor.authorVuorela, Pia
dc.contributor.authorSkalko-Basnet, Natasa
dc.date.accessioned2014-05-09T08:50:14Z
dc.date.available2014-05-09T08:50:14Z
dc.date.issued2013
dc.description.abstractPreviously, we have proposed mupirocin-in-liposomes-in-hydrogel delivery system as advanced delivery system with the potential in treatment of burns. In the current studies, we evaluated the system for its cytotoxicity, ability to prevent biofilm formation, act on the mature biofilms, and finally determined its potential as wound treatment in in vivo mice burn model.The system was found to be nontoxic against HaCaT cells, that is, keratinocytes. It was safe for use and exhibited antibiofilm activity against S. aureus biofilms, although the activity was more significant against planktonic bacteria and prior to biofilm formation than against mature biofilms as shown in the resazurin and the crystal violet assays. An in vivo mice burn model was used to evaluate the biological potential of the system and the healing of burns observed over 28 days.The in vivo data suggest that the delivery system enhances wound healing and is equally potent as the marketed product of mupirocin. Histological examination showed no difference in the quality of the healed scar tissue, whereas the healing time for the new delivery system was shorter as compared to the marketed product. Further animal studies and development of more sophisticated in vivo model are needed for complete evaluation.en
dc.identifier.citationBioMed Research International (2013), Article ID 498485en
dc.identifier.cristinIDFRIDAID 1071132
dc.identifier.doihttp://dx.doi.org/10.1155/2013/498485
dc.identifier.issn2314-6133
dc.identifier.urihttps://hdl.handle.net/10037/6228
dc.identifier.urnURN:NBN:no-uit_munin_5910
dc.language.isoengen
dc.publisherHindawi Publishing Corporationen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Mathematics and natural science: 400::Chemistry: 440::Pharmaceutical chemistry: 448en
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Kjemi: 440::Legemiddelkjemi: 448en
dc.titleLiposomes-in-Hydrogel Delivery System with Mupirocin: In Vitro Antibiofilm Studies and In Vivo Evaluation in Mice Burn Modelen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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