Browsing Artikler, rapporter og annet (klinisk medisin) by Author "Jamaly, Simin"

Now showing items 1-3 of 3

    • Elevated Plasma Levels of P‐Selectin Glycoprotein Ligand‐1 Positive Microvesicles in Patients with Unprovoked Venous Thromboembolism 

      Jamaly, Simin; Basavaraj, Manjunath Goolyam; Starikova, Irina; Olsen, Randi; Brækkan, Sigrid K.; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-31)
      Background<br> Microvesicles (MVs) express antigens from their parental cells and have a highly procoagulant surface. Animal studies suggest that P‐Selectin Glycoprotein Ligand‐1 positive (PSGL‐1+) MVs play a role in the pathogenesis of venous thromboembolism (VTE).<p> Objective<br> The aim of this study was to determine plasma levels, the cellular origin and the morphological characteristics ...

    • Impact of preanalytical conditions on plasma concentration and size distribution of extracellular vesicles using Nanoparticle Tracking Analysis 

      Jamaly, Simin; Ramberg, Cathrine; Olsen, Randi; Latysheva, Nadezhda; Webster, Paul; Sovershaev, Timofey; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-21)
      Optimal pre-analytical handling is essential for valid measurements of plasma concentration and size distribution of extracellular vesicles (EVs). We investigated the impact of plasma preparation, various anticoagulants (Citrate, EDTA, CTAD, Heparin), and fasting status on concentration and size distribution of EVs measured by Nanoparticle Tracking Analysis (NTA). Blood was drawn from 10 healthy ...

    • A modified clot-based assay to measure negatively charged procoagulant phospholipids 

      Ramberg, Cathrine; Jamaly, Simin; Latysheva, Nadezhda; Wilsgård, line; Sovershaev, Timofey; Snir, Omri; Hansen, Jesper (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-29)
      Growing evidence supports a role for extracellular vesicles (EVs) in haemostasis and thrombosis due to exposure of negatively charged procoagulant phospholipids (PPL). Current commercial PPL-dependent clotting assays use chemically phospholipid depleted plasma to measure PPL activity. The purpose of our study was to modify the PPL assay by substituting the chemically phospholipid depleted plasma ...