Blar i forfatter Artikler, rapporter og annet (klinisk medisin) "Janota, Jan"
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Analysis of Antibiotic Exposure and Early-Onset Neonatal Sepsis in Europe, North America, and Australia
Giannoni, Eric; Dimopoulou, Varvara; Klingenberg, Claus Andreas; Navér, Lars; Nordberg, Viveka; Berardi, Alberto; El Helou, Salhab; Fusch, Gerhard; Bliss, Joseph M.; Lehnick, Dirk; Guerina, Nicholas; Seliga-Siwecka, Joanna; Maton, Pierre; Lagae, Donatienne; Mari, Judit; Janota, Jan; Agyeman, Philipp K A; Pfister, Riccardo; Latorre, Giuseppe; Maffei, Gianfranco; Laforgia, Nicola; Mózes, Eniko; Størdal, Ketil; Strunk, Tobias; Stocker, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-23)<p><b> IMPORTANCE</b> Appropriate use of antibiotics is life-saving in neonatal early-onset sepsis (EOS), but overuse of antibiotics is associated with antimicrobial resistance and long-term adverse outcomes. Large international studies quantifying early-life antibiotic exposure along with EOS incidence are needed to provide a basis for future interventions aimed at safely reducing neonatal ... -
Less is more: Antibiotics at the beginning of life
Stocker, Martin; Klingenberg, Claus Andreas; Navér, Lars; Nordberg, Viveka; Berardi, Alberto; el Helou, Salhab; Fusch, Gerhard; Bliss, Joseph M.; Lehnick, Dirk; Dimopoulou, Varvara; Guerina, Nicholas; Seliga-Siwecka, Joanna; Maton, Pierre; Lagae, Donatienne; Mari, Judit; Janota, Jan; Agyeman, Philipp K. A.; Pfister, Riccardo; Latorre, Giuseppe; Maffei, Gianfranco; Laforgia, Nichola; Mózes, Enikő; Størdal, Ketil; Strunk, Tobias; Giannoni, Eric (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-27)Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance and perturbations of the developing microbiome. Early-life microbiome disruption increases the risks of developing chronic diseases later in life. Fear of missing evolving neonatal sepsis is the key driver for antibiotic overtreatment early in life. Bias (a systemic deviation towards overtreatment) and noise ... -
Neonatal sepsis: a systematic review of core outcomes from randomised clinical trials
Henry, Cían J.; Semova, Gergana; Barnes, Ellen; Cotter, Isabel; Devers, Tara; Rafaee, Aisyah; Slavescu, Andreea; Cathain, Niamh O.; McCollum, Danielle; Roche, Edna; Mockler, David; Allen, John; Meehan, Judith; Klingenberg, Claus Andreas; Latour, Jos M.; van den Hoogen, Agnes; Strunk, Tobias; Giannoni, Eric; Schlapbach, Luregn J.; Degtyareva, Marina; Plötz, Frans B.; de Boode, Willem P.; Naver, Lars; Wynn, James L.; Küster, Helmut; Janota, Jan; Keij, Fleur M.; Reiss, Irwin K. M.; Bliss, Joseph M.; Polin, Richard; Koenig, Joyce M.; Turner, Mark A.; Gale, Christopher; Molloy, Eleanor J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-07)BACKGROUND: The lack of a consensus definition of neonatal sepsis and a core outcome set (COS) proves a substantial impediment to research that influences policy and practice relevant to key stakeholders, patients and parents.<p> <p>METHODS: A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. ...