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norskArtikler, rapporter og annet (klinisk medisin): Recent submissions
Now showing items 1141-1160 of 1974
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Hva styrker verdigheten til kreftsyke kvinner som ønsker å dø hjemme?
(Journal article; Tidsskriftartikkel, 2019-05-15)Når pasienter ønsker å dø hjemme er det viktig at hjemmesykepleiere har god kompetanse i bruken av symptomlindrende legemidler. Hensikten med studien er å utvikle ny kunnskap om hjemmesykepleieres erfaringer med å bruke medikamentskrin i symptomlindrende omsorg for hjemmeboende pasienter i terminalfase. Vi presenterer faktorer som skaper trygghet og fremmer bruken av medikamentskrinet, i tillegg til ... -
Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-27)<i>Introduction</i> - Right ventricular (RV) myocardial dysfunction is a common feature in septic shock. It can worsen outcome, but the etiology is poorly understood. Pulmonary artery hypertension (PAH) plays a part in the pathogenesis of the right heart dysfunction in sepsis but its importance is unknown. In pigs, PAH in sepsis is substantial and the translational value of porcine sepsis models ... -
Tumor necrosis factor inhibitors are associated with reduced complement activation in spondylarthropathies: An observational study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-23)<i>Background</i> - The complement system is involved in pathogenesis of cardiovascular disease, and might play a role in accelerated atherogenesis in spondylarthropathies (SpA). Hence, we examined complement activation in SpA, and its relationship to antirheumatic treatment, inflammatory and cardiovascular markers. <p> <p><i>Methods</i> - From PSARA, a prospective observational study, we examined ... -
Telemonitoring and quality of life in patients after 12 months following a pacemaker implant: The Nordland study, a randomised trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-05)The purpose of this study was to analyse the health-related quality of life (HRQoL) of patients followed up using a remote device-monitoring system (TM) compared to patients followed up through standard outpatient visits (HM), 12 months after the implantation of a pacemaker. This was a trial design that used the EuroQol-5D Questionnaire and the Minnesota Living with Heart Failure Questionnaire (MLHF). ... -
Contribution of adverse events to death of hospitalised patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-13)<i>Background</i> - There is no standardised method to investigate death as a patient safety indicator and we need valid and reliable measurements to use adverse events contributing to death as a quality measure.<p> <p><i>Objective</i> - To investigate the contribution of severe adverse events to death in hospitalised patients and clarify methodological differences using the Global Trigger Tool ... -
Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration
(Journal article; Peer reviewed; Tidsskriftartikkel, 2018-04-12)<b>Aims</b><br> Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk.<br> <b>Methods and results</b><br> From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts ... -
Traumatic amputations caused by drone attacks in the local population in Gaza: a retrospective cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-14)<i>Background</i> - Little data exist to describe the use and medical consequences of drone strikes on civilian populations in war and conflict zones. Gaza is a landstrip within the Palestinian territories and the home of 2 million people. The median age in Gaza is 17·2 years and almost half of the population is below the age of 14 years. We studied the prevalence and severity of extremity amputation ... -
The role of Vitamin D binding protein, total and free 25-hydroxyvitamin D in diabetes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-19)Vitamin D is important for bone health, but may also have extra-skeletal effects. Vitamin D and its binding protein DBP have immunological effects and may therefore be important in the development of type 1 diabetes (T1DM), and low serum levels of 25-hydroxyvitamin D (25(OH)D) are associated with later development of type 2 diabetes (T2DM). However, it has so far been difficult to convincingly show ... -
The potential of specialized media in public health: Analysis of health-related content in sports newspapers
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-03)Sports-specialized newspapers are one of the print media with the highest number of readers in Spain. However, little is known about the health coverage in this type of print press. The aim of the study was to analyze any health-related material in sports newspaper coverage and describe the main characteristics. This is an observational and cross-sectional study, performed in relation to the three ... -
Differential prognostic impact of platelet-derived growth factor receptor Expression in NSCLC
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-15)Preclinical evidence suggests that stromal expression of platelet-derived growth factor receptors (PDGFRs) stimulates tumor development and diminishes intratumoral drug uptake. In non-small cell lung cancer (NSCLC), the clinical relevance of stromal PDGFR expression remains uncertain. Tumor specimens from 553 patients with primary operable stage I-IIIB NSCLC was obtained and tissue micro-arrays (TMA) ... -
Management of patients with metastatic prostate cancer (mPC) in a rural part of North Norway with a scattered population: does living near the department of oncology translate into a different pattern of care and survival?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-23)The goal of the Norwegian Ministry of Health and Care Services is to offer an equal health-care service with the same outcomes wherever people are living within the country. The aim of this study was to evaluate whether this was true for patients diagnosed with metastatic prostate cancer (mPC) and living in Nordland County, a region with a challenging geography and climate and having, several small ... -
Health-related quality of life after extracorporeal membrane oxygenation: a single centre's experience
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-07)<i>Aims</i>: The aims of this study were to evaluate health-related quality of life (HRQL) among patients treated with extracorpo-real membrane oxygenation (ECMO) in northern Norway over a period of 27years (1988–2015) and to identify variables related to HRQL.<p> <p><i>Methods and results</i>: A retrospective inquiry of the ECMO registry at the University Hospital of North Norway identified 74 ... -
The Role of Stroke as a Trigger for Incident Venous Thromboembolism: Results from a Population-based Case-Crossover Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-22)Stroke is associated with a short-term increased risk of subsequent venous thromboembolism (VTE). It is unclear to what extent this association is mediated by strokerelated complications that are potential triggers for VTE, such as immobilization and infection. We aimed to investigate the role of acute stroke as a trigger for incident VTE while taking other concomitant VTE triggers into account. ... -
MicroRNA 141 is associated to outcome and aggressive tumor characteristics in prostate cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-23)A large number of miRNAs influence key cellular processes involved in prostate tumorigenesis. Previous studies have demonstrated high expression of miRNAs in human prostate cancer (PC) tissues and cell lines. In previous microarray data, we found miR-141 to be upregulated and miR-145 to be downregulated in PC. In this large PC cohort (n = 535), we explored the prognostic role of miR-141 and miR-145 ... -
Crystallized but not soluble uric acid elicits pro-inflammatory response in short-term whole blood cultures from healthy men
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-19)Several epidemiological studies have pointed at serum uric acid (SUA) as an independent risk factor for mortality, diabetes, hypertension, cardiovascular and kidney disease; however, no clear pathogenic pathway is established. Uric acid (UA) crystals show pro-inflammatory properties and can thus create or contribute to the state of chronic low-grade inflammation, a widely accepted pathogenic mechanism ... -
Estimated 8-year cumulative incidence of diabetes mellitus among Sami and non-Sami inhabitants of Northern Norway- The SAMINOR Study
(Journal article; Peer reviewed, 2019-06-24)<b>Background</b><br> The aim of the study was to estimate and compare the 8-year cumulative incidence of diabetes mellitus (DM) among Sami and non-Sami inhabitants of rural districts in Northern Norway. <br><b>Methods</b><br> Longitudinal study based on linkage of two cross-sectional surveys, the SAMINOR 1 Survey (2003–2004) and the SAMINOR 2 Clinical Survey (2012–2014). Ten municipalities in rural ... -
The effect of trauma and alcohol on the relationship between level of cytokines and depression among patients entering psychiatric treatment
(Journal article; Peer reviewed, 2018-04-10)<b>Background</b><br> Depression is associated with immunological responses as reflected by altered levels of circulating cytokines. Alcohol use and trauma may modulate immune activity, and few studies have investigated these factors in depressed patients. We aimed to explore the association between circulating peripheral cytokine levels and degree of depressive symptoms, taking trauma and alcohol ... -
Validation of diagnostic utility of fasting plasma glucose and HbA1c in stable renal transplant recipients one year after transplantation
(Journal article; Peer reviewed, 2019-01-10)<b>Background</b><br> The use of HbA1c ≥6.5% for diagnosis of diabetes has been challenged for post-transplantation diabetes mellitus (PTDM) also known as new onset diabetes after transplantation (NODAT) due to a low sensitivity early after renal transplantation. PTDM diagnosed with an oral glucose tolerance test (OGTT) is highly predictable for long-term patient mortality. HbA1c was introduced for ... -
Screening for hepatitis C in a general adult population in a low-prevalence area: the Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-26)<i>Background - </i>Chronic hepatitis C virus (HCV) infection can progress to cirrhosis and end-stage liver disease in a substantial proportion of patients. The infection is frequently asymptomatic, leaving many infected individuals unaware of the diagnosis until complications occur. This advocates the screening of healthy individuals. The aim of this study was to estimate the prevalence of HCV ... -
Seasonal variations in objectively assessed physical activity among people with COPD in two Nordic countries and Australia: a cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-05)<i>Purpose</i>: Seasons and weather conditions might influence participation in physical activity and contribute to differences between countries. This study aimed at investigating whether there were differences in physical activity levels between Norwegian, Danish and Australian people with chronic obstructive pulmonary disease (COPD), and establishing if any variations in physical activity were ...
