Viser treff 1121-1140 av 1974

    • Low-grade impairments in cognitive and kidney function in a healthy middle-aged general population: a cross-sectional study 

      Småbrekke, Silje; Schirmer, Henrik; Melsom, Toralf; Solbu, Marit Dahl; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-14)
      <p><i>Background - </i>Although the relationship between manifest chronic kidney disease and reduced cognitive function is well established, limited data exists on GFR and cognitive function in the general population. Both the brain and kidneys have low-impedance vascular beds, rendering them susceptible to damage from pulsatile blood flow. An association between mildly reduced GFR and cognitive ...
    • A longitudinal study of cannabis use increasing the use of asthma medication in young Norwegian adults 

      Bramness, Jørgen Gustav; von Soest, Tilmann (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-26)
      <p><i>Background - </i>A small number of studies have shown that the use of cannabis increases the risk of bronchial asthma. There is, however, a paucity of longitudinal studies which are able to control for known risk factors of bronchial asthma. <p><i>Methods - </i>Survey data from a population-based longitudinal study encompassing 2602 young adults followed for 13 years were coupled with individual ...
    • Management of patients with brain metastases from non-small cell lung cancer and adverse prognostic features: multi-national radiation treatment recommendations are heterogeneous 

      Nieder, Carsten; Guckenberger, Matthias; Gaspar, Laurie E.; Rusthoven, Chad G.; De Ruysscher, Dirk; Sahgal, Arjun; Nguyen, Timothy; Grosu, Anca L.; Mehta, Minesh P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-15)
      <p><i>Background - </i>Different management options exist for patients with brain metastases from non-small cell lung cancer (NSCLC), patients whose treatment with whole brain radiotherapy (WBRT) has become more controversial over the last decade. It is not trivial to find the optimal balance of over- versus undertreatment in these patients. Several recent trials, including the randomized QUARTZ ...
    • A quality indicator set for use in rehabilitation team care of people with rheumatic and musculoskeletal diseases; development and pilot testing 

      Johansen, Inger; Klokkerud, Mari; Anke, Audny; Børke, Janne-Birgitte; Glott, Thomas; Hauglie, Uno; Høyem, Audhild; Klovning, Atle; Lande, Karin Anna; Larsen, Mona; Nordvik, Jan Egil; Wigers, Sigrid Hørven; Øyeflaten, Irene Larsen; Hagen, Kåre Birger; Kjeken, Ingvild (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-29)
      <p><i>Background - </i>Systems for monitoring effectiveness and quality of rehabilitation services across health care levels are needed. The purpose of this study was to develop and pilot test a quality indicator set for rehabilitation of rheumatic and musculoskeletal diseases. <p><i>Methods - </i>The set was developed according to the Rand/UCLA Appropriateness Method, which integrates evidence ...
    • Mortality, cause of death and risk factors in patients with alcohol use disorder alone or poly-substance use disorders: a 19-year prospective cohort study 

      Hjemsæter, Arne Jan; Bramness, Jørgen Gustav; Drake, Robert; Monsbakken, Bent Berntsen; Saltyte Benth, Jurate; Landheim, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
      <p><i>Background - </i>This study investigated cause of death, mortality rates and explored if baseline characteristics were associated with risk of death in patients with alcohol use disorder alone or poly-substance use disorders. <p><i>Methods - </i>This was a prospective, longitudinal study of patients followed for 19 years after entering specialized treatment for substance use disorders. At ...
    • Outcome of 881 total hip arthroplasties in 747 patients 21 years or younger: data from the Nordic Arthroplasty Register Association (NARA) 1995-2016 

      Halvorsen, Vera Baasland; Fenstad, Anne Marie; Engesæter, Lars B.; Nordsletten, Lars; Overgaard, Søren; Pedersen, Alma B.; Kärrholm, Johan; MOHADDES, MAZIAR; Eskelinen, Antti; Mäkelä, Keijo T.; Röhrl, Stephan Maximillian (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-15)
      <p><i>Background and purpose — </i>The literature is scarce on the outcome of the youngest patients with total hip arthroplasties (THAs). We analyzed register data, revision risk, and related factors in patients 21 years or younger with THAs in the Nordic Arthroplasty Register Association (NARA). <p><i>Patients and methods — </i>We included all THA patients 21 years or younger reported during 1995 ...
    • Predictors of early mortality after transcatheter aortic valve implantation 

      Kjønås, Didrik; Dahle, Gry; Schirmer, Henrik; Malm, Siri; Eidet, Jo; Aaberge, Lars; Steigen, Terje; Aakhus, Svend; Busund, Rolf; Rösner, Assami (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-23)
      <p><i>Objectives - </i>To investigate whether preoperative echocardiographic evaluation of ventricular function, especially right ventricular systolic and diastolic parameters including speckle-tracking analysis, could aid in the prediction of 30-day mortality after transcatheter aortic valve implantation (TAVI) in patients with aortic stenosis. <p><i>Methods - </i>This is a prospective observational ...
    • Relationship between level of CPR training, self-reported skills, and actual manikin test performance—an observational study 

      Lund-Kordahl, Inger; Mathiassen, Maria; Melau, Jørgen; Olasveengen, Theresa M.; Sunde, Kjetil; Fredriksen, Knut (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-10)
      <p><i>Background - </i>Quality of bystander cardiopulmonary resuscitation (CPR) skills may influence out of hospital cardiac arrest (OHCA) outcomes. We analyzed how the level of CPR training related to indicators of good CPR quality and also the relationship between self-reported skills and actual CPR performance. <p><i>Methods - </i>Two hundred thirty-seven persons trained in standardized BLS ...
    • Gender differences in association between uric acid and all-cause mortality in patients with chronic heart failure 

      Stubnova, Viera; Os, Ingrid; Høieggen, Aud; Solbu, Marit Dahl; Grundtvig, Morten; Westheim, Arne; Atar, Dan; Waldum-Grevbo, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-05)
      <p><i>Background - </i>Elevated serum uric acid (SUA) is associated with poor prognosis in patients with cardiovascular disease, yet it is still not decided whether the role of SUA is causal or only reflects an underlying disease. The purpose of the study was to investigate if SUA was an independent predictor of 5-year all-cause mortality in a propensity score matched cohort of chronic heart failure ...
    • Associations Between the Use of eHealth and Out-of-Hours Services in People With Type 1 Diabetes: Cross-Sectional Study 

      Hansen, Anne Helen; Claudi, Tor; Årsand, Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-21)
      <p><i>Background - </i>Despite the increasing prevalence of diabetes and the increasing use of eHealth, little is known about the association between provider-based health services and eHealth among people with diabetes. This is the second study in a project exploring the associations between the use of eHealth and the use of provider-based health services. <p><i>Objective - </i>The objective of ...
    • Novel GTF2I-PDGFRB and IKZF1-TYW1 fusions in pediatric leukemia with normal karyotype 

      Panagopoulos, Ioannis; Brunetti, Marta; Stoltenberg, Margrethe; Strandabø, Rønnaug; Staurseth, Julie; Andersen, Kristin; Kostolomov, Ilya; Hveem, Tarjei Sveinsgjerd; Lorenz, Susanne; Nystad, Tove Anita; Flægstad, Trond; Micci, Francesca; Heim, Sverre (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-29)
      <i>Background</i> - Many cases of acute lymphoblastic leukemia (ALL) carry visible acquired chromosomal changes of pathogenetic, diagnostic, and prognostic importance. Nevertheless, from one-fourth to half of newly diagnosed ALL patients have no visible chromosomal changes detectable by G-banding analysis at diagnosis. The introduction of powerful molecular methodologies has shown that many ...
    • Patients' experiences of remote communication after pacemaker implant: The NORDLAND study 

      Catalán-Matamoros, Daniel; Lopez-Villegas, Antonio; Lappegård, Knut Tore; Lopez-Liria, Remedios (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-20)
      <i>Background</i> - The concept of ‘patient experience’ has become central to how to improve healthcare. Remote communication with patients is today a frequent practice in healthcare services, showing similar outcomes to standard outpatient care while enabling cost reduction in both formal and informal care. The purpose of this study was to analyse the experiences of people with telemonitoring ...
    • D-Dimer Measured at Diagnosis of Venous Thromboembolism is Associated with Risk of Major Bleeding 

      Johnsen, Håkon Sandbukt; Hindberg, Kristian; Bjøri, Esben; Brodin, Ellen Elisabeth; Brækkan, Sigrid Kufaas; Morelli, Vania Maris; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-25)
      Identification of patients at risk of major bleeding is pivotal for optimal management of anticoagulant therapy in venous thromboembolism (VTE). Studies have suggested that D-dimer may predict major bleeding during anticoagulation; however, this is scarcely investigated in VTE patients. We aimed to investigate the role of D-dimer, measured at VTE diagnosis, as a predictive biomarker of major bleeding. ...
    • Not engaged in education, employment or training (NEET) in an Arctic sociocultural context: the NAAHS cohort study 

      Bania, Elisabeth Valmyr; Eckhoff, Christian; Kvernmo, Siv (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-23)
      <p><i>Objectives - </i>The purpose of the study is to explore the prevalence and predictors of not engaged in education, employment or training (NEET) status in a multicultural young adult population in Northern Norway. <p><i>Design and setting - </i>The longitudinal design link a selfreported survey (2003–2005) with an objective registry linkage follow-up 8–10 years later. <p><i>Participants - ...
    • Bone matrix levels of Dickkopf and sclerostin are positively correlated with bone mass and strength in postmenopausal osteoporosis 

      Ueland, Thor; Stilgren, Lis; Bollerslev, Jens (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-03)
      Wnt signaling plays a pivotal role in maintaining bone mass. Secreted pathway modulators such as sclerostin (SOST) and Dickkopfs (DKKs) may influence bone mass inhibiting the canonical Wnt pathway. We evaluated whether bone protein content of secreted Wnt antagonists is related to age, bone mass, and strength in postmenopausal osteoporosis. We measured cortical and trabecular bone contents of SOST ...
    • Adipokines and macrophage markers during pregnancy?Possible role for sCD163 in prediction and progression of gestational diabetes mellitus 

      Ueland, Thor; Michelsen, Annika; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens; Lekva, Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-13)
      <i>Aims</i> - The risk of gestational diabetes mellitus (GDM) is increased in overweight and obese women potentially involving secreted mediators from adipose tissue. Our main aim was to evaluate if circulating adipokines and monocyte/macrophage markers were dysregulated in GDM and the influence body mass and indices of glucose metabolism had on this association. We further explored if early detection ...
    • Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14 

      Skjeflo, Espen Waage; Christiansen, Dorte; Landsem, Anne; Stenvik, Jørgen; Woodruff, T. M.; Espevik, Terje; Nielsen, Erik Waage; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-15)
      <i>Background</i> - Sepsis is a dysregulated host response to infection. The aim of this study was to investigate the effects of complement- and CD14 inhibition on phagocytosis of live and dead Gram-negative and Gram-positive bacteria in human whole blood.<p> <p><i>Methods</i> - Lepirudin-anticoagulated blood was incubated with live or dead <i>E. coli</i> or <i>S. aureus</i> at 37 °C for 120 min ...
    • Plasma levels of mannose-binding lectin and future risk of venous thromboembolism 

      Liang, Robin Amanda; Høiland, Ina Isabella; Ueland, Thor; Aukrust, Pål; Snir, Omri; Hindberg, Kristian; Brækkan, Sigrid Kufaas; Garred, Peter; Mollnes, Tom Eirik; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-20)
      <i>Background</i> - Animal and observational studies have suggested a pathophysiological role for complement in venous thromboembolism (VTE), but the initiating mechanisms are unknown. Mannose‐binding lectin (MBL) bound to altered host cells leads to activation of the lectin complement pathway, and both high and low MBL levels have been implicated in the pathophysiology of cardiovascular ...
    • Changes in cytokines during treatment of elderly, hospitalized psychiatric patients - a naturalistic study 

      Bugge, Erlend; Wynn, Rolf; Mollnes, Tom Eirik; Reitan, Solveig Merete Klæbo; Lapid, Maria; Grønli, Ole Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-26)
      Immunological abnormalities have been demonstrated in several psychiatric disorders. Predominantly, studies have focused on younger adults, and research on elderly psychiatric in-patients is scant. In this naturalistic study, we investigated changes in cytokine levels during the treatment of diagnostically unselected elderly psychiatric in-patients, and whether these changes could be related to ...
    • Health Professionals' Experience with Patients Accessing Their Electronic Health Records: Results from an Online Survey 

      Johansen, Monika Alise; Kummervold, Per Egil; Sørensen, Tove; Zanaboni, Paolo (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
      The aim of this study was to investigate hospital professionals’ experience and attitude with patients accessing their own electronic health records. The study was conducted one year after service establishment. Data was collected through an online survey. In total, 457 replies were received. The results revealed a quarter of the administrative staff received feedback from patients or relatives ...