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norskArtikler, rapporter og annet (klinisk medisin): Nye registreringer
Viser treff 1101-1120 av 1974
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Participation in school and physical education in juvenile idiopathic arthritis in a Nordic long-term cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-15)<i>Background</i> - The aim of the study was to describe school attendance and participation in physical education in school among children with juvenile idiopathic arthritis (JIA).<p> <p><i>Methods</i> - Consecutive cases of JIA from defined geographical areas of Finland, Sweden and Norway with disease onset in 1997 to 2000 were followed for 8 years in a multi-center cohort study, aimed to be ... -
Moving psychological assessment out of the controlled laboratory setting: Practical challenges
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03)Behavioral assessment using smart devices affords novel methods, notably remote self-administration by the individuals themselves. However, this new approach requires navigating complex legal and technical terrain. Given the limited empirical data that currently exists, we provide and discuss anecdotes of the methodological, technical, legal, and cultural issues associated with an implementation in ... -
Head to head comparison of two commercial fecal calprotectin kits as predictor of Mayo endoscopic sub-score and mucosal TNF expression in ulcerative colitis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-02)<i>Background</i> - Fecal calprotectin is widely used to monitor disease activity in patients with inflammatory bowel disease. Multiple commercial kits exist, however, since the analyses are not standardized, these kits cannot be used interchangeably. We aimed to perform a technical evaluation of two kits (Calpro from Calprolab, Norway and Calprest from Eurospital, Italy) and perform a tuning for ... -
The Predictive Accuracy of the General Movement Assessment for Cerebral Palsy: A Prospective, Observational Study of High-Risk Infants in a Clinical Follow-Up Setting
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-25)Background: Early prediction of cerebral palsy (CP) using the General Movement Assessment (GMA) during the fidgety movements (FM) period has been recommended as standard of care in high-risk infants. The aim of this study was to determine the accuracy of GMA, alone or in combination with neonatal imaging, in predicting cerebral palsy (CP). Methods: Infants with increased risk of perinatal brain ... -
Seroprevalence of hepatitis E virus (HEV) in a general adult population in Northern Norway: the Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-22)Hepatitis E virus (HEV) is a major cause of acute viral hepatitis in many parts of the world but only a few cases have been diagnosed in Norway. To investigate the HEV exposure rate in a presumed low-risk area, we have conducted a population-based study of anti-HEV IgG seroprevalence in Northern Norway. A total of 1800 serum samples from 900 women and 900 men, age 40–79 years, were randomly selected ... -
Transcriptional profiling of ulcerative colitis in remission
(Journal article; Tidsskriftartikkel, 2019-01-25)<p><i>Background - </i>This study addresses whether existing transcriptional profiles can improve and support the current definition of UC in remission apart from the today existing endoscopic, histological and laboratory scoring systems. <p><i>Methods - </i>Mucosal biopsies from treatment-naïve UC patients (<i>n</i> = 14), healthy controls (<i>n</i> = 16), and UC patients in remission (<i>n</i> = ... -
Fibrosis Mediators in the Colonic Mucosa of Acute and Healed Ulcerative Colitis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-03)<i>OBJECTIVES</i>: A healed intestinal mucosa is the aim of therapy in acute ulcerative colitis (UC). Disruption of mucosal wound healing may lead to severe complications including intestinal fibrosis. This study examined mucosal gene expression in the healing process of acute UC with a special focus on known mediators of fibrosis.<p> <p><i>METHODS</i>: Endoscopic biopsies from patients with ... -
Grip strength in men and women aged 50–79 years is associated with non-vertebral osteoporotic fracture during 15 years follow-up: The Tromsø Study 1994–1995
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-25)<p><i>Summary - </i>In 50–79-year-olds who participated in the Tromsø Study (1994–1995), the risk of non-vertebral osteoporotic fractures during 15 years follow-up increased by 22% in men and 9% in women per 1 SD lower grip strength. The strongest association was observed in men aged 50–64 years. <p><i>Introduction - </i>We aimed to explore whether low grip strength was associated with increased ... -
High prevalence of vertebral fractures and low trabecular bone score in patients with fragility fractures: A cross-sectional sub-study of NoFRACT
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-08)<p><i>Purpose - </i>Norway has among the highest incidence rates of fractures in the world. Vertebral fracture assessment (VFA) and trabecular bone score (TBS) provide information about fracture risk, but their importance have not been studied in Norwegian patients with fragility fractures. The objectives of this study were to examine the clinical characteristics of a cohort of women and men with ... -
Alanine aminotransferase and body composition in obese men and women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-26)There is a known relationship between serum alanine aminotransferase (ALT) and obesity in humans, but the mechanism(s) are not clarified. This study investigated the associations between serum ALT and body composition in an overweight and obese population. The results are based on data from a previous randomized controlled trial treating obesity with vitamin D<sub>3</sub>. A sample of 448 overweight ... -
External validation of a prognostic score predicting overall survival for patients with brain metastases based on extracranial factors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-27)<i>Purpose</i>: The aim of our study was an external validation of the extracranial prognostic score predicting survival of patients with brain metastases receiving cranial irradiation on data from a single institution.<p> <p><i>Materials and methods</i>: A retrospective analysis of 524 patients with brain metastases treated with cranial radiotherapy in a single tertiary center was performed. ... -
Clinically Relevant Biomarker Discovery in High-Risk Recurrent Neuroblastoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-11)Neuroblastoma is a pediatric cancer of the developing sympathetic nervous system. High-risk neuroblastoma patients typically undergo an initial remission in response to treatment, followed by recurrence of aggressive tumors that have become refractory to further treatment. The need for biomarkers that can select patients not responding well to therapy in an early phase is therefore needed. In this ... -
Low expression levels of ATM may substitute for CHEK2/TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012-03-15)<i>Introduction</i>: Mutations affecting p53 or its upstream activator Chk2 are associated with resistance to DNA-damaging chemotherapy in breast cancer. ATM (Ataxia Telangiectasia Mutated protein) is the key activator of p53 and Chk2 in response to genotoxic stress. Here, we sought to evaluate ATM's potential role in resistance to chemotherapy.<p> <p><i>Methods</i>: We sequenced <i>ATM</i> and ... -
Postprandial changes in gene expression of cholesterol influx and efflux mediators after intake of SFA compared to n-6 PUFA in subjects with and without familial hypercholesterolemia: secondary outcomes of a randomized controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-13)The long-term cholesterol-lowering effect of replacing intake of SFA with PUFA is well established, but has not been fully explained mechanistically. We examined the postprandial response of meals with different fat quality on expression of lipid genes in peripheral blood mononuclear cells (PBMC) in subjects with and without familial hypercholesterolaemia (FH). Thirteen subjects with FH (who had ... -
The effect of white matter hyperintensities on regional brain volumes and white matter microstructure, a population-based study in HUNT
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-04)Even though age-related white matter hyperintensities (WMH) begin to emerge in middle age, their effect on brain micro- and macrostructure in this age group is not fully elucidated. We have examined how presence of WMH and load of WMH affect regional brain volumes and microstructure in a validated, representative general population sample of 873 individuals between 50 and 66 years. Presence of WMH ... -
Effect of genetically low 25-hydroxyvitamin D on mortality risk: Mendelian randomization analysis in 3 large European cohorts
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-02)The aim of this study was to determine if increased mortality associated with low levels of serum 25-hydroxyvitamin D (25(OH)D) reflects a causal relationship by using a Mendelian randomisation (MR) approach with genetic variants in the vitamin D synthesis pathway. Individual participant data from three European cohorts were harmonized with standardization of 25(OH)D according to the Vitamin D ... -
Pain-relieving effectiveness, quality of life and tolerability of repeated capsaicin 8% patch treatment of peripheral neuropathic pain in Scandinavian clinical practice
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-01)<p><i>Context - </i>Clinical trials have demonstrated the efficacy and safety of the capsaicin 8% patch in patients with peripheral neuropathic pain (PNP); however, few studies have assessed this treatment in a clinical practice. <p><i>Objective - </i>To determine whether treatment and re‐treatment with the capsaicin 8% patch reduce PNP intensity in clinical practice. <p><i>Methods - </i>Three ... -
A novel scale-space approach for multinormality testing and the k-sample problem in the high dimension low sample size scenario
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-22)Two classical multivariate statistical problems, testing of multivariate normality and the <i>k</i>-sample problem, are explored by a novel analysis on several resolutions simultaneously. The presented methods do not invert any estimated covariance matrix. Thereby, the methods work in the High Dimension Low Sample Size situation, i.e. when <i>n</i> ≤ <i>p</i>. The output, a significance map, is ... -
Bipolar radiofrequency neurotomy for spinal pain - A promising technique but still some steps to go
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-02) -
Fibroblast-Mediated Immunoregulation of Macrophage Function Is Maintained after Irradiation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-17)The abilities of cancer-associated fibroblasts (CAFs) to regulate immune responses in the context of radiotherapy remain largely unknown. This study was undertaken to determine whether ionizing radiation alters the CAF-mediated immunoregulatory effects on macrophages. CAFs were isolated from freshly-resected non-small cell lung cancer tumors, while monocyte-derived macrophages were prepared from ...
