Artikler, rapporter og annet (klinisk medisin): Recent submissions

Now showing items 41-60 of 1796

    • Global Transcriptome Analysis Reveals Distinct Phases of the Endothelial Response to TNF 

      Odeberg, Lynn Butler; Struck, Eike Christopher; Odeberg, Jacob Olof (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-29)
      The vascular endothelium acts as a dynamic interface between blood and tissue. TNF-α, a major regulator of inflammation, induces endothelial cell (EC) transcriptional changes, the overall response dynamics of which have not been fully elucidated. In the present study, we conducted an extended time-course analysis of the human EC response to TNF, from 30 min to 72 h. We identified regulated genes and ...

    • Dying at “home” - a qualitative study of end-of-life care in rural Northern Norway from the perspective of health care professionals 

      Ervik, Bente; Dønnem, Tom; Johansen, May Lill (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-05)
      Background - ‘Most patients want to die at home’ is a familiar statement in palliative care. The rate of home deaths is therefore often used as a success criterion. However, providing palliative care and enabling patients to die at home in rural and remote areas may be challenging due to limited health care resources and geographical factors. In this study we explored health care professionals’ ...

    • Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality. 

      Magnussen, Christina; Ojeda, Francisco M.; Leong, Darryl P.; Alegre-Diaz, Jesus; Amouyel, Philippe; Aviles-Santa, Larissa; De Bacquer, Dirk; Ballantyne, Christie M.; Bernabé-Ortiz, Antonio; Bobak, Martin; Brenner, Hermann; Carrillo-Larco, Rodrigo M.; De Lemos, James; Dobson, Annette; Dörr, Marcus; Donfrancesco, Chiara; Drygas, Wojciech; Dullaart, Robin P.; Engström, Gunnar; Ferrario, Marco M.; Ferrières, Jean; De Gaetano, Giovanni; Goldbourt, Uri; Gonzalez, Clicerio; Grassi, Guido; Hodge, Allison M.; Hveem, Kristian; Iacoviello, Licia; Ikram, M. Kamran; Irazola, Vilma; Jobe, Modou; Jousilahti, Pekka; Kaleebu, Pontiano; Kavousi, Maryam; Kee, Frank; Khalili, Davood; Koenig, Wolfgang; Kontsevaya, Anna; Kuulasmaa, Kari; Lackner, Karl J.; Leistner, David M.; Lind, Lars; Linneberg, Allan; Lorenz, Thiess; Lyngbakken, Magnus Nakrem; Malekzadeh, Reza; Malyutina, Sofia; Mathiesen, Ellisiv B.; Melander, Olle; Metspalu, Andres; Miranda, J. Jaime; Moitry, Marie; Mugisha, Joseph; Nalini, Mahdi; Nambi, Vijay; Ninomiya, Toshiharu; Oppermann, Karen; D'Orsi, Eleonora; Pająk, Andrzej; Palmieri, Luigi; Panagiotakos, Demosthenes; Perianayagam, Arokiasamy; Peters, Annette; Poustchi, Hossein; Prentice, Andrew M.; Prescott, Eva; Risérus, Ulf; Salomaa, Veikko; Sans, Susana; Sakata, Satoko; Schöttker, Ben; Schutte, Aletta E.; Sepanlou, Sadaf G.; Sharma, Sanjib Kumar; Shaw, Jonathan E.; Simons, Leon A.; Söderberg, Stefan; Tamosiunas, Abdonas; Thorand, Barbara; Tunstall-Pedoe, Hugh; Twerenbold, Raphael; Vanuzzo, Diego; Veronesi, Giovanni; Waibel, Julia; Wannamethee, S. Goya; Watanabe, Masafumi; Wild, Philipp S.; Yao, Yao; Zeng, Yi; Ziegler, Andreas; Blankenberg, Stefan (Journal article; Tidsskriftartikkel; Peer reviewed, 2023)
      BACKGROUND - Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.<p> <p>METHODS - We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic ...

    • Implementering av DBT i en rural kontekst. [Implementing DBT in a rural context]. Psykologtidskriftet. 

      Østmo, D.; Jørund, T.; Fors, Malin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-01)
      ABSTRACT Background and purpose: Dialectical behaviour therapy (DBT) is a widespread evidence-based method of treating emotionally unstable personality disorder, but the method has barely been studied in a rural context. The purpose of this study is to identify rural challenges for the four treatment channels of DBT, to pinpoint implicit urban starting points in DBT, and to suggest possible adaptations ...

    • The novel bacteriocin romsacin from Staphylococcus haemolyticus inhibits Gram-positive WHO priority pathogens 

      Wolden, Runa; Ovchinnikov, Kirill; Venter, Hermoine Jean; Oftedal, Thomas; Diep, Bao Dung; Cavanagh, Jorunn Pauline (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-31)
      Staphylococcus haemolyticus is an increasingly relevant nosocomial pathogen. The combination of multi-drug resistance and ability to form biofilms makes S. haemolyticus infections difficult to treat. Bacteriocins are ribosomally synthesized antimicrobial peptides produced by bacteria to inhibit growth of often closely related bacteria. Due to differences in the modes of action between bacteriocins ...

    • Performance of creatinine-based equations to estimate glomerular filtration rate in White and Black populations in Europe, Brazil and Africa 

      Delanaye, Pierre; Vidal-Petiot, Emmanuelle; Björk, Jonas; Ebert, Natalie; Eriksen, Bjørn Odvar; Dubourg, Laurence; Grubb, Anders; Hansson, Magnus; Littmann, Karin; Mariat, Christophe; Melsom, Toralf; Schaeffner, Elke; Sundin, Per-Ola; Bökenkamp, Arend; Berg, Ulla B.; Åsling-Monemi, Kajsa; Åkesson, Anna; Larsson, Anders; Cavalier, Etienne; Dalton, R Neil; Courbebaisse, Marie; Couzi, Lionel; Gaillard, Francois; Garrouste, Cyril; Jacquemont, Lola; Kamar, Nassim; Legendre, Christophe; Rostaing, Lionel; Stehlé, Thomas; Haymann, Jean-Philippe; Selistre, Luciano da Silva; Strogoff-de-Matos, Jorge P.; Bukabau, Justine B.; Sumaili, Ernest K.; Yayo, Eric; Monnet, Dagui; Nyman, Ulf; Pottel, Hans; Flamant, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-24)
      Background - A new Chronic Kidney Disease Epidemiology Collaboration equation without the race variable has been recently proposed (CKD-EPIAS). This equation has neither been validated outside USA nor compared with the new European Kidney Function Consortium (EKFC) and Lund-Malmö Revised (LMREV) equations, developed in European cohorts.<p> <p>Methods - Standardized creatinine and measured glomerular ...

    • C1 inhibitor deficiency enhances contact pathway–mediated activation of coagulation and venous thrombosis 

      Grover, Steven P.; Kawano, Tomohiro; Wan, Jun; Tanratana, Pansakorn; Polai, Zsofia; Shim, Young J.; Snir, Omri; Brækkan, Sigrid Kufaas; Dhrolia, Sophia; Kasthuri, Rohan R.; Bendapudi, Pavan K.; McCrae, Keith R.; Wolberg, Alisa S.; Hansen, John Bjarne; Farkas, Henriette; Mackman, Nigel (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-11)
      C1 inhibitor (C1INH) is a multifunctional serine protease inhibitor that functions as a major negative regulator of several biological pathways, including the contact pathway of blood coagulation. In humans, congenital C1INH deficiency results in a rare episodic bradykinin-mediated swelling disorder called hereditary angioedema (HAE). Patients with C1INH deficiency–associated HAE (C1INH-HAE) have ...

    • Prognostic factors and independent validation of a risk stratification model in octogenarian patients irradiated for brain metastases 

      Nieder, Carsten; Dalhaug, Astrid (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-25)
      Background/Aim: This study aimed at validation of a prognostic model, originally developed by Rades et al., in an age-restricted, particularly vulnerable subgroup of patients with brain metastases, because international variations in clinical practice and survival outcomes may impact on the performance of survival prediction tools. Patients and Methods: Retrospectively, data from a single institution ...

    • Independent validation of a risk stratification model predicting survival in elderly patients irradiated for bone metastases 

      Nieder, Carsten; Stanisavljevic, Luka; Mannsåker, Bård; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02)
      Background/Aim: Many patients with bone metastases receive palliative radiotherapy. However, treatment personalization tools are needed, due to heterogeneous survival. The aim of this study was to analyze the validity of the prognostic survival model, originally developed by Rades et al., because international variations in clinical practice and survival outcomes may impact on the performance of ...

    • The LabPS score: Inexpensive, Fast, and Site-agnostic Survival Prediction 

      Nieder, Carsten; Haukland, Ellinor Christin; Mannsåker, Bård; Dalhaug, Astrid (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04)
      Objectives: To provide a widely applicable, blood-biomarker-based and performance-status-based prognostic model, which predicts the survival of patients undergoing palliative non-brain radiotherapy. This model has already been examined in a cohort of patients treated for brain metastases and performed well.<p> <p>Methods: This was a retrospective single-institution analysis of 375 patients, ...

    • Patterns of Care and Survival in Cancer Patients with Brain Metastases Receiving Immune Checkpoint Inhibitors 

      Nieder, Carsten; Mannsåker, Bård; Stanisavljevic, Luka; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-15)
      Introduction: Immune checkpoint inhibitors (ICIs) have become a mainstay of treatment for different cancer types. The purpose of this study was to evaluate patterns of care and overall survival (OS) after diagnosis of brain metastases in patients managed with ICI as component of care. Methods: This was a retrospective cohort study. Fifty patients were included (34 with brain metastases at first ...

    • Impact of the von Willebrand factor-ADAMTS-13 axis on the risk of future venous thromboembolism 

      Edvardsen, Magnus; Hansen, Ellen-Sofie; Ueland, Thor; Aukrust, Pål; Brækkan, Sigrid Kufaas; Morelli, Vania Maris; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-01)
      Background - von Willebrand factor (VWF) and its cleaving protease, ADAMTS-13, form a pivotal axis that regulates hemostasis. However, the role of the VWF-ADAMTS-13 axis in the risk of future venous thromboembolism (VTE) is unknown.<p> <p>Objectives - To investigate whether plasma ADAMTS-13 levels and an imbalance with VWF levels, assessed as the VWF/ADAMTS-13 ratio, are associated with the risk ...

    • Complement factors B, D, C3bBbP and risk of future venous thromboembolism 

      Skjeflo, Espen Waage; Evensen, Line Holtet; Jensen, Søren Beck; Latysheva, Nadezhda; Michelsen, Annika Elisabet; Ueland, Thor; Brækkan, Sigrid Kufaas; Hindberg, Kristian Dalsbø; Snir, Omri; Mollnes, Tom Eirik; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-07)
      The complement system appears to be involved in the pathogenesis of venous thromboembolism (VTE).<p> <p>We investigated the association of complement factors (CF) B, D, and the alternative pathway convertase, C3bBbP, measured at inclusion, with the risk of future VTE in a nested case-control study; 380 VTE patients and 804 age- and sex-matched controls derived from the Tromsø study. Odds ratios ...

    • Forskjeller i mortalitet hos traumepasienter 

      Wisborg, Torben; Dehli, Trond; Eken, Torsten; Brattebø, Guttorm; Johnsen, Lars Gunnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-16)
      Mortaliteten blant norske traumepasienter i perioden 2015–18 var på linje med de beste resultatene fra andre land, men fortsatt fant vi regionale forskjeller og forskjeller mellom sykehusnivåer. Selv om resultatene er bra, kan vi bli bedre. Traumer er den viktigste dødsårsaken for personer under 44 år på verdensbasis, også i vår del av verden. Mortalitet er et internasjonalt anerkjent effektmål ...

    • Increased thromboinflammatory load in hereditary angioedema 

      Gramstad, Olav Rogde; Schjalm, Camilla; Mollnes, Tom Eirik; Nielsen, Erik Waage (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-10)
      C1 inhibitor (C1Inh) is a serine protease inhibitor involved in the kallikrein-kinin system, the complement system, the coagulation system, and the fibrinolytic system. In addition to the plasma leakage observed in hereditary angioedema (HAE), C1Inh deficiency may also affect these systems, which are important for thrombosis and inflammation. The aim of this study was to investigate the thromboinflammatory ...

    • Endometrial receptivity in women of advanced age: an underrated factor in infertility 

      Pathare, Amruta D.S.; Loid, Marina; Saare, Merli; Gidlöf, Sebastian Brusell; Esteki, Masoud Zamani; Acharya, Ganesh Prasad; Peters, Maire; Salumets, Andres (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-19)
      BACKGROUND Modern lifestyle has led to an increase in the age at conception. Advanced age is one of the critical risk factors for female-related infertility. It is well known that maternal age positively correlates with the deterioration of oocyte quality and chromosomal abnormalities in oocytes and embryos. The effect of age on endometrial function may be an equally important factor influencing ...

    • Liposomes - Human phagocytes interplay in whole blood: effect of liposome design 

      Giambelluca, Miriam Soledad; Markova, Elena; Louet, Claire; Steinkjer, Bjørg; Sundset, Rune; Skalko Basnet, Natasa; Hak, Sjoerd (Journal article; Tidsskriftartikkel, 2023-10-20)
      Nanomedicine holds immense potential for therapeutic manipulation of phagocytic immune cells. However, in vitro studies often fail to accurately translate to the complex in vivo environment. To address this gap, we employed an ex vivo human whole-blood assay to evaluate liposome interactions with immune cells. We systematically varied liposome size, PEG-surface densities and sphingomyelin and ...

    • A novel serum calprotectin (MRP8/14) particle-enhanced immuno-turbidimetric assay (sCAL turbo) helps to differentiate systemic juvenile idiopathic arthritis from other diseases in routine clinical laboratory settings 

      Foell, Dirk; Saers, Melanie; Park, Carolin; Brix, Ninna; Glerup, Mia; Kessel, Christoph; Wittkowski, Helmut; Hinze, Claas; Berntson, Lillemor; Fasth, Anders; Myrup, Charlotte; Nordal, Ellen Berit; Rygg, Marite; Hasle, Henrik; Albertsen, Birgitte Klug; Herlin, Troels; Holzinger, Dirk; Niederberger, Christian; Schlüter, Bernhard (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-25)
      Background Differential diagnosis in children with signs of unprovoked inflammation can be challenging. In particular, differentiating systemic juvenile idiopathic arthritis (SJIA) from other diagnoses is difficult. We have recently validated the complex of myeloid-related proteins 8/14 (MRP8/14, also known as S100A8/A9 complex or serum calprotectin) as a helpful biomarker supporting the diagnosis ...

    • The immunogenicity and safety of Group B Streptococcal maternal vaccines: A systematic review 

      Bjerkhaug, Aline Uhirwa; Ramalingham, Shouwmika; Mboizi, Robert; Le Doare, Kirsty; Klingenberg, Claus (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-09)
      Purpose: To systematically review immunogenicity and safety data of maternal group B streptococcal (GBS) vaccines in published clinical trials until July 2023.<p> <p>Methods: EMBASE, MEDLINE, Cochrane Library and clinicaltrial.gov. databases were searched for clinical studies that reported immunogenicity and/or safety of GBS vaccine in non-pregnant adults, pregnant women and infants between 1st ...

    • Change characteristics of health-related quality of life and its association with post-stroke fatigue at four-year follow-up 

      Garder Pedersen, Synne; Anke, Audny Gabriele Wagner; Løkholm, Mari Thoresen; Halvorsen, Marianne; Kirkevold, Marit; Heiberg, Guri Anita; Ørbo, Marte Christine; Friborg, Oddgeir (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-04)
      The long-term consequences of stroke may be highly individual and multifaceted. The question of how such individual differences may unfold and change beyond the first year after stroke may be of substantial clinical interest regarding which subgroups show more favourable and unfavourable rehabilitation trajectories. The current study explored functional trajectories from 1 to 4 years post-stroke ...