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dc.contributor.authorStabell, Niklas
dc.contributor.authorStubhaug, Audun
dc.contributor.authorFlægstad, Trond
dc.contributor.authorMayer, Emeran
dc.contributor.authorNaliboff, Bruce D
dc.contributor.authorNielsen, Christopher Sivert
dc.date.accessioned2014-11-07T13:57:31Z
dc.date.available2014-11-07T13:57:31Z
dc.date.issued2014-06-03
dc.description.abstractWidespread hyperalgesia is well documented among adult patients with Irritable Bowel Syndrome (IBS), but little is known about pain sensitivity among adolescents with IBS. We examined pain sensitivity in 961 adolescents from the general population (mean age 16.1 years), including pain threshold and tolerance measurements of heat (forearm) and pressure pain (fingernail and shoulder), and cold-pressor tolerance (hand). Adolescents with IBS symptoms (Rome III criteria) had lower heat pain thresholds compared to controls after adjustments for sex, co-morbid pain and psychological distress (mean difference = -0.8 oC; 95% CI = -1.6 to -0.04). Similar results were found for pressure pain threshold at the shoulder (mean difference = -46 kPa; 95% CI = -78 to -13) and fingernail (mean difference = -62 kPa; 95% CI = -109 to -15), and for an aggregate of all three threshold measures (z-score difference = -0.4; 95% CI = -0.6 to -0.2), though pressure pain threshold differences were non-significant after the final adjustments for psychological distress. No difference of pain tolerance was found between the IBS cases and controls. Our results indicate that adolescents in the general population with IBS symptoms, like adults, have widespread hyperalgesia.en
dc.descriptionThis article is part of Niklas Stabell's doctoral thesis, which is available in Munin at <a href=http://hdl.handle.net/10037/6798>http://hdl.handle.net/10037/6798</a>en
dc.identifier.citationJournal of Pain, Volume 15, Issue 9, September 2014, Pages 898–906en
dc.identifier.cristinIDFRIDAID 1148526
dc.identifier.doi10.1016/j.jpain.2014.05.007
dc.identifier.issn1526-5900
dc.identifier.urihttps://hdl.handle.net/10037/6806
dc.identifier.urnURN:NBN:no-uit_munin_6405
dc.language.isoengen
dc.publisherElsevieren
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en
dc.subjectWidespread hyperalgesiaen
dc.subjectirritable bowel syndromeen
dc.subjectcomorbidityen
dc.subjectquantitative pain sensitivity testingen
dc.subjectadolescentsen
dc.titleWidespread hyperalgesia in adolescents with symptoms of irritable bowel syndrome: results from a large population-based studyen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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