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dc.contributor.authorJøraholmen, May Wenche
dc.contributor.authorVanić, Željka
dc.contributor.authorTho, Ingunn
dc.contributor.authorŠkalko-Basnet, Nataša
dc.date.accessioned2015-02-26T10:22:45Z
dc.date.available2015-02-26T10:22:45Z
dc.date.issued2014
dc.description.abstractThe choice of drug therapy in pregnant patients suffering from vaginal infections is limited by the safety profile of the drug. Assuring the efficient topical therapy to avoid systemic absorption is considered the best therapy option. Chitosan-coated liposomes have been developed and optimized to assure localized therapy of clotrimazole. Chitosan was selected as mucoadhesive polymer both to prolong system's retention at the vaginal site and act on biofilms responsible for high recurrence of infections. Sonicated liposomes were coated with chitosan in three different concentrations, namely 0.1, 0.3 and 0.6% (w/v). Clotrimazole-containing (22 μg/mg lipid) chitosan-coated liposomes were in the size range of 100–200 nm. The <i>in vitro</i> release studies confirmed prolonged release of clotrimazole from both non-coated and chitosan-coated liposomes as compared to control. The <i>ex vivo</i> penetration experiments performed on the pregnant sheep vaginal tissue showed that coated liposomes assured increased clotrimazole tissue retention and reduced its penetration as compared to the control. Mucin studies revealed that the coating with lower chitosan concentration increased the system's mucoadhesive potential, as compared to coating with higher concentrations. These results provide a good platform for further <i>in vivo</i> animal studies on mucoadhesive liposomes destined to localized vaginal therapy.
dc.identifier.citationJøraholmen, M.W., Vanić, Ž., Tho, I. & Škalko-Basnet, N. (2014). Chitosan-coated liposomes for topical vaginal therapy: Assuring localized drug effect. <i>International Journal of Pharmaceutics, 472</i>(1-2), 94-101.en_US
dc.identifier.cristinIDFRIDAID 1138327
dc.identifier.doi10.1016/j.ijpharm.2014.06.016
dc.identifier.issn0378-5173
dc.identifier.urihttps://hdl.handle.net/10037/7243
dc.identifier.urnURN:NBN:no-uit_munin_6835
dc.language.isoengen_US
dc.publisherElsevier Scienceen_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Klinisk farmakologi: 739en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Clinical pharmacology: 739en_US
dc.titleChitosan-coated liposomes for topical vaginal therapy: Assuring localized drug effecten_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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