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dc.contributor.authorGrindstad, Thea
dc.contributor.authorAndersen, Sigve
dc.contributor.authorAl-Saad, Samer
dc.contributor.authorDønnem, Tom
dc.contributor.authorKiselev, Yury
dc.contributor.authorMelbø-Jørgensen, Christian
dc.contributor.authorSkjefstad, Kaja
dc.contributor.authorBusund, Lill-Tove
dc.contributor.authorBremnes, Roy M.
dc.contributor.authorRichardsen, Elin
dc.date.accessioned2016-03-04T11:19:31Z
dc.date.available2016-03-04T11:19:31Z
dc.date.issued2015-02-27
dc.description.abstractBackground Prostate cancer is a highly heterogeneous disease and one of the leading causes of mortality in developed countries. Specific prognostic and predictive markers for prostate cancer patients are still lacking. A causal relationship between androgens and the development of prostate cancer is generally considered biologically plausible, but androgens are not the sole effector in the complexity of prostate carcinogenesis. The aim of this study was to evaluate the prognostic significance of progesterone receptor in tumor tissue of T1-3N0 prostate cancer patients undergoing prostatectomy. <p>Methods Tissue microarrays from 535 patients with prostate cancer were constructed. Duplicate cores of tumor cells and tumor stromal tissue from each resected specimen were extracted. Immunohistochemistry was used to evaluate the in-situ expression of progesterone receptor. <p>Results In univariate analyses, high tumor cell density (p = 0.006) and high tumor stromal cell density level (p = 0.045) of progesterone receptor were both significantly associated with tumor progression and clinical failure. In multivariate analysis, progesterone receptor expression in tumor cells was an independent negative prognostic factor for clinical failure (HR: 2.5, 95% CI: 1.2–5.2, p = 0.012). <p>Conclusion High progesterone receptor density in tumor cells of the prostate cancer tumor is an independent negative prognostic factor for clinical failure.en_US
dc.identifier.citationPLoS ONE 2015, 10:e0116691(2)en_US
dc.identifier.issn1932-6203
dc.identifier.otherFRIDAID 1232737
dc.identifier.other10.1371/journal.pone.0116691
dc.identifier.urihttp://hdl.handle.net/10037/8690
dc.identifier.urnURN:NBN:no-uit_munin_8228
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.titleHigh progesterone receptor expression in prostate cancer is associated with clinical failureen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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