Show simple item record

dc.contributor.authorKumari, Jaya
dc.contributor.authorZhang, Zuobing
dc.contributor.authorSwain, Trilochan
dc.contributor.authorChi, Heng
dc.contributor.authorNiu, Cuijuan
dc.contributor.authorBøgwald, Jarl
dc.contributor.authorDalmo, Roy Ambli
dc.date.accessioned2016-03-08T12:58:19Z
dc.date.available2016-03-08T12:58:19Z
dc.date.issued2015-07-06
dc.description.abstractThe T-box transcription factor T-bet is expressed in a number of hematopoietic cell types in mammals and plays an essential role in the lineage determination of Th1 T-helper cells and is considered as an essential feature for both innate and adaptive immune responses in higher vertebrates. In the present study, we have identified and characterized the full-length Atlantic salmon T-bet cDNA (3502 bp). The putative primary structure of the polypeptide deduced from the cDNA sequence contained 612 aa, which possessed a T-box DNA binding domain. Phylogenetic study and gene synteny revealed it is as a homolog to mammalian T-bet. Quantitative PCR analysis of different tissues in healthy fish showed that salmon T-bet gene was highly expressed in spleen, followed by head kidney, and was expressed in intestine, skin, and liver at lower levels. Moreover, the time-dependent expression profile of T-bet, interferon gamma (IFNγ), interleukin-22 (IL-22), and natural killer enhancement factor in mucosal tissues during water-borne infection with live Aeromonas salmonicida, indicated the involvement of T-bet in mucosal immune response in Atlantic salmon.en_US
dc.descriptionPublished version. Also available at <a href= http://dx.doi.org/10.3389/fimmu.2015.00345> http://dx.doi.org/10.3389/fimmu.2015.00345</a>en_US
dc.identifier.citationFrontiers in Immunology 2015, 6:345en_US
dc.identifier.cristinIDFRIDAID 1257585
dc.identifier.doi10.3389/fimmu.2015.00345
dc.identifier.issn1664-3224
dc.identifier.urihttps://hdl.handle.net/10037/8763
dc.identifier.urnURN:NBN:no-uit_munin_8325
dc.language.isoengen_US
dc.publisherFrontiersen_US
dc.relation.projectIDNorges forskningsråd: 183204
dc.rights.accessRightsopenAccess
dc.subjectVDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920::Fiskehelse: 923en_US
dc.subjectVDP::Agriculture and fishery disciplines: 900::Fisheries science: 920::Fish health: 923en_US
dc.subjectAtlantic salmonen_US
dc.subjectT-beten_US
dc.subjectA. salmonicidaen_US
dc.subjectgene expressionen_US
dc.subjectmucosal immunityen_US
dc.titleTranscription factor T-bet in Atlantic salmon: characterization and gene expression in mucosal tissues during Aeromonas salmonicida infectionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record