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dc.contributor.authorStorhaug, Hilde-Merete
dc.contributor.authorToft, Ingrid
dc.contributor.authorNorvik, Jon Viljar
dc.contributor.authorJenssen, Trond Geir
dc.contributor.authorEriksen, Bjørn Odvar
dc.contributor.authorMelsom, Toralf
dc.contributor.authorLøchen, Maja-Lisa
dc.contributor.authorSolbu, Marit Dahl
dc.date.accessioned2016-03-10T11:33:02Z
dc.date.available2016-03-10T11:33:02Z
dc.date.issued2015-12-11
dc.description.abstractBackground: The role of uric acid in development of renal dysfunction (RD) remains controversial. Earlier studies have reported inconsistent results, possibly because of their varying ability to adjust for confounding. The impact of longitudinal change in uric acid on renal outcome has not been assessed previously. We aimed to study the impact of change in serum uric acid (SUA) as well as baseline SUA on the development of RD. <p>Methods: In a prospective cohort study, we assessed the associations between change in SUA during follow-up, baseline SUA and RD (defined as albumin-creatinine-ratio (ACR) ≥1.13 mg albumin/mmol creatinine and/or eGFR < 60 ml/min/1.73 m2) in a large cohort from a general population participating in the Tromsø Study (n = 2637). Participants were stratified according to tertiles of change in SUA between baseline (1994/95) and follow-up 13 years later. (upper tertile: SUA increasing group, two lower tertiles: SUA non-increasing group). Logistic regression analysis was applied with RD and each component of RD after 7 and 13 years as the dependent variables. Adjustments were made for baseline eGFR, cardiovascular risk factors, and the use of antihypertensive drugs including diuretics. <p>Results: After excluding participants with RD at baseline, SUA increasers, compared to SUA non-increasers, had a doubled risk of RD after 7 years (odds ratio 2.00, (95 % CI 1.45, 2.75)). Odds ratio for RD in SUA increasers after 13 years was 2.18 (95 % CI 1.71, 2.79). The risk of developing ACR ≥1.13 mg/mmol alone was not significantly increased after 7 years (odds ratio 1.30 (95 % CI 0.90, 1.89), but after 13 years (odds ratio 1.43 (95 % CI 1.09, 1.86)). An increase in baseline SUA of 59 μmol/L (1 mg/dL) gave an odds ratio for RD after 13 years of 1.16 (95 % CI 1.04, 1.29). <p>Conclusion: An increase in SUA during follow-up was associated with an increased risk of developing RD after 7 and 13 years.en_US
dc.descriptionPublished version, also available at <a href=http://dx.doi.org/10.1186/s12882-015-0207-1>http://dx.doi.org/10.1186/s12882-015-0207-1</a>en_US
dc.identifier.citationBMC Nephrology (2015) 16:210en_US
dc.identifier.cristinIDFRIDAID 1310718
dc.identifier.doi10.1186/s12882-015-0207-1
dc.identifier.issn1471-2369
dc.identifier.urihttps://hdl.handle.net/10037/8846
dc.identifier.urnURN:NBN:no-uit_munin_8421
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi, urologi: 772en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Nephrology, urology: 772en_US
dc.subjectSerum uric aciden_US
dc.subjectRenal dysfunctionen_US
dc.subjectEpidemiologyen_US
dc.subjectAlbumin-creatinine ratioen_US
dc.titleUric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of follow-up: The Tromsø Studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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