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dc.contributor.authorLappegård, Jostein
dc.contributor.authorEllingsen, Trygve
dc.contributor.authorVik, Anders
dc.contributor.authorSkjelbakken, Tove
dc.contributor.authorBrox, Jan
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorJohnsen, Stein Harald
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorHansen, John-Bjarne
dc.date.accessioned2016-03-22T07:34:03Z
dc.date.available2016-03-22T07:34:03Z
dc.date.issued2015-01-29
dc.description.abstractRed cell distribution width (RDW), a measure of the size variability of circulating erythrocytes, is associated with cardiovascular morbidity and mortality. We aimed to investigate whether RDW was associated with progression of atherosclerotic plaques in subjects recruited from the general population. Baseline characteristics, including RDW, were collected from 4677 participants in the fourth survey of the Tromsø Study conducted in 1994/95. Prevalence of carotid plaques and total plaque area (TPA) were assessed by ultrasonographic imaging at baseline and after seven years of follow-up. Generalised linear models were used to analyse change in TPA across tertiles of RDW. Change in TPA was significantly higher across tertiles of RDW in crude analysis and in multivariable analysis adjusted for cardiovascular risk factors. The mean change in TPA increased from 5.6 mm² (4.9–6.4) in tertile 1 (RDW ≤ 12.6 %) to 6.7 mm² (5.9–7.6) in tertile 3 (RDW ≥ 13.3) in multivariable analysis adjusted for body mass index, total cholesterol, HDL cholesterol, systolic blood pressure, self-reported diabetes, smoking status, platelet count, white blood cell count, and hs-CRP levels (p for trend 0.003). A 1 % increase in RDW was associated with 0.6 mm² (0.1–1.2) increase in TPA in multivariable analysis (p=0.03). RDW was associated with progression of atherosclerosis after adjustments for traditional atherosclerotic risk factors. Our findings suggest that the link between RDW and cardiovascular morbidity and mortality may be explained by atherosclerosis.en_US
dc.descriptionAccepted manuscript version. This article is not an exact copy of the original published article in Thrombosis and Haemostasis. The definitive publisher-authenticated version of "Red cell distribution width and carotid atherosclerosis progression: The Tromsø study" is available online at: <a href=http://doi.org/10.1160/TH14-07-0606>http://doi.org/10.1160/TH14-07-0606</a>.en_US
dc.identifier.citationThrombosis and Haemostasis 2015, 113(3):649-654en_US
dc.identifier.cristinIDFRIDAID 1193782
dc.identifier.doi10.1160/TH14-07-0606
dc.identifier.issn0340-6245
dc.identifier.urihttps://hdl.handle.net/10037/9054
dc.identifier.urnURN:NBN:no-uit_munin_8643
dc.language.isoengen_US
dc.publisherSchattaueren_US
dc.rights.accessRightsopenAccess
dc.subjectAtherosclerosisen_US
dc.subjectCardiovascular Diseaseen_US
dc.subjectEpidemiologyen_US
dc.subjectcohort studiesen_US
dc.subjecterythrocyte indicesen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775en_US
dc.titleRed cell distribution width and carotid atherosclerosis progression: The Tromsø studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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