Viser treff 1-20 av 13945

    • Rhodium-Catalyzed Hydrocarboxylation: Mechanistic Analysis Reveals Unusual Transition State for Carbon–Carbon Bond Formation 

      Pavlovic, Ljiljana; Vaitla, Janakiram; Bayer, Annette; Hopmann, Kathrin Helen (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-12)
      The mechanism of rhodium-COD-catalyzed hydrocarboxylation of styrene derivatives and α,β-unsaturated carbonyl compounds with CO<sub>2</sub> has been investigated using density functional theory (PBE-D2/IEFPCM). The calculations support a catalytic cycle as originally proposed by Mikami and co-workers including β-hydride elimination, insertion of the unsaturated substrate into a rhodium–hydride bond, ...
    • Mutational analysis of the pro-peptide of a marine intracellular subtilisin protease supports its role in inhibition 

      Bjerga, Gro Elin Kjæreng; Larsen, Øivind; ARSIN, Hasan; Williamson, Adele Kim; Garcia-Moyano, Antonio; Leiros, Ingar; Puntervoll, Pål (Journal article; Tidsskriftartikkel; Preprint; Manuskript, 2018-06-16)
      Intracellular subtilisin proteases (ISPs) have important roles in protein processing during the stationary phase in bacteria. Their unregulated protein degrading activity may have adverse effects inside a cell, but little is known about their regulatory mechanism. Until now, ISPs have mostly been described from <i>Bacillus</i> species, with structural data from a single homolog. Here, we study a ...
    • Systematic review of clinical and patient-reported outcomes following oral rehabilitation on dental implants with a tapered compared to a non-tapered implant design 

      Jokstad, Asbjørn; Ganeles, Jeffrey (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-17)
      <p><i>Background</i>: Dental implants are available in different shapes.</p> <p><i>Aims</i>: This systematic review aims to address whether tapered compared to non‐tapered implants demonstrate similar clinical and patient‐reported outcomes. The review follows the preferred reporting items for systematic reviews and meta‐analyses (PRISMA) format.</p> <p><i>Materials & Methods</i>: We searched ...
    • Local land use associated with socio-economic development in six arctic regions 

      Ehrich, Dorothee; Thuestad, Alma Elizabeth; Tømmervik, Hans; Fauchald, Per; Hausner, Vera Helene (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-04)
      The socioeconomic causes of land use change are complex. They are highly context dependent, but most often studied through case studies. Here, we use a quasi-experimental paired block design to investigate whether better access to wage income leads to more visible land use around 28 settlements in six regions of the circumpolar Arctic. We mapped visible land use on high-resolution satellite images ...
    • Drug permeability profiling using cell-free permeation tools: Overview and applications 

      Berben, Philippe; Bauer-Brandl, Annette; Brandl, Martin; Faller, Bernard; Flaten, Gøril Eide; Jacobsen, Ann-Cathrine; Brouwers, Joachim; Augustijns, Patrick (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-13)
      Cell-free permeation systems are gaining interest in drug discovery and development as tools to obtain a reliable prediction of passive intestinal absorption without the disadvantages associated with cell- or tissue-based permeability profiling. Depending on the composition of the barrier, cell-free permeation systems are classified into two classes including (i) biomimetic barriers which are ...
    • Intersecting Frames of Legibility in Conversion de Piritu (1690): A Remodeling of Paratexts in the Digital Setting 

      Sarion, Roxana Mihaela (Peer reviewed; Chapter; Bokkapittel, 2018-09-01)
      In this chapter Roxana Sarion examines the understudied Spanish colonial missionary text Conversion de Piritu (1690) by Matías Ruiz Blanco to demonstrate how it has been able to convey different cultural messages over time due to its changing material and visual forms, which becomes particularly prominent in the digital age. The change from the printed format to the digital adds new cultural dimensions ...
    • The independent and joint associations of physical activity and body mass index with myocardial infarction: The Tromsø Study 

      Renninger, Marius; Løchen, Maja-Lisa; Ekelund, Ulf; Hopstock, Laila Arnesdatter; Jørgensen, Lone; Mathiesen, Ellisiv B.; Njølstad, Inger; Schirmer, Henrik; Wilsgaard, Tom; Morseth, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-13)
      Physical activity and overweight are associated with myocardial infarction (MI). However, their joint association with MI remains unclear. Our objective was to examine the independent and joint association between leisuretime physical activity (LTPA), body mass index (BMI) and MI. This prospective cohort study included 16,572 men and women (47.5% women) aged 20–54 years who took part in the second ...
    • Measuring impact through experimental design in entrepreneurship education: A literature review and research agenda 

      Longva, Kjersti Kjos; Foss, Lene (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-16)
      True experimental design and quasi-experimental design are considered to be rigorous research designs appropriate for assessing the impact of pedagogical interventions. This study explores the extent and application of experimental design in impact research on entrepreneurship education (EE) based on a systematic literature review. The findings reveal a substantial lack of methodologically rigorous ...
    • Japanese tourists’ relatedness and connectedness with nature 

      Prebensen, Nina Katrine; Lee, Young-Sook; Kim, Hyelin Lina (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-15)
      Nature-based tourism continues to gain importance globally. Research on sustainability claims that disconnection between nature and humanity may contribute to the environmental problems that we face in the 21st century. It is, thus, quintessential to better understand the underlying variables for sustainable behaviour in a tourism context. Research suggests scales on nature relatedness (NRS) and ...
    • Cordilleran ice-sheet growth fueled primary productivity in the Gulf of Alaska, northeast Pacific Ocean 

      Müller, Juliane; Romero, Oscar; Cowan, Ellen A.; McClymont, Erin L.; Forwick, Matthias; Asahi, Hirofumi; März, Christian; Moy, Christopher M.; Suto, Itsuki; Mix, Alan; Stoner, Joseph (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-15)
      Fertilization of the ocean by eolian dust and icebergs is an effective mechanism to enhance primary productivity. In particular, high-nutrient, low-chlorophyll (HNLC) areas where phytoplankton growth is critically iron-limited, such as the subarctic Pacific Ocean and the Southern Ocean, are proposed to respond to increases in bioavailable Fe supply with enhanced phytoplankton productivity and carbon ...
    • Levonorgestrel-releasing intrauterine system use is associated with a decreased risk of ovarian and endometrial cancer, without increased risk of breast cancer. Results from the NOWAC Study 

      Jareid, Mie; Thalabard, Jean-Christophe; Aarflot, Morten; Bøvelstad, Hege Marie; Lund, Eiliv; Braaten, Tonje (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-02)
      <p><i>Objective</i>: Women with ovarian cancer have poor survival rates, which have proven difficult to improve; therefore primary prevention is important. The levonorgestrel-releasing intrauterine system (LNG-IUS) prevents endometrial cancer, and recent studies suggested that it may also prevent ovarian cancer, but with a concurrent increased risk of breast cancer. We compared adjusted risks of ...
    • First Observations of Recurring HF-Enhanced Topside Ion Line Spectra Near the Fourth Gyroharmonic 

      Rexer, Theresa; Gustavsson, Björn Johan; Leyser, Thomas; Rietveld, Michael T; Yeoman, Tim; Grydeland, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-28)
      We present first incoherent scatter radar observations of systematically recurring, high‐frequency (HF)‐enhanced ion line spectra at the topside F‐region ionosphere, during magnetic field aligned HF pumping in an O‐mode polarization. The European Incoherent Scatter UHF radar was directed in magnetic zenith on 9–11 March 2016 while stepping the pump frequency across the double resonance of the fourth ...
    • Interdisciplinary teaching as motivation: An initiative for change in post-16 vocational education 

      Holmbukt, Tove Elinor; Larsen, Annelise Brox (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      A team of researchers in teacher education and teachers in secondary education vocational study programmes decide to plan and try out interdisciplinary teaching schemes combining the subject English with Media studies. This is a two-stage study. Firstly, the research team want to observe whether an interdisciplinary approach to teaching and learning will have positive effects on students’ motivation ...
    • Using Machine Learning to Uncover Latent Research Topics in Fishery Models 

      Syed, Shaheen; Weber, Charlotte Teresa (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-16)
      Modeling has become the most commonly used method in fisheries science, with numerous types of models and approaches available today. The large variety of models and the overwhelming amount of scientific literature published yearly can make it difficult to effectively access and use the output of fisheries modeling publications. In particular, the underlying topic of an article cannot always be ...
    • Area and volume of mid-latitude glacier-like forms on Mars 

      Brough, Stephen; Hubbard, Bryn; Hubbard, Alun Lloyd (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-04)
      Although a substantial ice cover has been identified within the mid-latitudes of Mars, there is uncertainty regarding the formation, current and former volume, and dynamic evolution of these ice masses. Here, we present the first comprehensive ice volume estimate of martian glacier-like forms (GLFs) from systematic population scale mapping and volumetric analysis. The outlines of 1243 GLFs were ...
    • Could green artificial light reduce bycatch during Barents Sea Deep-water shrimp trawling? 

      Larsen, Roger B.; Herrmann, Bent; Sistiaga, Manu Berrondo; Brčić, Jure; Brinkhof, Jesse; Tatone, Ivan (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-31)
      The Nordmøre grid is widely used in shrimp trawls to reduce the bycatch of fish species. However, small-sized fish species and juveniles still pass through the grid and enter the codend, along with the targeted shrimp. This bycatch of small fish has a negative impact on the ecosystem due to increased fish mortality, and leads to additional sorting work onboard. Some small-sized fish that enter the ...
    • Holocene development of subarctic permafrost peatlands in Finnmark, northern Norway 

      Kjellman, Sofia E.; Axelsson, Pia E.; Etzelmüller, Bernd; Westermann, Sebastian; Sannel, A. Britta K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-01)
      Subarctic permafrost peatlands are important soil organic carbon pools, and improved knowledge about peat properties and peatland sensitivity to past climate change is essential when predicting future response to a warmer climate and associated feedback mechanisms. In this study, Holocene peatland development and permafrost dynamics of four subarctic peat plateaus in Finnmark, northern Norway have ...
    • Dual-specificity MAP kinase phosphatases in health and disease 

      Seternes, Ole Morten; Kidger, Andrew M; Keyse, Stephen M (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-08)
      It is well established that a family of dual-specificity MAP kinase phosphatases (MKPs) play key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in mammalian cells and tissues. MKPs provide a mechanism of spatiotemporal feedback control of these key signalling pathways, but can also mediate crosstalk between distinct MAP kinase cascades and facilitate interactions ...
    • Novel in situ gel-forming solid dosage form (gfSDF) prepared by the simple syringe-based moulding: A screening study 

      Falavigna, Margherita; Skalko-Basnet, Natasa; Cavallari, Cristina; Pini, Andrea; Luppi, Barbara; Di Cagno, Massimiliano Pio (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-05)
      The aim of this study was to prepare and optimize a novel type of in situ gel-forming solid dosage form (gfSDF) to be used in the treatment of mucosal/skin ulcerations. For this purpose, a simple but reliable syringe-based hot melt/moulding method was employed. Chloramphenicol (antibiotic) and ibuprofen (anti-inflammatory) were chosen as model active pharmaceutical ingredients (APIs) to be loaded ...
    • Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction 

      Kleveland, Ola; Ueland, Thor; Kunszt, Gabor; Bratlie, Marte; Yndestad, Arne; Broch, Kaspar; Holte, Espen; Ryan, Liv; Amundsen, Brage H.; Bendz, Bjørn; Aakhus, Svend; Espevik, Terje; Halvorsen, Bente; Mollnes, Tom Eirik; Wiseth, Rune; Gullestad, Lars; Aukrust, Pål; Damås, Jan Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-29)
      <p><i>Aim</i>: To evaluate the effect of interleukin-6 inhibition with tocilizumab on the cytokine network in patients with acute non-ST-elevation myocardial infarction (NSTEMI).</p> <p><i>Methods</i>: 117 patients with acute NSTEMI were randomised to an intravenous infusion of 280 mg tocilizumab or placebo prior to coronary angiography. Blood samples were obtained at baseline, at 6 consecutive ...