<p><i>Background</i>: Programmed death ligand 1 (PD-L1) targeting immunotherapies, as pembrolizumab and nivolumab, have significantly improved outcome in patients with non-small cell lung cancer (NSCLC). Tobacco smoking is the number one risk factor for lung cancer and is linked to 80%–90% of these cancers. Smoking during cancer therapy may influence on radiotherapy and chemotherapy outcome. We aimed ...

The main challenge for the European seafood industry is to ensure sustainable production volume while adapting to climate warming. Marine fisheries mainly target 41 species which account for 80% of the seafood production in Europe. The remaining 20% comes from marine and freshwater aquaculture, which harvest mainly 5 and 11 species, respectively. European seafood production volume (2004–2014) recorded ...

Einstein–Weyl structures on a three-dimensional manifold <i>M</i> are given by a system <i>E</i> of PDEs on sections of a bundle over <i>M</i>. This system is invariant under the Lie pseudogroup <i>G</i> of local diffeomorphisms on <i>M</i>. Two Einstein–Weyl structures are locally equivalent if there exists a local diffeomorphism taking one to the other. Our goal is to describe the quotient equation ...

Current archaeological evidence indicates the transition from hunting-fishing-gathering to agriculture in Northern Europe was a gradual process. This transition was especially complex in the prehistoric North Fennoscandian landscape where the high latitude posed a challenge to both domestic animal breeding and cereal cultivation. The conditions varied, the coastal dwellers had access to rich marine ...

Although rather delicate on account of their propensity to undergo deiodination, β-octaiodoporphyrinoids are of considerable interest as potential precursors to novel β-octasubstituted macrocycles. Presented herein are early results of our efforts to synthesize β-octaiodocorrole derivatives. Oxidative condensation of 3,4-diiodopyrrole and aromatic aldehydes failed to yield free-base octaiodocorroles. ...

We compare the macro-kinematics of six elite female cross-country skiers competing in 1.1-km Sprint and 10.5-km Distance classical technique events on consecutive days under similar weather and track conditions. The relative use of double pole (DP), kick-double pole (KDP), diagonal stride (DS), tucking (Tuck) and turning (Turn) subtechniques, plus each technique’s respective velocities, cycle ...

The east Greenland margin has been influenced by oceanographic and cryospheric processes since the late Miocene, when the southwards flow of the East Greenland Current (EGC) initiated and ice sheets first advanced across the margin. However, the relative importance of these processes, and their influence on the sedimentation of the margin through time remains poorly understood. High‐resolution ...

Understanding the statistics of fluctuation driven flows in the boundary layer of magnetically confined plasmas is desired to accurately model the lifetime of the vacuum vessel components. Mirror Langmuir probes (MLPs) are a novel diagnostic that uniquely allow us to sample the plasma parameters on a time scale shorter than the characteristic time scale of their fluctuations. Sudden large-amplitude ...

The Alcator C-Mod mirror Langmuir probe diagnostic is used to characterize plasma fluctuations in the outboard mid-plane scrape-off layer (SOL). Ohmically heated L-mode plasmas with Greenwald fractions from 0.1 to 0.45 are analyzed. In plasmas with a low line-averaged core density, the radial profiles of the average electron density and temperature feature a two-scale structure with a strong gradient ...

Little is known about the process from experiencing indeterminate bodily sensations to perceiving them as possible symptoms of cancer relapse. We explore how such processes are related to local values and to clinical practice in rural Northern Norway. One-year ethnographic fieldwork was conducted in a coastal village involving ten key participants residing in the village who had undergone cancer ...