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De lojale offiserer, en studie av deres reaksjoner på multiple endringer.
(Master thesis; Mastergradsoppgave, 2017-05-13)Formålet med denne utredningen er å øke forståelsen for reaksjonen til den endringsvante militært ansatte i Forsvaret. Utredningen er en singelcase studie av en hæravdeling Forsvaret. Metodisk tilnærming i oppgaven er kvalitative intervjuer, dataen til analysen presenteres og drøftes i samme kapittel. Samtlige intervju er transkribert samt at relevante funn har blitt analysert og tolket opp mot ... -
Liposomes as Potential Carrier for Bioactive β2,2- Amino Acid Derivatives - A Feasibility Study
(Master thesis; Mastergradsoppgave, 2015-05-13)The emergence of antibiotic resistant bacterial strains is a rising global problem that does not only result in fatal infections of previously treatable cases, but increases also the economic burden of health care systems. The same applies for cancer as treatment of some cancer types is difficult and also resistance to treatment is an increasing problem in cancer chemotherapy. Novel treatment ... -
Quantitative Phosphoprotein Analysis in Adipose Tissue
(Master thesis; Mastergradsoppgave, 2016-05-13)Background: Mass spectrometry-based proteomics has increasingly been the choice of method for the global analysis of the composition, modification and dynamics of proteins. Quantitative analysis of the proteome with tandem mass tag is a technique for calculating the relative abundance of the proteome in tissues and organelles. In this thesis, present a novel bottom-up method for the quantitative ... -
Molecular aspects of high-risk neuroblastoma and novel therapeutic opportunities
(Doctoral thesis; Doktorgradsavhandling, 2020-05-29)Neuroblastoma is a highly heterogenous cancer of childhood. High-risk disease has a poor prognosis with survival around 50% and cured patients suffer treatment related late effects. Better therapy is needed. Increased knowledge of the molecular biology of high-risk neuroblastomas is essential to devise new treatments. High-risk neuroblastomas are frequently MYCN-amplified (MNA). MNA is correlated ... -
MicroRNA-193b-3p represses neuroblastoma cell growth via downregulation of Cyclin D1, MCL-1 and MYCN
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-06)Neuroblastoma is the most common diagnosed tumor in infants and the second most common extracranial tumor of childhood. The survival rate of patients with high-risk neuroblastoma is still very low despite intensive multimodal treatments. Therefore, new treatment strategies are needed. In recent years, miRNA-based anticancer therapy has received growing attention. Advances in this novel treatment ... -
Exosome-like extracellular vesicles from MYCN-amplified neuroblastoma cells contain oncogenic miRNAs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015)<p><i>Background:</i> In recent years, evidence has accumulated indicating that both normal and cancer cells communicate via the release and delivery of macromolecules packed into extracellular membrane vesicles. <p><i>Materials and Methods:</i> We isolated nano-sized extracellular vesicles from MYCN-amplified neuroblastoma cell lines using ultracentrifugation and exosome precipitation (Exoquick) ... -
Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-12)Abnormal increases in nucleolar size and number caused by dysregulation of ribosome biogenesis has emerged as a hallmark in the majority of spontaneous cancers. The observed ribosome hyperactivity can be directly induced by the MYC transcription factors controlling the expression of RNA and protein components of the ribosome. Neuroblastoma, a highly malignant childhood tumor of the sympathetic nervous ... -
Salmon louse (Lepeophtheirus salmonis (Krøyer)) control methods and efficacy in atlantic salmon (Salmo salar (Linnaeus)) aquaculture: A literature review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-31)The salmon louse (<i>Lepeophtheirus salmonis</i>) causes problems in Atlantic salmon (<i>Salmo salar</i>) aquaculture in the Northern Hemisphere, because infestations can result in both a loss of production and in fish mortality. Several types of treatment have been used to control louse infestations, but these have seen varying success. The aim of this review is to examine the efficacy and safety ... -
Mesh sticking probability in fishing gear selectivity: Methodology and case study on Norway lobster (Nephrops norvegicus) and mantis shrimp (Squilla mantis) in the Mediterranean Sea creel fishery
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-27)Fish or crustaceans stuck in the fishing gear meshes can lead to operational problems in some fisheries and thereby affect the economic gain. However, mesh sticking probability has never been formally quantified as a part of the estimation of fishing gear size selectivity. Therefore, this study developed a size selection model and estimation procedure that, besides the size dependent retention and ... -
Legitimacy for Sustainability: A Case of A Strategy Change for An Oil and Gas Company
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-10)This study introduces and validates a measure of a company’s institutional profile for sustainability. It uses institutional theory as a lens to understand the factors that legitimize the adoption of renewable energy activities in an oil and gas company. The three institutional dimensions used in this study are regulative, normative and cognitive, which aimed to measure legitimacy in an oil and gas ... -
Isolation and characterization of antimicrobial peptides with unusual disulfide connectivity from the colonial ascidian Synoicum turgens
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-12)This study reports the isolation of two novel cysteine-rich antibacterial peptides, turgencin A and turgencin B, along with their oxidized derivatives, from the Arctic marine colonial ascidian <i>Synoicum turgens</i>. The peptides are post-translationally modified, containing six cysteines with an unusual disulfide connectivity of Cys<sup>1</sup>-Cys<sup>6</sup>, Cys<sup>2</sup>-Cys<sup>5</sup>, and ... -
Hvordan kan vi forstå barns tilfredshet med egen involvering i foreldremekling?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-03)I forskningsprosjektet «Høring av barn i mekling» har vi studert meklinger hvor barn og ungdom har vært involvert i meklingsprosessen gjennom en samtale med mekler uten foreldrene til stede. Barn og unge er i all hovedsak svært tilfredse med å delta. Hvordan kan vi forstå denne tilfredsheten? Og hva sier dette om kulturelle kontekster for barndom i dag og barns posisjon i meklingskonteksten? I denne ... -
Den matematiske samtalen i tradisjonelle og virtuelle klasserom. En sammenligning av lærernes kommunikasjon i de to klasserommene
(Master thesis; Mastergradsoppgave, 2018-05-12)Den matematiske samtalen i tradisjonelle og virtuelle klasserom er en kvalitativ studie hvor vi ser på lærernes bruk av samtaletrekk som redskap for å skape ei aktiv tilnærming til matematikkfaget i de to ulike klasseromsformene. Det teoretiske fundamentet for studien og datainnsamlingen tar utgangspunkt i Chapin et al. (2009) sine samtaletrekk (gjenta, repetere, resonnere, tilføye, vente, snu ... -
Debate: Corporatization in local government - the need for a comparative and multi-disciplinary research approach
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-28)During the past 20–30 years, scholars from different academic disciplines, as well as practitioners and local politicians, have observed a marked growth in the number of municipally-owned companies (MOCs) in local government service provision (Grossi & Reichard, 2008; Aars & Ringkjøb, 2011; Erlingsson, Fogelgren, Olsson, Thomasson, & Öhrvall, 2015; Ferry, Andrews, Skelcher, & Wegorowski, 2018). This ... -
Old antibiotics as alternative treatment options for urinary tract infections caused by ESBL-, AmpC- and carbapenemase-producing Escherichia coli
(Doctoral thesis; Doktorgradsavhandling, 2020-05-25)Multidrug-resistant (MDR) bacteria, including Escherichia coli, producing extended-spectrum β-lactamase (ESBL), AmpC or carbapenemases, are acknowledged among the most significant global health threats. Growing rates of MDR E.coli can lead to an increase in the use of reserve antimicrobials. Re-introducing “old antimicrobials” could offer a timely solution. This work aimed at evaluating the role of ... -
Body mass index and risk of malnutrition in community-living elderly men and women: relationships with morbidity, mortality and health- related quality of life. The Tromsø and HUNT studies
(Doctoral thesis; Doktorgradsavhandling, 2011-06-09)The elderly population is rapidly growing, and elderly individuals are more vulnerable to nutritional problems than other adults. A number of studies have found evidence for adverse health outcomes in elderly patients at risk of malnutrition. However, much of the previous research has been performed in hospital populations or in groups of elderly patients with specific diagnoses. More population-based ... -
Familieråd – metodetilpassing til samisk sosialt arbeid
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-02)I denne artikkelen diskuterer vi tilpassing av familieråd til ein samisk kontekst. Studien bygger på intervju med sosialarbeidarar i samiske område. Vi finn at familierådsmodellen sitt teoretiske grunnlag bør tematisere samisk storfamilie, samiske kommunikasjonsformer, samiske ideal for barnet si deltaking og familierådskoordinator si lokale tilknyting. Det teoretiske grunnlaget må diskutere at ... -
Er spastisitet i beina, målt med Modified Ashworth Scale, assosiert med gange og balanse hos personer med multippel sklerose?
(Master thesis; Mastergradsoppgave, 2016-05-10)Bakgrunn: Spastisitet er et symptom som skyldes skade eller sykdom i sentralnervesystemet, og oppstår hos over 80 % av personer med multippel sklerose. Spastisitet er funnet å redusere livskvalitet, bevegelsesevnen og gir ofte smerter. Assosiasjonen mellom spastisitet, balanse og gangfunksjon er hittil ikke etablert. Det er heller ingen enighet om hvordan spastisitet best bør måles. Formålet med ... -
Sammenheng mellom mindset og tankestrategi
(Master thesis; Mastergradsoppgave, 2019-05-09)Prefaktiske tanker – tanker om konsekvenser av tenkte handlinger før de utføres – kan være gunstig for å forstå hvordan fremtidige mål kan oppnås. (Epstude, Scholl & Roese, 2016), mens kontrafaktisk tanker – tanker om hva som alternativt kunne skjedd – er funksjonell ved å hjelpe individet med atferdsregulering (Epstude & Roese, 2008). Denne studien undersøker sammenhengen mellom studenters prefaktiske- ... -
Responsible diffusion of digital healthcare innovation
(Master thesis; Mastergradsoppgave, 2020-02-28)Digital healthcare is an area, which is opening up for business opportunities. However, there has been a lot of research here from a long time. The involvement of stakeholders in the innovation process is increasing and with this situation, the diffusion of such healthcare innovation in market is evolving. To explain the effect of stakeholder’s involvement in the innovation process on the diffusion ...
