<p>The work presented in this dissertation combines two fully independent approaches to achieve compound libraries for anticancer drug research. <p>Project 1: Development of compounds inhibiting human dUTPase as an amplifier of a thymidylate synthase inhibitor based cancer therapy <p>The human dUTPase has received increased attention as a drug target in the recent years. Its inhibition can ...

Artikeln bedriver en litteraturhistoriskt orienterad läsning av Josefine Klougarts <i>Om mørke</i> (2013). Artikeln argumenterar för att Klougarts roman stilistiskt och strukturellt är inspirerad av Virginia Woolfs författarskap, och att Klougart skriver in sig i en tradition av litterär impressionism. Även romanens bruk av stream of consciousness-teknik och dess fragmentestetik sätts i relation ...

The species of <i>Massalongia</i> recorded and described from the Southern Hemisphere are revised and it is shown that only one is present; <i>M. patagonica</i> which is widespread, with populations in Australia and New Zealand that differ from the South American populations, but at present best regarded as part of the variation of that species. Records from this hemisphere of all other species ...

Much has been said and written about the Ukrainian revolution of 2013–14, yet research on Maidan Nezalezhnosti, the protests’ most iconic location, has thus far been rather limited. This article analyses the history, attributes and symbolism of this particular city space. What function does Maidan have in the Ukrainian society? In the cause of my fieldwork in Kyiv 2013–15 on the recent revolution, ...

From 2007 to 2015, eight wells were drilled and fully cored to test the feasibility of storing CO₂ emitted from the coal-fueled power plant in Longyearbyen, Svalbard. The drilling campaign identified three water-bearing sandstone aquifers; i) a lower aquifer in Upper Triassic strata; ii) a middle aquifer in Upper Triassic to Middle Jurassic; and iii) an upper aquifer in Lower Cretaceous ...

Although cryptogamic covers are important ecosystem engineers in high Arctic tundra, they were often neglected in vegetation surveys. Hence we conducted a systematic survey of cryptogamic cover and vascular plant coverage and composition at two representative, but differing Arctic sites (Ny-Ålesund, Svalbard) along catenas with a natural soil moisture gradient, and integrated these data with ...

In this work, we demonstrate that the indole-oxazole-pyrrole framework of the breitfussin family of natural products is a promising scaffold for kinase inhibition. Six new halogenated natural products, breitfussin C–H (3 – 8) were isolated and characterized from the Arctic, marine hydrozoan Thuiaria breitfussi. The structures of two of the new natural products were also confirmed by total synthesis. ...

<i>Objectives</i> - The aim of the current study is to investigate what males experience as helpful in their recovery process from eating disorders (ED).<p> <p><i>Methods</i> - Qualitative in-depth interviews within a phenomenological approach, and using content analysis to excavate overarching text themes.<p> <p><i>Setting</i> - Norway and Sweden.<p> <p><i>Participants</i> - Included were ...

<i>Introduction</i> - Diarrhea-predominant irritable bowel syndrome (IBS-D) is a gastrointestinal disease with a high incidence and no effective drugs available. Compound Glutamine Entersoluble Capsules (CGEC) is a compound preparation integrating Sijunzi Decoction and L-Glutamine. The aim of this systematic review was to evaluate the clinical effects and safety of CGEC for IBS-D.<p> <p><i>Methods</i> ...

<i>Introduction</i> - Long-term childhood cancer survivors are at risk for frailty and have significant health-related issues in adulthood. Various health promotion interventions have been proposed to enhance quality of life including wilderness therapy, which applies the impact of nature on health in a therapeutic context. Previous studies have described positive outcomes linked with various ...