Estrogens receptors (ER) are involved in several sociosexual behaviors and fear responses. In particular, the ERα is important for sexual behaviors, whereas ERβ modulates anxiolytic responses. Using shRNA directed either against the ERα or the ERβ RNAs (or containing luciferase control) encoded within an adeno-associated viral vector, we silenced these receptors in the ventromedial nucleus of the ...

The aim of this thesis is to examine how the use of context data in scheduling tools can contribute to the reduction of elective surgery cancellations. A literature review, following the recommendations to systematic reviews, was conducted in order to gather information on what context data could be used to improve elective surgery scheduling, and how the use of these data could affect elective ...

Neuroblastoma is the most common solid tumor in infants. Most of the children diagnosed above one year of age, shows metastatic disease and poor prognosis. Chemotherapy is one of the principle mode of treatment. However, resistance to drug represent a major clinical obstacle for the effective treatment of cancer. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression, ...

Bacterial natural products have contributed with a large part of the bioactive compounds that lead to drugs, and the biggest portion of the marketed antibiotics are bacterial products or their derivatives. Marine bacteria are not yet investigated to the same extend as their terrestrial counterparts. Therefore, they are considered a promising source for novel bioactive metabolites for drug development, ...

Stromal cells in the tumor microenvironment (TME) interacts with cancer cells and affect their behavior in diverse manners. In this study, we investigated in vitro the mechanisms by which non-irradiated and irradiated cancer-associated fibroblasts (CAFs) isolated from patients with non-small cell lung carcinoma (NSCLC) affected the phenotype and function of monocyte-derived dendritic cells (Mo-DCs) ...

The number of cellular Internet of Things (IoT) connections is expected to grow at a rate of 30% each year and is reaching into the billions by 2019. The world of IoT can be fragmented since data sources span a wide variety of protocols, API's, authentication methods and file formats. Data collection and processing can be complex and producing visualizations for value extraction can be a tedious ...

Barn deltar i økende grad i familievernkontorenes obligatoriske foreldremekling ved samlivsbrudd. Det er i dag en fagpolitisk målsetting i Norge at dette skal bli regelen snarere enn unntaket. På denne måten skal barns rett til å bli hørt innfris. I denne artikkelen undersøkes mekleres erfaringer fra meklingsprosesser der barn har deltatt. Spørsmålet som stilles er: Hva gjør barns deltakelse med ...

This paper is focused on investigations of the improved correction of the effect of variation in incidence angle on ScanSAR data. Conventional correction methods (such as LLM, locally linear mapping) typically assume that each target class has a similarity distribution in the middle of the image. The objectives of this study are to extend the correction algorithm to full swath width without any ...

The number of good sites in less exposed locations for aquaculture farming is limited. Trends are now that the fish cages are increasing in both width and depth, as well as more weather-exposed locations, are taken into use. As the net cages continue to increase in size, so does the material costs. The design of the sea cages should be modified for safe and reliable use in remote offshore locations. ...

The response of ionospheric plasma to pumping by powerful HF (high frequency) electromagnetic waves transmitted from the ground into the ionosphere is the strongest in the direction of geomagnetic zenith. We present experimental results from transmitting a left-handed circularly polarized HF beam from the EISCAT (European Incoherent SCATter association) Heating facility in magnetic zenith. The ...