Viser treff 6521-6540 av 36353

    • Usability of the IDDEAS prototype in child and adolescent mental health services: A qualitative study for clinical decision support system development 

      Clausen, Carolyn Elizabeth; Leventhal, Bennett; Nytrø, Øystein; Koposov, Roman A; Røst, Thomas Brox; Westbye, Odd Sverre; Koochakpour, Kaban; Frodl, Thomas; Stien, Ulrika Line; Skokauskas, Norbert (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-23)
      Introduction: Child and adolescent mental health services (CAMHS) clinical decision support system (CDSS) provides clinicians with real-time support as they assess and treat patients. CDSS can integrate diverse clinical data for identifying child and adolescent mental health needs earlier and more comprehensively. Individualized Digital Decision Assist System (IDDEAS) has the potential to improve ...
    • Novel serum biomarkers and their association with measured and estimated GFR decline in the general population 

      Enoksen, Inger Therese Tønsberg (Doctoral thesis; Doktorgradsavhandling, 2023-09-29)
      Chronic kidney disease (CKD) is an increasing health problem globally, now affecting 8-13% of the world’s population. The prevalence of CKD increases dramatically with age because kidney function, as assessed by the glomerular filtration rate (GFR), declines with age. The rate of GFR loss varies significantly between individuals regardless of known risk factors. However, current kidney biomarkers ...
    • Determinants of language change in the Gurage area of Ethiopia 

      Feleke, Tekabe Legesse (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-27)
      This study aims to examine linguistic and non-linguistic determinants that contribute to language change in the Gurage area of Ethiopia. The linguistic and non-linguistic determinants were investigated by combining methods of dialectometry and mutual intelligibility. Principally, the study was interested in the potential influences of three linguistic factors (mutual intelligibility, contact-induced ...
    • A clinically motivated self-supervised approach for content-based image retrieval of CT liver images 

      Wickstrøm, Kristoffer; Østmo, Eirik Agnalt; Radiya, Keyur; Mikalsen, Karl Øyvind; Kampffmeyer, Michael; Jenssen, Robert (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-09)
      Deep learning-based approaches for content-based image retrieval (CBIR) of computed tomography (CT) liver images is an active field of research, but suffer from some critical limitations. First, they are heavily reliant on labeled data, which can be challenging and costly to acquire. Second, they lack transparency and explainability, which limits the trustworthiness of deep CBIR systems. We address ...
    • Lignocellulose Conversion via Catalytic Transformations Yields Methoxyterephthalic Acid Directly from Sawdust 

      Pedersen, Simon S.; Batista, Gabriel M. F.; Henriksen, Martin L.; Hammershøj, Hans Christian D.; Hopmann, Kathrin Helen; Skrydstrup, Troels (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-10)
      Poly(ethylene terephthalate) polyester represents the most common class of thermoplastic polymers widely used in the textile, bottling, and packaging industries. Terephthalic acid and ethylene glycol, both of petrochemical origin, are polymerized to yield the polyester. However, an earlier report suggests that polymerization of methoxyterephthalic acid with ethylene glycol provides a methoxy-polyester ...
    • Investigation of tetrasubstituted heterocycles reveals hydantoins as a promising scaffold for development of novel antimicrobials with membranolytic properties 

      Langer, Manuel K; Rahman, Ataur; Dey, Hymonti; Anderssen, Trude; Blencke, Hans-Matti; Haug, Tor; Stensvåg, Klara; Strøm, Morten B.; Bayer, Annette (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-24)
      Mimics of antimicrobial peptides (AMPs) have been proposed as a promising class of antimicrobial agents. We report the analysis of five tetrasubstituted, cationic, amphipathic heterocycles as potential AMP mimics. The analysis showed that the heterocyclic scaffold had a strong influence on the haemolytic activity of the compounds, and the hydantoin scaffold was identified as a promising template for ...
    • Highly sensitive quantitative phase microscopy and deep learning aided with whole genome sequencing for rapid detection of infection and antimicrobial resistance 

      Ahmad, Azeem; Hettiarachchi, Ramith; Khezri, Abdolrahman; Ahluwalia, Balpreet Singh; Wadduwage, Dushan; Ahmad, Rafi (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-12)
      Current state-of-the-art infection and antimicrobial resistance (AMR) diagnostics are based on culture-based methods with a detection time of 48–96 h. Therefore, it is essential to develop novel methods that can do real-time diagnoses. Here, we demonstrate that the complimentary use of label-free optical assay with whole-genome sequencing (WGS) can enable rapid diagnosis of infection and AMR. Our ...
    • Why in my backyard (WIMBY): Forging the link to community futures when energy transition projects are met with indifference 

      Svartdal, Inger Helene; Kristoffersen, Berit (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-20)
      This paper analytically works towards foregrounding a new concept which can be useful to describe local reception and perceptions related to energy transition projects: Why in my backyard (WIMBY). We define this concept as local indifference to take part in changes in local energy landscapes at the community level. Based on the reception and data from two pilot and demonstration projects in Arctic ...
    • Påvisning av tilbakefall og overlevelse ved akutt lymfatisk leukemi hos barn i Norge i perioden 1992-2016, en kohortstudie 

      Næss, Mathilde (Master thesis; Mastergradsoppgave, 2020-08-31)
      Innledning: Akutt lymfatisk leukemi (ALL) er den vanligste kreftsykdommen hos barn. Det nordiske samarbeidet NOPHO utarbeider behandlingsstrategier mot kreftsykdommer hos barn og gjennom de siste tiårene har forbedret antileukemisk behandling gitt økt overlevelse av ALL. Barn behandlet for ALL følges med jevnlige rutinekontroller. Det er lite forskning som har vurdert rutinekontrollenes betydning ...
    • The Departure from Mixed-Layer Similarity During the Afternoon Decay of Turbulence in the Free-Convective Boundary Layer: Results from Large-Eddy Simulations 

      Elguernaoui, Omar; Reuder, Joachim; Li, Dan; Maronga, Bjørn; Bakhoday Paskyabi, Mostafa; Wolf, Tobias; Esau, Igor (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-21)
      This study analyses the departure of the velocity-variances profiles from their quasi-steady state described by the mixed-layer similarity, using large-eddy simulations with different prescribed shapes and time scales of the surface kinematic heat flux decay. Within the descriptive frames where the time is tracked solely by the forcing time scale (either constant or time-dependent) describing the ...
    • Belief in COVID-19 Conspiracy Theories, Level of Trust in Government Information, and Willingness to Take COVID-19 Vaccines Among Health Care Workers in Nigeria: Survey Study 

      Oyeyemi, Sunday Oluwafemi; Fagbemi, Stephen; Busari, Ismaila Iyanda; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-02)
      Background: The World Health Organization recently declared vaccine hesitancy or refusal as a threat to global health. COVID-19 vaccines have been proven efficacious and are central to combatting the pandemic. However, many—including skilled health care workers (HCWs)—have been hesitant in taking the vaccines. Conspiracy theories spread on social media may play a central role in fueling vaccine ...
    • Improved procedures for production and purification of 135La from enriched [135Ba]BaCO3 on a 16.5 MeV cyclotron 

      Pedersen, Kristina Søborg; Deville, Claire; Søndergaard, Ursula; Jensen, Mikael; Jensen, Andreas I. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-08)
      Lanthanum-135 (<sup>135</sup>La) is a favorable Auger electron emitter with a high Auger electron yield and low gamma emission, making it promising for Auger electron radiotherapy. However, successful application requires reliable and scalable <sup>135</sup>La production. Up to now, metallic natural barium (<sup>nat</sup>Ba) is a commonly used target material, but this material is sensitive to ...
    • Contrasting the phospholipid profiles of two neoplastic cell lines reveal a high PC:PE ratio for SH-SY5Y cells relative to A431 cells 

      Bariås, Espen; Jakubec, Martin; Førsund, Elise; Hjørnevik, Linda Veka; Lewis, Aurelia Eva; Halskau, Øyvind (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-14)
      Lipids have been implicated in Parkinson's Disease (PD). We therefore studied the lipid profile of the neuroblastoma SH-SY5Y cell line, which is used extensively in PD research and compared it to that of the A431 epithelial cancer cell line. We have isolated whole cell extracts (WC) and plasma membrane (PM) fractions of both cell lines. The isolates were analyzed with 31P NMR. We observed a significant ...
    • Glucagon-like peptide 1 aggregates into low-molecular-weight oligomers off-pathway to fibrillation 

      Přáda Brichtová, Eva; Monika, Krupová; Bouř, Petr; Lindo, Viv; Gomes dos Santos, Ana; Jackson, Sophie E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-20)
      The physical stability of peptide-based drugs is of great interest to the pharmaceutical industry. Glucagon-like peptide 1 (GLP-1) is a 31-amino acid peptide hormone, the analogs of which are frequently used in the treatment of type 2 diabetes. We investigated the physical stability of GLP-1 and its C-terminal amide derivative, GLP-1-Am, both of which aggregate into amyloid fibrils. While off-pathway ...
    • Impact of GLP-1 receptor agonist versus omega-3 fatty acids supplement on obesity-induced alterations of mitochondrial respiration 

      Jansen, Kirsten Maria; Dahdah, Norma; Gama-Perez, Pau; Schots, Pauke C.; Larsen, Terje; Garcia-Roves, Pablo M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-23)
      Objective: To compare administration of the glucagon-like peptide-1 (GLP-1) analogue, exenatide, versus dietary supplementation with the omega-3 fatty acid-rich Calanus oil on obesity-induced alterations in mitochondrial respiration.<p> <p>Methods: Six-week-old female C57BL/6JOlaHSD mice were given high fat diet (HFD, 45% energy from fat) for 12 weeks to induce obesity. Thereafter, they were ...
    • The capability of square-meshes and fixed-shape meshes to control codend size selection 

      Bak-Jensen, Zita; Santos, Juan; Melli, Valentina; Stepputtis, Daniel; Feekings, Jordan P.; Herrmann, Bent (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-11)
      Trawl codends are commonly made of diamond-mesh netting. However, diamond-mesh codends vary in mesh geometry along its length and during fishing due to catch build up. This introduces variability in the size selection process. This phenomenon compromises the rationality of regulating exploitation patterns in trawl fisheries through adjustments in codend mesh size. One technical solution often ...
    • Sustained year-round oceanographic measurements from Rothera Research Station, Antarctica, 1997–2017 

      Venables, Hugh; meredith, mike; Hendry, Katharine R; hoopen, Petra Ten; Peat, Helen J; Chapman, Alice; Beaumont, Jennifer; rayner, piper; Miller, Andrew; Mann, Paul; Rossetti, Helen; Massey, Alison; SOUSTER, TERRI; Reeves, Simon; Fenton, Mairi; Heiser, Sabrina; Pountney, Samuel M.; Reed, Sarah; waring, zoe; clark, Marlon; bolton, emma; Mathews, Ryan; London, Hollie; Clement, Alice; stuart, emma; aurelia, reichardt; brandon, mark; Leng, Melanie; arrowsmith, carol; annett, amber; Henley, Sian F; Clarke, Andrew (Journal article; Tidsskriftartikkel, 2023-05-10)
      Oceanographic changes adjacent to Antarctica have global climatic and ecological impacts. However, this is the most challenging place in the world to obtain marine data due to its remoteness and inhospitable nature, especially in winter. Here, we present more than 2000 Conductivity-Temperature-Depth (CTD) profiles and associated water sample data collected with (almost uniquely) full year-round ...
    • Extreme Horizontal Wind Perturbations in the Mesosphere and Lower Thermosphere Over South America Associated With the 2022 Hunga Eruption 

      Poblet, Facundo L.; Chau, Jorge L.; Conte, J. Federico; Vierinen, Juha; Suclupe, Jose; Liu, Alan; Rodriguez, Rodolfo R. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-13)
      On 15 January 2022, the Hunga volcano produced a massive explosion that generated perturbations in the entire atmosphere. Nonetheless, signatures in the mesosphere and lower thermosphere (MLT) have been challenging to identify. We report MLT horizontal wind perturbations using three multistatic specular meteor radars on the west side of South America (spanning more than 3,000 km). The most ...
    • Timber as a Marine Resource: Exploitation of Arctic Driftwood in the North Atlantic 

      Mooney, Dawn Elise; Guðmundsdóttir, Lísabet; Pinta, Élie; Alm, Torbjørn (Journal article; Tidsskriftartikkel, 2023-03-07)
      The North Atlantic islands of the Faroe Islands, Iceland and Greenland have always been relatively poor in terms of native timber resources, due to their cold climate and exposed topography. Nevertheless, timber was vital to the material culture of the Norse settlers of these islands, and driftwood often met this need. As in subarctic Norway, where trees are also scarce, driftwood use and ownership ...
    • Time-varying market efficiency of safe-haven assets 

      Okoroafor, Ugochi Chibuzor; Leirvik, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-29)
      This study investigates the hedge and safe-haven possibilities with bitcoin, gold and crude oil in different equity markets in the presence of time-varying market inefficiency. Our results indicate that periods of market inefficiency for the Bitcoin, gold and crude oil price positively influence their function as a hedge asset for the equity markets of Japan, China, the US, Europe and emerging ...