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Non-Homologous End Joining Factors XLF, PAXX and DNA-PKcs Maintain the Neural Stem and Progenitor Cell Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-28)Non-homologous end-joining (NHEJ) is a major DNA repair pathway in mammalian cells that recognizes, processes and fixes DNA damage throughout the cell cycle and is specifically important for homeostasis of post-mitotic neurons and developing lymphocytes. Neuronal apoptosis increases in the mice lacking NHEJ factors Ku70 and Ku80. Inactivation of other NHEJ genes, either <i>Xrcc4</i> or <i>Lig4</i>, ... -
Studying phenological phenomena in subarctic biomes with international school pupils as citizen scientists
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-30)Citizen science can facilitate in‐depth learning for pupils and students, contribute to scientific research, and permit civic participation. Here, we describe the development of the transnational school‐based citizen science project <i>Phenology of the North Calotte</i>. Its primary goal is to introduce pupils (age 12–15; grades 7–10) in northern Norway, Russia, and Finland to the local and global ... -
Sensitivity Analysis and Case Studies for CO2 Transportation Energy Consumption
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020)The transportation of CO2 is important to all Carbon Capture and Storage (CCS) projects. Both the infrastructure costs – compressors, pipelines, tanker ships, etc. – and the energy consumed in the compression or liquefaction of CO2 are significant. Understanding how the size, capacity and energy consumption of transportation alternatives varies between projects is therefore important. Modelling ... -
Reduced grey- and white matter volumes due to unilateral hearing loss following treatment for vestibular schwannoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-03)<i>Objective</i> - Previous studies of the consequences of unilateral hearing loss (UHL) on the functional-structural organization of the brain has included subjects with various degrees of UHL. We suggest that the consequences of a total loss of hearing in one ear might differ from those seen in subjects with residual hearing in the affected ear. Thus, the main aim of the present study was to compare ... -
Genetic Diversity of the Noncoding Control Region of the Novel Human Polyomaviruses
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-07)The genomes of polyomaviruses are characterized by their tripartite organization with an early region, a late region and a noncoding control region (NCCR). The early region encodes proteins involved in replication and transcription of the viral genome, while expression of the late region generates the capsid proteins. Transcription regulatory sequences for expression of the early and late genes, as ... -
Double vs single primary tooth extraction in interceptive treatment of palatally displaced canines: A randomized controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-21)<i>Objectives</i> - To compare the impact of primary canine and primary first molar extractions with extractions of only the primary canine regarding correction of palatally displaced canines (PDCs).<br><br> <i>Materials and Methods</i> - Thirty-two children aged 9.5–13.5 years with 48 PDCs were randomly allocated to either the double-extraction group (DEG) or single-extraction group (SEG). Clinical ... -
Modernitet og modernitetskritikk i Emils Durkheims sosiologi
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-07)Durkheims forhold til det moderne er preget av ambivalens. Han er kollektivist/holist når det gjelder sosiologiske forklaringer. Samfunnet er en egen realitet og en kraft som påvirker individenes tankeliv, følelser og motiver, om enn ikke i alle detaljer. Men selv om han er metodologisk kollektivist, er det ikke nødvendigvis slik at han også er kollektivist når det gjelder politiske og moralske ... -
Liposomes-in-hydrogel delivery system enhances the potential of resveratrol in combating vaginal chlamydia infection
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-11)<i>Chlamydia trachomatis</i> is the most common cause of bacterial sexually transmitted infections and causes serious reproductive tract complications among women. The limitations of existing oral antibiotics and treatment of antimicrobial resistance require alternative treatment options. We are proposing, for the first time, the natural polyphenol resveratrol (RES) in an advanced delivery system ... -
Towards mass cultivation of diatoms as a source of marine lipids
(Doctoral thesis; Doktorgradsavhandling, 2021-04-23)The global demand for the long-chain omega-3 fatty acids EPA and DHA is increasing, and the traditional sources of these fatty acids, fish oils, are no longer able to sustain the demand. This shortage is mainly a result of the surging requirement of EPA and DHA as ingredients in fish feed for aquaculture, and as dietary supplements for human consumption. As a result, there is an increased interest ... -
Photoperiodic history-dependent preadaptation of the smolting gill. Novel players and SW immediate response as markers of growth and welfare
(Doctoral thesis; Doktorgradsavhandling, 2021-04-16)This thesis presents a rich introduction to the evolution, life history and physiology of Atlantic salmon, with a special emphasis on the developmental transitions (termed smolting) juvenile salmon pass through has they prepare to migrate from their native freshwater habitat to the sea. The introduction provides a comprehensive background on chronobiology and osmoregulation in fishes and links this ... -
En kvalitativ undersøkelse om ungdommers opplevde grunner til å delta i organisert idrett og foreldrenes betydning for idrettsdeltakelsen. Intervju med ungdommer og foreldre
(Master thesis; Mastergradsoppgave, 2021-03-11)<p>Jeg skal i studien gi svar på mine tre problemstillinger. <p>Denne oppgaven har blant annet som formål å avdekke ungdommers grunner til at de selv deltar i lagidrett. De andre to problemstillingene ser fra både ungdom og foreldrenes perspektiver om hvordan de opplever hvordan foreldrene påvirker idrettsdeltakelsen til sine barn. <p>I min oppgave har jeg brukt teori av blant annet Seippel, ... -
Ungdom og familie ressurser - En studie av deltakelse i idrett, friluftsliv og snøscooterkjøring blant ungdom i Finnmark med ulik familieøkonomi
(Master thesis; Mastergradsoppgave, 2021-01-19)Formålet med denne studien var å belyse sosiale forskjeller i deltakelse i fritidsaktiviteter og bruk av fritidsarenaer blant ungdom med ulik sosioøkonomisk status i Finnmark. Ved å se på ungdom fra familier med ulik økonomi og ulik tilgang til materielle ressurser, var siktemålet å få kunnskap om hvordan familiens sosioøkonomiske status påvirker ungdoms deltakelse i idrett og fysisk aktivitet, ... -
Circadian-based processes in the High Arctic: activity, thermoregulation and photoperiodism in the Svalbard ptarmigan (Lagopus muta hyperborea)
(Doctoral thesis; Doktorgradsavhandling, 2021-04-15)<p>This thesis addresses aspects of the circadian and photoperiodic system in a High Arctic bird: the Svalbard ptarmigan (<i>Lagopus muta hyperborea</i>, Sundevall 1845). The most northern resident bird inhabits a unique photic environment; 2/3 of its year it spends either under a night without sunrise (polar night) or under a never setting Sun (polar day). Studies so far suggest a temporal loss of ... -
Kunnskapsoppsummering og klassifisering av tiltaket: Circle of Security Virginia – Gruppemodellen (COS-VG) (2. utg.)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-02)<i>BAKGRUNN</i> - Circle of Security (COS), eller <i>Trygghetssirkelen</i> på norsk, er en gruppe intervensjoner utviklet for å fremme god tilknytning mellom foreldre og barn. Intervensjonene retter seg primært mot foreldrenes evne til å forstå barnets grunnleggende behov for trygghet, tilhørighet og autonomi slik at barnets trygghetsfølelse og selvforståelse øker. Denne kunnskapsoppsummeringen ... -
Kunnskapsoppsummering og klassifisering av tiltaket: Telemarksmodellen: Vegen blir til mens vi går den sammen (1.utg.)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-01)<i>Bakgrunn</i> - Telemarksmodellen er en kursrekke utviklet for å fremme psykisk helse og forebygge sosiale vansker for barn som har forståelsesvansker i form av en lett psykisk utviklingshemming. Kursene gis når barnet går på mellomtrinnet i barneskole, ungdomstrinnet og i videregående skole. Formen er psykoedukativ hvor en veksler mellom informasjon, råd, veiledning og samtale om et hverdagsliv ... -
Tuberkulose som tegn på virkelighet i Hamsuns Victoria (1898)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-10)I Victoria (1898) av Knut Hamsun dør den kvinnelige hovedpersonen av tuberkulose bare 23 år gammel. Victoria er en av Hamsuns mest kjente romaner, men tuberkulosen som motiv har kun i liten grad påkalt kritikernes interesse. I denne artikkelen vil jeg drøfte hvordan fremstillingen av tuberkulose korresponderer med Hamsuns egen sykdomserfaring, samt med de rådende historiske og kulturelle forestillinger ... -
Northern Genealogies in ‘The Snow Queen’ and Frozen
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-10)H. C. Andersen’s ‘The Snow Queen’ (1844) and its self-professed adaptation Frozen (2013) both maintain a combined focus on origins and development. I approach the two texts as narratives that explain aspects of human life by showing how they came into being – as accounts that, although not primarily historical, are still bound up with genealogical ways of thinking: how, and from what beginnings, do ... -
Den Norden lesen: Erinnerungen, Wahrnehmungen und Bedeutungen im interdisziplinären Dialog
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-10)Unser Beitrag basiert auf der Methode der dramatischen Montage (Klok & Haselmann 2019). In der Begegnung mit zwei autoethnografischen literarischen Quellen, „Die Doktorsfamilie im hohen Norden“ (Gjems Selmer 1905) und „Eine Frau erlebt die Polarnacht“ (Ritter 1938), bewegen wir uns im Zwischenraum zeitlich und disziplinär getrennter Denkwelten. In unserer jeweiligen Rolle als Kulturwissenschaftlerin ... -
Irradiated tumor fibroblasts avoid immune recognition and retain immunosuppressive functions over NK cells
(Journal article; Tidsskriftartikkel, 2021-01-22)Recent studies have demonstrated that radiotherapy is able to induce anti-tumor immune responses in addition to mediating direct cytotoxic effects. Cancer-associated fibroblasts (CAFs) are central constituents of the tumor stroma and participate actively in tumor immunoregulation. However, the capacity of CAFs to influence immune responses in the context of radiotherapy is still poorly understood. ... -
Salmonid Alphavirus Subtype 3 Induces Prolonged Local B Cell Responses in Atlantic Salmon (Salmo salar) After Intraperitoneal Infection
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-10)B cell responses are a crucial part of the adaptive immune response to viral infection. Infection by salmonid alphavirus subtype 3 (SAV3) causes pancreas disease (PD) in Atlantic salmon (<i>Salmo salar</i>) and is a serious concern to the aquaculture industry. In this study, we have used intraperitoneal (IP) infection with SAV3 as a model to characterize local B cell responses in the peritoneal ...
