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Fibroblast miR-210 overexpression is independently associated with clinical failure in Prostate Cancer – a multicenter (in situ hybridization) study

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https://hdl.handle.net/10037/10272
DOI
https://doi.org/10.1038/srep36573
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article.pdf (645.2Kb)
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Dato
2016-11-08
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Andersen, Sigve; Richardsen, Elin; Moi, Line; Dønnem, Tom; Nordby, Yngve; Ness, Nora; Eilertsen Holman, Marte; Bremnes, Roy M.; Busund, Lill-Tove
Sammendrag
There is a need for better prognostication in prostate cancer (PC). “The micromanager of hypoxia”, microRNA-210 (miR-210) is directly linked to hypoxia, is overexpressed in PC and has been implied in tumor cell-fibroblast crosstalk. We investigated the prognostic impact of miR-210 in tumor cells and fibroblasts in PC. Tumor and stromal samples from a multicenter PC cohort of 535 prostatectomy patients were inserted into tissue microarrays. To investigate the expression of miR-210, we used in situ hybridization and two pathologists semiquantitatively scored its expression. Overexpression of miR-210 in tumor cells was not associated to biochemical failure-free survival (BFFS, p=0.85) or clinical failure-free survival (CFFS, p=0.09). However, overexpression of miR-210 in fibroblasts was significantly associated to a poor CFFS (p=0.001), but not BFFS (p=0.232). This feature was validated in both cohorts. Overexpression of miR-210 was independently associated with a reduced CFFS (HR=2.76, CI 95% 1.25–6.09, p=0.012). Overexpression of miR-210 in fibroblasts is independently associated with a poor CFFS. This highlights the importance of fibroblasts and cellular compartment crosstalk in PC. miR-210 is a candidate prognostic marker and potential therapeutic target in PC.
Beskrivelse
This is an open access article distributed under the terms of the Creative Commons Attribution License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.
This article is also available via DOI:10.1038/srep36573
Forlag
Nature Publishing Group
Sitering
Andersen S, Richardsen ER, Moi LLH, Dønnem T, Nordby Y, Ness N, Eilertsen Holman M, Bremnes RM, Busund LTRB. Fibroblast miR-210 overexpression is independently associated with clinical failure in Prostate Cancer – a multicenter (in situ hybridization) study. Scientific Reports (2016) 6:36573
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  • Artikler, rapporter og annet (medisinsk biologi) [1103]
  • Artikler, rapporter og annet (klinisk medisin) [1974]

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