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dc.contributor.authorGrindstad, Thea
dc.contributor.authorSkjefstad, Kaja
dc.contributor.authorAndersen, Sigve
dc.contributor.authorNess, Nora
dc.contributor.authorNordby, Yngve
dc.contributor.authorAl-Saad, Samer
dc.contributor.authorFismen, Silje
dc.contributor.authorDønnem, Tom
dc.contributor.authorRakaee, Mehrdad
dc.contributor.authorBusund, Lill-Tove
dc.contributor.authorBremnes, Roy M.
dc.contributor.authorRichardsen, Elin
dc.date.accessioned2017-02-27T09:19:22Z
dc.date.available2017-02-27T09:19:22Z
dc.date.issued2016-09-09
dc.description.abstractAndrogens are considered important in normal prostate physiology and prostate cancer (PCa) pathogenesis. However, androgen-targeted treatment preventing PCa recurrence is still lacking. This indicates additional mediators contributing to cancer development. We sought to determine the prognostic significance of estrogen receptors, ERα and -β, and the aromatase enzyme in PCa. Tissue microarrays were created from 535 PCa patients treated with radical prostatectomy. Expression of ERα, ERβ and aromatase were evaluated using immunohistochemistry. Representative tumor epithelial (TE) and tumor stromal (TS) areas were investigated separately. Survival analyses were used to evaluate the markers correlation to PCa outcome. In univariate analyses, ERα in TS was associated with delayed time to clinical failure (CF) (p = 0.042) and PCa death (p = 0.019), while ERβ was associated with reduced time to biochemical failure (BF) (p = 0.002). Aromatase in TS and TE was associated with increased time to BF and CF respectively (p = 0.016, p = 0.046). Multivariate analyses supported these observations, indicating an independent prognostic impact of all markers. When stratifying the analysis according to different surgical centers the results were unchanged. In conclusion, significant prognostic roles of ERα, ERβ and aromatase were discovered in the in PCa specimens of our large multicenter cohort.en_US
dc.descriptionPublished version. Source at <a href=http://dx.doi.org/10.1038/srep33114> http://dx.doi.org/10.1038/srep33114 </a>en_US
dc.identifier.citationGrindstad, T. et al. Estrogen receptors α and β and aromatase as independent predictors for prostate cancer outcome. Sci. Rep. 6, 33114; doi: 10.1038/srep33114 (2016).en_US
dc.identifier.cristinIDFRIDAID 1386756
dc.identifier.doi10.1038/srep33114
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/10365
dc.language.isoengen_US
dc.publisherNature Publishing Groupen_US
dc.relation.journalScientific Reports
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk biokjemi: 726en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical biochemistry: 726en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.titleEstrogen receptors α and β and aromatase as independent predictors for prostate cancer outcomeen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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