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dc.contributor.authorBalteskard Rinde, Ludvig
dc.contributor.authorLind, Caroline
dc.contributor.authorSmåbrekke, Birgit
dc.contributor.authorNjølstad, Inger
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorLøchen, Maja-Lisa
dc.contributor.authorMathiesen Hald, Erin
dc.contributor.authorVik, Anders
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorHansen, John-Bjarne
dc.contributor.authorRinde, Ludvig Balteskard
dc.date.accessioned2017-03-03T15:19:38Z
dc.date.available2017-03-03T15:19:38Z
dc.date.issued2016-05-10
dc.description.abstractBackground: Recent studies have demonstrated an association between venous thromboembolism (VTE) and arterial thrombotic diseases. <p> Objectives: We aimed to study the association between incident myocardial infarction (MI) and VTE in a prospective population-based cohort. <p> Methods: Study participants (n=29 506) were recruited from three surveys of the Tromsø Study (conducted in 1994-95, 2001-02 and 2007-08) and followed through 2010. All incident events of MI and VTE during follow-up were recorded. Cox-regression models with age as time scale and MI as a time-dependent variable were used to calculate hazard ratios (HR) of VTE adjusted for sex, BMI, blood pressure, diabetes mellitus, HDL-cholesterol, smoking, physical activity and education level. <p> Results: During a median follow-up of 15.7 years, 1 853 participants experienced a MI and 699 experienced a VTE. MI was associated with a 51% increased risk of VTE (HR 1.51; 95% CI 1.08-2.10) and a 72% increased risk of pulmonary embolism (PE) (HR 1.72; 95% CI 1.07-2.75), but not significantly associated with risk of deep vein thrombosis (DVT) (HR 1.36, 95% CI, 0.86-2.15). The highest risk estimates for PE were observed during the first sixth months after the MI (HR 8.49; 95% CI 4.00-18.77). MI explained 6.2% of the PEs in the population (population attributable risk) and 78.5% of the PE risk in MI-patients (attributable risk). <p> Conclusions: Our findings indicate that MI is associated with a transient increased risk of VTE independent of traditional atherosclerotic risk factors. The risk estimates were particularly high for PE.en_US
dc.descriptionManuscript. Published version available at <a href=http://dx.doi.org/10.1111/jth.13329> http://dx.doi.org/10.1111/jth.13329 </a>en_US
dc.identifier.citationRinde LB, Lind C, Småbrekke B, Njølstad I, Mathiesen EB, Wilsgaard T, Løchen M-L, Hald EM, Vik A, Brækkan SK, Hansen J-B. Impact of incident myocardial infarction on the risk of venous thromboembolism: the Tromsø Study. J Thromb Haemost 2016; 14: 1183–91.en_US
dc.identifier.cristinIDFRIDAID 1370911
dc.identifier.doi10.1111/jth.13329
dc.identifier.issn1538-7933
dc.identifier.issn1538-7836
dc.identifier.urihttps://hdl.handle.net/10037/10428
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalJournal of Thrombosis and Haemostasis
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk biokjemi: 726en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical biochemistry: 726en_US
dc.title.alternativeMyocardial infarction and venous thromboembolismen_US
dc.titleImpact of incident myocardial infarction on the risk of venous thromboembolism: the Tromsø Studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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